One Creatine Dose Kept Sleep-Deprived Brains 12% Sharper 

A randomized, double-blind crossover trial kept 29 healthy adults awake for 21 hours straight ... half the time on a single moderate dose of creatine (~14g), half the time on placebo ... and found the creatine group held on to up to 12% more cognitive performance across logic, reaction time, and language processing. Host Dave Asprey breaks down why sleep deprivation is just another form of brain energy stress, how creatine's phosphate-buffering mechanism stabilizes ATP in the prefrontal cortex under pressure, and why this changes how he thinks about red-eye flights and all-nighters. Vegetarians and women showed the largest effects ... your baseline diet sets your ceiling. 

Sources: 

https://pubmed.ncbi.nlm.nih.gov/42075005/ https://www.nutraingredients.com/Article/2026/04/21/single-dose-creatine-may-support-cognition-in-sleep-deprivation-study/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10902318/ https://medicalxpress.com/news/2024-04-creatine-cognitive-deprivation.html 

 

 

Your Gum Is Dosing You With Thousands of Microplastics 

A pilot study tested 10 commercial gums ... five synthetic, five marketed as natural or plastic-free ... and found every single one shed hundreds to roughly 3,000 microplastic fragments per stick into saliva, with no meaningful difference between synthetic and "natural" varieties. Host Dave Asprey connects this to total toxic load management, explains why "natural" label claims mean nothing without polymer-free verification, and makes the case that even innocent daily habits contribute to the cumulative plastic burden most people aren't tracking. The takeaway isn't panic ... it's precision. 

Sources: 

https://www.acs.org/pressroom/presspacs/2025/march/chewing-gum-can-shed-microplastics-into-saliva-pilot-study-finds.html https://www.sciencedirect.com/science/article/pii/S2666911025000243 https://samueli.ucla.edu/bursting-your-bubble-chewing-gum-releases-microplastics-into-your-saliva-ucla-research-shows/ https://www.food-safety.com/articles/10285-study-shows-chewing-gum-releases-thousands-of-microplastics-whether-gum-is-synthetic-or-natural 

 

 

Irregular Bedtimes in Your 40s May Double Heart Attack Risk 

Finnish researchers followed 3,231 people from age 46 using objective accelerometer data and tracked cardiovascular outcomes for a decade ... finding that people with highly irregular bedtimes, especially combined with short sleep, had roughly double the risk of major cardiovascular events compared to those with consistent sleep timing. Host Dave Asprey explains why your vascular biology runs on a precise circadian schedule, why ambitious, otherwise-healthy people are most at risk of ignoring this lever, and why a 90-minute bedtime window ... protected even on weekends ... may be one of the cheapest cardiovascular interventions available. It'snot just how much you sleep. It's when. 

Sources: 

https://www.sciencedaily.com/releases/2026/05/260504154026.htm https://hsph.harvard.edu/topic/aging/ 

 

Scientists Decode the Plant Molecule That Kills Cancer Cells in the Lab 

UBC researchers published a chromosome-level genome map of Mitragyna parvifolia ... a kratom relative ... and used it to decode the full biosynthetic pathway for mitraphylline, a rare alkaloid that has shown real anti-tumor activity in cell and animal models but has never been producible at clinical scale. Host Dave Asprey explains why this is the same early chapter that vincristine and paclitaxel were in before becoming mainstream chemotherapy, draws a hard line between this pipeline story and influencer narratives about kratom as a cancer treatment, and breaks down what it actually means when researchers crack a plant's genetic recipe for a bioactive compound. Nature has been solving cancer for millions of years... we're finally learning to read it. 

Sources: 

https://academic.oup.com/plcell/article/37/9/koaf207/8237526 https://www.sciencedaily.com/releases/2026/05/260512213836.htm https://news.ok.ubc.ca/2025/10/14/researchers-reveal-how-plants-make-anti-tumour-drugs/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12217235/ 

 

Scientists Built an On/Off Switch for Sperm Production ? No Hormones 

Cornell researchers used a small-molecule inhibitor called JQ1 to pharmacologically shut down sperm production in male mice for the duration of treatment, then stopped the drug and watched full fertility restore... with healthy offspring and no detectable genomic damage. Host Dave Asprey breaks down the BRDT mechanism that makes this work without touching testosterone or hormones, explains why this is a proof-of-concept rather than a near-market drug, and outlines the questions that need answering before this moves to humans: long-term testicular health, epigenetic marks in recovered sperm, and mood and testosterone interaction over time. The era of precision male reproductive biology is just beginning. 

Sources: 

https://pubmed.ncbi.nlm.nih.gov/41945432/ https://www.sciencedaily.com/releases/2026/04/260407193844.htm https://www.news-medical.net/news/20260407/Study-advances-safe-reversible-male-contraceptive-without-hormones.aspx https://www.independent.co.uk/news/science/breakthrough-male-birth-control-sperm-b2972841.html 

 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on cognitive performance, toxic load management, circadian biology, plant-derived drug discovery, and the future of male reproductive medicine. Host Dave Asprey connects emerging clinical research, objective epidemiological data, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science. 

 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

 

Keywords: creatine sleep deprivation cognition, brain energy ATP creatine, microplastics chewing gum, natural gum microplastics, toxic load biohacking, irregular bedtime heart attack risk, circadian rhythm cardiovascular, sleep timing heart health, mitraphylline cancer compound, kratom plant alkaloid drug discovery, oncolytic plant molecule, male birth control non-hormonal, sperm production reversible, BRDT JQ1 contraception, biohacking news 2026, longevity research, performance optimization, healthspanextension 

 

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Resources:   

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps: 

00:00 ? Intro 

00:36 ? Fluoride Correction 

01:14 ? Story 1: Creatine & Sleep Deprivation 

03:21 ? Story 2: Microplastics in Gum 

04:53 ? Story 3: Irregular Bedtimes & Heart Risk 

06:31 ? Story 4: Kratom Plant & Cancer Research 

08:18 ? Story 5: Male Contraception On/Off Switch 

10:02 ? Wrap-Up 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

If you're over 50 and still doing cardio to stay healthy, you're wasting your time and may actually be making things worse. This episode breaks down the exact movements, supplements, and anti-aging strategies that build real strength, protect your bones, and extend your longevity without spending hours in the gym. 

 

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

 

Host Dave Asprey sits down with Will Harlow, a master's-level physiotherapist and founder of HT Physio, whose YouTube channel has amassed over 1.5 million subscribers by teaching people over 50 how to stay mobile, active, and independent without painkillers or surgery. Will graduated with a first-class degree from Brunel University, trained in both the NHS and professional sport, and has spent his career proving that what most doctors call "just aging" is actually optional. 

 

Together, Dave and Will dismantle the myths keeping older adults weak, injured, and overtrained. They get into why resistance training beats cardio for human performance and metabolism at every age, how anabolic resistance changes your protein needs after 50, which three compound movements deliver the biggest functional gains, and why your grip strength may be the most underrated biomarker you're ignoring. Dave also shares how he used biohacking, targeted supplements, and functional medicine principles to grow bones so dense his surgeon couldn't cut through them. They also dig into vestibular training, hydration, magnesium, Vitamin DAKE, and how tools like AI are now helping people identify movement problems before they become joint replacements. 

 

This is essential listening for anyone serious about longevity, anti-aging, biohacking, sleep optimization, supplements, smarter not harder training, human performance, and building a body that performs decades past its expiration date. 

 

You'll Learn: 

Why chronic cardio decreases bone density and muscle mass in people over 50 The 3-2-1 resistance training method that delivers 80% of results in 40 minutes a week How anabolic resistance changes protein requirements as you age and what to do about it The three compound movements every person over 50 should master first Why grip strength predicts overall health and how to train it How vestibular disorders silently destroy balance and confidence, and how to reverse them The supplement stack (Vitamin DAKE, magnesium glycinate, digestive enzymes) that supports bone, muscle, and metabolism Why 7,000 steps beats 10,000, and where that number actually came from How Dave used biohacking and functional medicine to grow bones that broke a surgeon's saw Why AI tools can now spot gait problems that lead to hip replacements years later 

Thank you to our sponsors!      

- Active Skin Repair | Get 25% off your order until May 21, after that, it drops back to 20%, visit ActiveSkinRepair.com and use code DAVE. You can also find Active Skin Repair on Amazon and at your local CVS  

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- Neuronic | Go to www.neuronic.online Code DAVE for $100 off 

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- fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. 

 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

 

Keywords: Will Harlow, HT Physio, Independence for Life, physiotherapy, physical therapy, over 50 fitness, resistance training, strength training, muscle mass, bone density, osteoporosis, goblet squat, Romanian deadlift, farmer's carry, compound movements, progressive overload, 3-2-1 method, exercise snacks, balance training, vestibular health, vestibular disorders, fall prevention, hip fracture, anabolic resistance, protein intake, muscle protein synthesis, grip strength, zone 2 cardio, overtraining, sarcopenia, frailty, mobility, functional movement, gait analysis, fascia, inflammaging, NLRP3, EGCG, green tea extract, luteolin, shockwave therapy, digestive enzymes, betaine HCL, stomach acid, magnesium glycinate, Vitamin K2, Vitamin DAKE, zinc, calcium, electrolytes, cortisol, testosterone, anti-aging, longevity, biohacking, supplements, human performance, metabolism, AI, Dave Asprey, 7000 steps, 10000 steps, pedometer, body weight training, resistance bands, home workout, senior fitness, healthy aging, biological age, heart rate variability, VO2 max, morning stiffness, hip pain, knee pain, back pain, fascia hydration, infant reflexes, vestibular training, eye tracking, sit to stand, bone density surgery, dense bones, UK healthcare, NHS, healthcare system 

 

Resources:   

? Preorder Will?s Upcoming Book Independence for Life (5/26) at: https://www.penguinrandomhouse.com/books/804636/independence-for-life-by-will-harlow/ 

? Learn More About Will?s Work: https://willharlow.com/ 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps:  

00:00 ? Trailer 

00:36 ? Intro 

02:59 ? Why Resistance Training Matters 

03:38 ? US vs. UK Health Culture 

06:15 ? Getting Started with Resistance Training 

07:12 ? Top 3 Movements Over 50 

10:30 ? Hip Mobility & Inflammation 

12:19 ? Hydration, Joints & Electrolytes 

14:11 ? Balance, Falls & Exercise Snacks 

15:21 ? Biological Age & Longevity 

16:41 ? Biohacking vs. Optimization 

20:08 ? Overtraining & the 3-2-1 Method 

29:42 ? Protein & Anabolic Resistance 

33:57 ? Energy, Fat & Cortisol 

37:49 ? Vestibular Health & Balance 

50:07 ? Gait & Movement Rehab 

56:56 ? Steps, VO2 Max & Wearables 

57:25 ? Book Promo 

01:02:14 ? 7,000 Steps 

01:04:22 ? Wrap-Up 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The person you love is either raising your hormones or destroying them, and most people have no idea which one is happening to them. John Gray, the author of one of the most beloved relationship books of all time, returns to reveal how your relational environment directly shapes your biology, and what you can do right now to hack it. 

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

John Gray wrote Men Are from Mars, Women Are from Venus, the number one bestselling book of the entire decade and one of USA Today's top 10 most influential books of the last quarter century. His books have been translated into 45 languages across more than 100 countries. But what most people miss is that Gray is also a pioneer in the intersection of hormonal health, brain optimization, and human performance, a biohacker before the word existed. His newest book, Men Are from Mars for Women Only: Be Happy With or Without a Man, is the first in a six-part series packed with cutting-edge insights on relationships, biology, and longevity. 

Host Dave Asprey and John Gray go deep on the hormonal mechanics of desire, attraction, and emotional regulation, covering why societal testosterone collapse is driving relationship breakdown, how estrogen and testosterone function as a polarity system in both men and women, and why the relational environment you create every day is either building or destroying your biological potential. They also cover lithium orotate as a brain optimization supplement, the anti-aging power of semen retention, pre-digested protein as a nootropics-adjacent tool for brain healing, and how fasting and discipline directly boost testosterone. Gray even shares how he reversed early-stage Parkinson's using biohacking techniques and now maintains a testosterone level of 600 at age 74, with zero pharmaceutical support. 

This is essential listening for anyone serious about biohacking, longevity, anti-aging, supplements, human performance, brain optimization, functional medicine, metabolism, and hacking the biology of love and attraction. 

You'll Learn: 

Why testosterone collapse is the hidden driver behind modern relationship failure How your partner's emotional state directly affects your hormones in real time The prolactin trap that kills sexual desire in long-term relationships and how to escape it Why lithium orotate is one of the most underrated supplements for dopamine and serotonin balance How mirror neurons open and close based on stress, and what that means for emotional connection The five-finger ask technique that raises estrogen and testosterone simultaneously How pre-digesting protein with enzymes achieves 93 percent assimilation and supports brain repair Why fasting, discipline, and semen retention are among the most powerful testosterone-building tools available 

 

Thank you to our sponsors!      

- Active Skin Repair | Get 25% off your order until May 21, after that, it drops back to 20%, visit ActiveSkinRepair.com and use code DAVE. You can also find Active Skin Repair on Amazon and at your local CVS  

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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: John Gray, Men Are from Mars Women Are from Venus, testosterone, estrogen, hormonal health, hormone optimization, prolactin, oxytocin, dopamine, serotonin, lithium orotate, mirror neurons, longevity, anti-aging, biohacking, supplements, fasting, semen retention, NoFap, multi-orgasmic men, sexual health, libido, foreplay, relationship advice, men and women, emotional regulation, stress hormones, cortisol, adrenaline, epigenetics, Parkinson's disease, protein assimilation, digestive enzymes, pre-digested protein, whey protein, casein protein, Mars Venus app, five finger ask, Venus talk, emotional processing, trauma, post traumatic stress, testosterone collapse, relationship breakdown, attraction, desire, masculine feminine polarity, Dave Asprey, 40 Years of Zen, hormones and behavior, relational biology, conscious relationships, mirror neurons and sex, luteinizing hormone, monk celibacy, meditation 

Resources:   

? Grab All Of John?s Books And Content At: https://www.marsvenus.com/ 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps:  

00:00 ? Trailer 

00:45 ? Intro 

02:23 ? Testosterone & Relationship Collapse 

02:41 ? Hormones & Stress 

08:37 ? Attraction & Sexual Polarity 

10:36 ? Communication & Conflict 

20:21 ? Emotions & Trauma 

21:27 ? Mirror Neurons 

31:03 ? Masculine vs. Feminine Energy 

45:05 ? Lithium Orotate 

49:52 ? Protein & Longevity 

54:02 ? Semen Retention 

59:46 ? Prolactin & Long-Term Desire 

1:09:12 ? Sex & Mirror Neurons 

1:12:45 ? The Five Finger Ask 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

If you are constantly bloated, fatigued, and feeling heavy, your gut bacteria have taken over. The standard advice is to just stop eating and do a multi-day water fast. But if your gut is already inflamed, a strict zero-calorie fast will actually spike your cortisol, trigger adrenaline crashes, and blow open the tight junctions in your intestinal wall.

In this video, I break down the Italian fasting hack engineered by longevity researcher Valter Longo: The Fasting Mimicking Diet (FMD).

I explain exactly how to structure this 5-day protocol to trick your body into autophagy (cellular cleanup) while still eating 800 to 1100 calories of specific fats and complex carbs. You will learn how constant "grazing" paralyzes your Migrating Motor Complex, why hidden proteins in vegetables are secretly kicking you out of fasting mode, and the exact step-by-step protocol to re-feed your microbiome on Day 6 without causing a massive inflammatory storm.

Thank you to our sponsors!

-GOT MOLD? | Go to http://gotmold.com/shopand use DAVE10 to save 10% and see what?s in your air

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-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Timestamps:

00:00 ? Intro

00:40 ? Gut Ecosystem

01:00 ? Constant Snacking

02:57 ? Gut-Brain Connection

03:40 ? Why Standard Fasting Can Backfire

07:22 ? The Fasting Sweet Spot

09:21 ? Introducing the FMD

10:43 ? Pre-Reset: Prep Days

13:24 ? The 5-Day FMD Protocol

16:47 ? Meal Timing & Circadian Rhythm

17:46 ? Sleep, Stress & Recovery

18:22 ? How Often to Do FMD

19:23 ? Wrapup

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey?s BEYOND Conference: https://beyondconference.com/

Dave Asprey?s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

*Testosterone Directly Suppresses Brain Tumor Growth in Males by 38% 

Cleveland Clinic research funded by NIH shows testosterone binds androgen receptors in glioblastoma stem cells ? the root of tumor recurrence ? and cuts growth by 38% when levels are restored. Dave breaks down why the mainstream framing of testosterone and cancer risk has it backwards, what androgen deprivation therapy may be doing to every other cancer pathway simultaneously, and why your hormone panel is now a cancer conversation, not just a performance one. 

Sources:  

-https://www.nih.gov/news-events/news-releases/nih-funded-study-suggests-testosterone-suppresses-brain-tumor-growth-males  

-https://bioengineer.org/nih-funded-research-indicates-testosterone-may-inhibit-brain-tumor-growth-in-males/ 

 

*CDC Halts Rabies Testing Nationwide  

A CDC staffing crisis has pushed rabies, mpox, and Epstein-Barr testing to overwhelmed state labs, creating one-to-two week diagnostic delays in a disease where post-exposure prophylaxis must begin within ten days of a bite ? and where fatality is virtually 100% once symptoms appear. Dave explains exactly what to do if you or a pet is exposed, why outdoor biohackers are the most exposed population, and what pre-travel prevention looks like for anyone heading to endemic regions. 

Sources:  

-https://www.nbcnews.com/health/health-news/cdc-pauses-testing-rabies-monkeypox-epstein-barr-viruses-rcna266377  

-https://www.cidrap.umn.edu/rabies/state-public-health-labs-step-cdc-pauses-testing-various-pathogens-including-rabies-mpox 

 

*Mifepristone Mail Ban  

The Supreme Court issued a one-week stay blocking a 5th Circuit ruling that would have ended telehealth and mail access to mifepristone, used in over 63% of U.S. abortions. Dave sets aside the moral debate to focus on what this legal precedent means for FDA-approved compounded peptides, bioidentical hormones, and telehealth access to any treatment without full pharmaceutical backing ? and why this case is one every biohacker should be tracking closely. 

Sources:  

-https://www.usnews.com/news/health-news/articles/2026-05-05/supreme-court-issues-stay-keeping-abortion-pill-mifepristone-available-by-mail-for-now  

-https://www.npr.org/2026/05/04/nx-s1-5810510/supreme-court-mifepristone-appeals-telehealth 

*Cow Flu and Dog Coronavirus  

University of Florida scientists are watching Influenza D ? endemic in U.S. cattle herds ? and canine coronavirus HuPn-2018, which already jumped to humans in China, as the two zoonotic threats most likely to achieve widespread human transmission. Dave covers why the conditions producing these jumps aren't going away, what the Influenza D finding means for the raw milk conversation right now, and the mucosal immunity stack that puts you in the strongest position regardless of which virus makes the leap next. 

Sources:  

-https://ufhealth.org/news/2026/scientists-say-these-two-viruses-may-become-the-next-public-health-threats 

-https://www.gavi.org/vaccineswork/six-major-health-threats-could-shape-2026-heres-what-experts-are-watching 

*Hantavirus Kills 3 on Cruise Ship  

Eight confirmed or suspected cases of Andes hantavirus aboard the MV Hondius off the Canary Islands have killed three and left two critical, with passengers from 23 countries already dispersed through global airports. Dave cuts through the pandemic panic to explain why American and South American hantavirus strains are categorically more lethal than European ones, why Andes is the only strain on earth that spreads human to human via respiratory droplets, and what early symptom recognition could mean for your survival window if exposure reaches your community. 

Sources: 

-https://www.cnn.com/2026/05/07/world/hantavirus-ship-tenerife-outbreak-intl 

-https://www.nbcnews.com/health/health-news/hantavirus-andes-virus-what-is-cruise-ship-outbreak-deadly-strain-rcna343901 

 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on hormonal optimization, infectious disease risk, immune resilience, and the legal infrastructure shaping medical autonomy. Host Dave Asprey connects emerging NIH research, Supreme Court developments, and live outbreak data into actionable frameworks for protecting your biology when institutions can't do it for you. 

 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

 

Keywords: testosterone brain cancer, testosterone glioblastoma, low testosterone tumor risk, androgen deprivation therapy cancer, CDC rabies testing paused, rabies post-exposure prophylaxis, rabies exposure protocol, mifepristone telehealth ban, SCOTUS mifepristone stay, telehealth medical autonomy, compounded hormones legal risk, influenza D cattle virus, canine coronavirus HuPn-2018, zoonotic virus 2026, raw milk bird flu risk, mucosal immunity biohacking, hantavirus cruise ship, Andes hantavirus outbreak, MV Hondius hantavirus, hantavirus human to human transmission, hantavirus vs coronavirus, biohacking news 2026, Dave Asprey weekly roundup, longevity research 2026 

 

Thank you to our sponsors!  

- Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap 

- Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. 

- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE 

 

Resources:   

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps: 

00:00 ? Intro 

00:35 ? 1. Testosterone & Brain Cancer 

02:30 ? 2. CDC Pauses Rabies Testing 

04:09 ? 3. Mifepristone & Telehealth Access 

05:42 ? 4. Influenza D & Canine Coronavirus 

07:15 ? 5. Hantavirus Cruise Ship Outbreak 

09:36 ? Takeaways 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if an invisible field could protect your brain from EMF damage, improve your HRV, accelerate recovery, and optimize your biology without pills, devices, or a single lifestyle change? Host Dave Asprey sits down with Philippe Samor von Holtzendorff-Fehling, founder of Leela Quantum Tech and Quantum Upgrade, to explore one of the most controversial and compelling frontiers in biohacking today: quantum energy fields delivered remotely, in real time, to your body, your pets, your home, and even your business. 

 

-Try Quantum Upgrade Free for 15 days, no credit card required: quantumupgrade.io/dave 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  

Philippe Samor von Holtzendorff-Fehling is a coach, conscious entrepreneur, and energy healer who built a parallel path alongside a high-level international business career, working through his own blockages to fully connect with his true self. He served as Vice President at both T-Mobile International and T-Mobile US, and is now the founder and CEO of Leela Quantum Tech and Quantum Upgrade. He is also a kundalini yoga teacher, a passionate bio and bio-energy hacker, a father of two, a dog lover, and the number one ranked tennis player in the US in the Men 50+ category. His work sits at the intersection of functional medicine, quantum biology, and human performance, and the science behind his technology is harder to dismiss than most people expect. 

Dave and Philippe go deep on how chronic EMF exposure from 5G towers, Starlink satellites, electric vehicles, and everyday Wi-Fi actively disrupts your brain waves, blood cells, heart rate variability, and mitochondria function. They also break down how Quantum Upgrade works as a remote, customizable field that can harmonize these frequencies in real time, and why it may be one of the most underrated tools for sleep optimization, brain optimization, recovery, anti-aging, and longevity. 

This episode also covers the groundbreaking work Philippe is doing with autistic children, including a clinical study showing measurable reductions in autism spectrum scores, and a remarkable collaboration with Susie Miller of the Telepathy Tapes. 

This is essential listening for anyone serious about biohacking, human performance, anti-aging, longevity, brain optimization, sleep optimization, functional medicine, mitochondria health, and hacking every system in your body with smarter not harder solutions. 

You'll Learn: 

Why EMF from 5G, Starlink, and electric vehicles is more biologically dangerous than most people realize How a 256-channel EEG captured real-time brain changes triggered by Quantum Upgrade What "quantum coherence" actually means for your biology and why it matters for human performance and longevity How remote quantum fields affect HRV, blood clarity, ATP production, and mitochondria function Why autistic children showed measurable spectrum score reductions in a clinical trial using this technology How to customize your own quantum field for sleep optimization, recovery, energy, and brain optimization What Dave uses Quantum Upgrade for at his 40 Years of Zen facility in Austin 

 

Thank you to our sponsors!      

- Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave 

- Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today 

- Timeline | Go to timeline.com/dave and you?ll get an additional 20% off your first month 

- Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Philippe Samor von Holtzendorff-Fehling, Quantum Upgrade, Leela Quantum Tech, quantum energy, EMF protection, electromagnetic fields, 5G health effects, Starlink radiation, biohacking, human performance, longevity, anti-aging, brain optimization, sleep optimization, mitochondria, functional medicine, HRV, heart rate variability, dark field microscopy, EEG, ATP production, quantum coherence, biofield, energy healing, autism spectrum, telepathy tapes, Susie Miller, kundalini yoga, electric vehicle EMF, Wi-Fi health effects, smarter not harder, Dave Asprey, 40 Years of Zen, wound healing, placebo controlled trials, quantum biology, coherent field, EMF harmonization, remote quantum field, energy frequency, conscious entrepreneurship 

Resources:   

? Try Quantum Upgrade Free for 15 days, no credit card required: quantumupgrade.io/dave 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps:  

00:00 ? Trailer 

01:15 ? What Science Can't Explain 

04:05 ? What Is Quantum Upgrade? 

06:04 ? The Research 

07:47 ? Origin Story 

12:20 ? EEG Testing & Brain Effects 

12:53 ? EMFs, Electric Cars & 5G 

17:57 ? Measuring Results 

21:25 ? Autism Study & Telepathy Tapes 

26:16 ? Frequencies & Settings 

29:09 ? Starlink & Global EMF 

30:54 ? Skeptics & Proof 

33:08 ? Kids & Pets 

37:10 ? Wrap-Up & Free Trial 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your biological age can drop by over three years in just eight weeks, and the tools to do it are already in your kitchen. This episode breaks down the cutting-edge science of methylation, polyphenols, Yamanaka mimetics, and epigenetic reprogramming that is rewriting what we know about anti-aging, longevity, and human performance. 

 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Kara Fitzgerald, ND, IFMCP, a leading voice in functional medicine and epigenetic aging research. Her award-winning clinical studies published in Aging (2021, 2023, and 2025) proved that targeted diet and lifestyle interventions can measurably reverse biological age on validated epigenetic clocks. She is the author of Younger You, an IFM faculty member and Certified Practitioner, and one of the most rigorously credentialed researchers working at the intersection of functional medicine, nutrition, and longevity science today. 

Together, they go deep on Yamanaka factors, the Nobel Prize-winning discovery that can wind back a 90-year-old cell to its 20s, and the emerging class of compounds called Yamanaka mimetics, polyphenol-based supplements that may replicate some of those same cellular rejuvenation effects without the risks. They cover why polyphenols do the heavy lifting in biological age reversal, how AI is accelerating longevity research, and why the dark matter of nutrition may matter more than macros, carnivore protocols, or ketosis for long-term health. They also get into oxalates, mitochondria, fibroids, ovarian rejuvenation, and why the original Horvath clock may be more relevant than scientists thought. 

This is essential listening for anyone serious about biohacking, longevity, supplements, functional medicine, anti-aging, brain optimization, human performance, and using smarter not harder strategies to take control of your biology. 

You'll Learn: 

How diet, supplements, and meditation reversed biological age by over three years in eight weeks in a randomized controlled trial What Yamanaka factors are and why scientists are calling partial cellular reprogramming the future of anti-aging Which polyphenols do the heaviest lifting for epigenetic rejuvenation, including EGCG, urolithin A, rosemary, marjoram, and yarrow Why the Horvath epigenetic clock may actually be touching on programmatic aging rather than just exposomic wear and tear How AI is unlocking patterns in longevity data that no human researcher could find alone The problem with high-oxalate superfoods and how to get polyphenol benefits without the inflammatory downside Why ovarian rejuvenation may be the highest-leverage Yamanaka application for women's longevity and brain health How compounds like AKG, sodium butyrate, and forskolin may act as Yamanaka mimetics already available today What the PRC2 polycomb clock reveals about programmatic aging and why it matters more than second-generation clocks Why perimenopause does not have to be painful, and how functional medicine addresses it at the root 

 

Thank you to our sponsors!      

- Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. 

- Viome | Check it out at viome.com and use code 10DAVE for 10% off. It?s time to stop guessing and start knowing your body. 

- STEMREGEN | Go to stemregen.co/dave30 Use code DAVE30 for 30% OFF your next order. 

- Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Kara Fitzgerald, biological age reversal, epigenetics, DNA methylation, Yamanaka factors, polyphenols, EGCG, urolithin A, anti-aging, longevity, biohacking, functional medicine, supplements, mitochondria, epigenetic clock, cellular reprogramming, AKG, sodium butyrate, methylation, Steve Horvath, Vittoria Sebastiano, coleus, perimenopause, ovarian rejuvenation, pluripotent stem cells, PRC2, dark matter of nutrition, TRIM study, dihydroxyflavone, BDNF, Prenuvo, chemical cellular rejuvenation 

Resources:   

? Learn more about all of Dr. Fitzgerald?s work at: https://www.drkarafitzgerald.com/ 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps:  

0:00 ? Trailer 

1:28 ? Explaining Study 

3:45 ? What Is The Diet 

6:49 ? Age Reversal 

8:17 ? Polyphenols vs. Supplements 

9:27 ? Food vs. Supplement Dosing 

12:41 ? Oxalate & Polyphenol Trade-offs 

18:41 ? Yamanaka Factors Explained 

28:59 ? Chemical Cocktails 

32:15 ? PRC2 Clocks & Programmatic Aging 

40:28 ? Seasonal Eating 

43:40 ? Carnivore Diet: Short vs. Long Term 

45:31 ? Inuit Diet 

46:39 ? Flavones & Brain-Crossing Compounds 

48:50 ? Why Only Men in the Study? 

51:05 ? Women, Perimenopause & the Protocol 

53:20 ? Fibroids & Gaps in Women's Research 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

I spent fifteen years living with brain fog until I realized the problem wasn?t in my brain, but in a nervous system stuck in a survival mode that pulls energy away from focus and memory.

In this video, I explain why "trying harder" or popping supplements rarely works, and instead, I show you the 9,000-year-old ritual of heat and cold that pulls your body out of stress mode so clarity can actually return.

I break down the specific science of how I use infrared wavelengths and contrast therapy to retrain the brain to stay calm under pressure, moving beyond temporary fixes to target the root cause of mental fatigue.

Follow this protocol to finally complete your body's stress cycles, reset your biological default settings, and reclaim the lasting mental performance you?ve been missing.

00:00 ? Introduction

01:02 ? What Brain Fog Really Is

03:00 ? Why Trying Harder Doesn't Work

04:51 ? Supplements: Useful But Not Enough

06:14 ? Why Sauna Works

07:32 ? Infrared vs Traditional Sauna

08:02 ? Sunlighten Sauna Overview

09:28 ? Sauna Routine & Protocol

10:34 ? Why Home Access Matters

11:41 ? Post-Session Recovery

12:11 ? Contrast Therapy

13:11 ? How to Do Contrast Therapy

13:54 ? Closing & Takeaways

Thank you to our sponsors!

-TRU KAVA | Head to trukava.com and use code DAVE10 for 10% off.

-Neuronic | Go to www.neuronic.online Code DAVE for $100 off

-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey?s BEYOND Conference: https://beyondconference.com/

Dave Asprey?s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week's stories: 

*Mud Playgrounds Double Kids' Bacterial Diversity and Spike Immune Genes 30% 

Finland swapped rubber playground surfaces for natural soil and mud across eight kindergartens ? and after just one month, kids in dirt had twice the bacterial species diversity on their skin and a 30% increase in expression of ten immune-related genes. Dave breaks down why your immune system requires microbial exposure to calibrate properly, what the hygiene hypothesis actually means for adults, and the dead-simple weekly habit that primes your innate immunity the same way. Sources: 

https://creators.yahoo.com/lifestyle/story/finland-replaced-artificial-playground-surfaces-with-natural-elements-like-mud-and-soil--and-the-results-surprised-even-researchers-184318556.html https://www.sciencedaily.com/releases/2026/04/mud-playground-immunity.htm 

*Mixing Exercise Types Cuts All-Cause Mortality Up to 40% in 170,000-Person Study 

A 30-year BMJ Medicine cohort study found that people who rotate at least three different types of exercise weekly see 19 to 40% lower all-cause mortality ? and that benefit held independent of total training volume. Dave explains why variety is a distinct biological signal, not a motivation trick, and why grinding more of the same thing is leaving longevity gains on the table. Sources: 

https://bmjmedicine.bmj.com/content/early/2026/04/26/bmjmed-2025-001513 https://www.sciencedaily.com/releases/2026/04/260426012305.htm https://www.theguardian.com/society/2026/apr/26/exercise-diversity-mortality 

*Facial Aging Rate from Photos Predicts Cancer Survival Better Than Blood Biomarkers 

AI analysis of serial facial photos in 1,000+ cancer patients found that computed facial aging rate independently predicted five-year survival with a hazard ratio of 2.1 ? outperforming CRP and other standard blood markers. Dave covers what the AI is actually reading in those photos, why your face is a more accurate biological ledger than most labs your doctor orders, and the free monthly habit that turns this into an early warning system. Sources: 

https://medicalxpress.com/news/2026-04-photos-reveal-faster-biological-aging.html https://www.nature.com/articles/s43587-026-00123-4 

*Vibration Vest OsteoBoost Mimics Weight-Bearing Exercise to Rebuild Bone Density 

OsteoBoost raised $8M for a wearable vest delivering 30?50Hz vibrations to the spine and hips, triggering the same Wnt/?-catenin osteoblast pathway activated by mechanical loading ? with early trials showing 2?5% bone mineral density gains in six months. Dave makes the case forwhy bone loss is one of the most underrated aging crises in the biohacking community, and who should be watching this category closely. Sources: 

https://longevity.technology/news/osteoboost-raises-8m-to-scale-bone-wearable/ https://www.crunchbase.com/organization/osteoboost 

*10+ States Advance Raw Milk Bills as H5N1 Hits 100+ Dairy Herds 

Legislation expanding raw milk access is moving in Arizona, Iowa, New Hampshire, and elsewhere ? while the CDC flags H5N1 in over a hundred dairy herds with documented aerosol transmission concerns. Dave gives an honest read on where the freedom argument, the microbiome argument, and the current risk calculus actually stand in April 2026, and what more rigorous sourcing looks like right now. Sources: 

https://www.yahoo.com/news/articles/us-med--raw-milk-legislation-120124275.html https://www.cdc.gov/flu/avianflu/dairy.htm 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on immune priming, exercise science, biological age tracking, bone health, and real food risk assessment. Host Dave Asprey connects emerging clinical research, large-scale cohort data, and real-world protocols into actionable frameworks for extending healthspan and sharpening performance. 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

Keywords: mud playground immune system microbiome, soil bacteria skin diversity, hygiene hypothesis biohacking, exercise variety longevity, BMJ exercise mortality study, mixed training lifespan, facial aging rate cancer survival, biological age face AI, facial photo biomarker longevity, OsteoBoost vibration vest bone density, whole body vibration osteoporosis, bone mineral density wearable, raw milk H5N1 bird flu, raw milk legislation 2026, raw dairy safety biohacking, biohacking news, longevity research 2026, Dave Asprey weekly roundup  

Thank you to our sponsors!  

- KILLSwitch | If you?re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off 

- Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18. 

- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE 

Resources:   

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps: 

00:00 ? Intro 

00:20 ? Dirt & Immune Training 

02:22 ? Exercise Variety & Longevity 

04:16 ? Facial Aging as a Health Biomarker 

05:47 ? Bone Loss & Vibration Tech 

07:31 ? Raw Milk & H5N1 Risk 

09:20 ? The Wrapup 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your cells are starving for oxygen, and it's silently driving inflammation, fatigue, brain fog, and accelerated aging. This episode reveals how pairing Exercise with Oxygen Therapy (EWOT) and red light therapy supercharges your mitochondria, reverses pseudo-hypoxia, and unlocks a level of human performance most people never experience. 

 

-Save up to $500 (through 5/17) at One Thousand Roads: https://www.onethousandroads.com/Dave 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Brad Pitzele, founder of One Thousand Roads and one of the most credible voices in oxygen therapy and red light therapy. Brad didn't come to this work through a lab. He came to it through desperation. After battling autoimmune arthritis, melanoma, and Lyme disease, he rebuilt his health from the ground up starting in 2016 by targeting mitochondrial function when he could barely walk. Eighteen months later, he founded One Thousand Roads to bring these tools to everyone still searching for a way out. 

Together, Dave and Brad break down the unified theory behind oxygen therapy and red light therapy, two of the most powerful and underrated tools in biohacking. They go deep on pseudo-hypoxia, the condition where your blood oxygen looks fine but your tissues are starving, and explain why this hidden dysfunction sits at the root of chronic fatigue, inflammaging, fibromyalgia, long COVID, and poor sleep optimization. They also cover the endothelium, nitric oxide, arterial stiffness, pulse wave velocity, and why your morning biology might be the most honest readout of your metabolic health. 

This is essential listening for anyone serious about longevity, anti-aging, brain optimization, functional medicine, mitochondria, metabolism, and smarter not harder approaches to human performance. 

You'll Learn: 

What EWOT is and why elite athletes and biohackers use it to flood tissues with oxygen in 15 minutes How pseudo-hypoxia silently blocks energy production and drives chronic illness Why stacking red light therapy immediately after EWOT multiplies results for both How mitochondrial dysfunction connects to endothelial aging, microcirculation failure, and systemic inflammation The role of nitric oxide in arterial flexibility, vasodilation, and real anti-aging markers like pulse wave velocity Why your lungs are your biggest detox organ and how oxygen therapy supports that process How ketosis, fasting, and cellular energy interact with EWOT and red light for maximum benefit What LED lighting is doing to your mitochondria every single day and how to fix it How to build an affordable at-home EWOT setup for around $2,500 

Thank you to our sponsors!      

- Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off. 

- ENERGYbits | If you want a simpler, smarter way to support your body? this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. 

- Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today 

- Cowboy Colostrum | Get your gut right by going to cowboycolostrum.com/asprey for 25% off of your entire order. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Brad Pitzele, One Thousand Roads, EWOT, exercise with oxygen therapy, oxygen therapy, red light therapy, infrared light therapy, pseudo-hypoxia, mitochondria, mitochondrial dysfunction, biohacking, longevity, anti-aging, human performance, inflammation, inflammaging, microcirculation, endothelium, glycocalyx, nitric oxide, arterial stiffness, pulse wave velocity, capillary health, cellular energy, ATP production, aerobic respiration, anaerobic respiration, VO2 max, chronic fatigue, fibromyalgia, brain fog, autoimmune disease, Lyme disease, Bartonella, long COVID, mast cell activation, detoxification, lung health, sleep optimization, metabolism, functional medicine, ketosis, fasting, red light bulbs, LED lighting, light therapy, wavelengths, near infrared, oxygen concentrator 

Resources:   

? Save up to $500 (through 5/17) at One Thousand Roads: https://www.onethousandroads.com/Dave 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps: 

00:00 ? Trailer 

01:41 ? Welcome Brad 

03:01 ? What Is EWOT? 

05:27 ? EWOT vs. Hospital Oxygen 

06:51 ? Longevity & Inflammaging 

11:42 ? Pseudo-Hypoxia 

12:57 ? Red Light Therapy 

15:47 ? EWOT + Red Light Unified Theory 

18:00 ? Nutrition, Ketosis & VO2 Max 

19:56 ? Stacking EWOT & Red Light 

22:01 ? Equipment & Cost 

26:00 ? Junk Light & LED Problems 

30:51 ? Sunlight & Nitric Oxide 

32:36 ? Endothelium & Microcirculation 

38:49 ? Arterial Stiffness & Pulse Wave Velocity 

43:29 ? Lungs as a Detox Organ 

45:04 ? EWOT for Long COVID 

47:58 ? Wrap-Up 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

If you're a woman in your 30s, 40s, or 50s feeling like your body is betraying you, this episode reveals the hormonal, gut, and environmental triggers behind perimenopause that most doctors never address, and exactly what you can do about it. 

 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Cynthia Thurlow, a nurse practitioner, CEO and founder of the Everyday Wellness Project, and a globally recognized expert in intermittent fasting and women's hormonal health. Her TEDx talk on intermittent fasting has surpassed 10 million views, and she brings over 20 years of functional medicine clinical experience to one of the most underserved conversations in longevity and human performance. 

Together, they tear apart the outdated medical narrative around perimenopause and menopause, exposing how a lack of knowledge, not biology, is destroying relationships, careers, and quality of life for millions of women. Dave and Cynthia dig into the gut microbiome's role in every symptom women experience in midlife, the mold toxin that is 10,000 times more potent than human estrogen and directly linked to hormonal chaos, and why biohacking your hormones as early as 35 could be the most important longevity move a woman makes. They also cover why statins are wrecking women's metabolism, how trauma accelerates ovarian aging and mitochondrial decline, the surprising connection between histamine reactions and hot flashes, and why GLP-1 micro-dosing alongside hormone replacement therapy is a game-changer for body composition and anti-aging. 

This episode is essential for listening for anyone serious about biohacking, sleep optimization, functional medicine, longevity, brain optimization, supplements, metabolism, human performance, and smarter not harder approaches to women's health. 

You'll Learn: 

Why perimenopause actually begins around age 35 and what to do about it before symptoms hit How a mold-derived xenoestrogen found in conventional beef disrupts hormones at 10,000 times the potency of human estrogen The gut microbiome changes that drive hot flashes, brain fog, weight gain, and mood disorders in perimenopause Why oral micronized progesterone beats topical for sleep optimization and hormonal stability How testosterone drives executive function, motivation, and brain optimization in women The lab tests every woman in perimenopause should run, including fasting insulin, ApoB, ferritin, and a full thyroid panel Why adverse childhood events and unresolved trauma age the ovaries and tank mitochondria How mold toxicity and Lyme disease create a hormonal perfect storm that no amount of supplements will fix The real reason 70 percent of divorces are initiated by women, and what hormones have to do with it 

Thank you to our sponsors!      

- Neuronic | Go to www.neuronic.online Code DAVE for $100 off 

- Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave 

- Joymode | Go to tryjoymode.com/DAVE Or enter DAVE at checkout for 20% off. 

- Viome | Check it out at viome.com and use code 10DAVE for 10% off. It?s time to stop guessing and start knowing your body. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Cynthia Thurlow, The Menopause Gut, perimenopause, menopause, hormones, hormone replacement therapy, HRT, bioidentical hormones, progesterone, estrogen, testosterone, thyroid health, gut microbiome, women's health, functional medicine, biohacking, longevity, anti-aging, human performance, mitochondria, sleep optimization, metabolism, supplements, mold toxicity, zearalenone, xenoestrogen, hot flashes, brain fog, body composition, GLP-1, intermittent fasting, trauma, cortisol, adrenal health, leaky gut, histamine intolerance, mast cell activation, insulin resistance, fasting insulin, ApoB, ferritin, statins, ovarian aging, Dave Asprey, smarter not harder 

Resources:   

? Learn More From Cynthia And Get Her New Book The Menopause Gut at: https://www.cynthiathurlow.com/ 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 ? Intro 

04:35 ? Root Causes of Perimenopause 

07:50 ? When Perimenopause Starts 

09:47 ? Progesterone: When & How 

12:16 ? Testosterone for Women 

14:14 ? Thyroid & Energy 

18:41 ? FDA's HRT Policy Change 

20:15 ? Hormones & Divorce

21:53 ? GLP-1s & Body Composition 

27:17 ? Key Lab Tests 

31:13 ? AI & Budget Labs 

39:44 ? Gut Microbiome & Menopause 

42:57 ? Histamine, Mast Cells & Hot Flashes 

47:55 ? Toxic Mold & Xenoestrogens 

50:31 ? Dairy, Raw Milk & Leaky Gut 

59:27 ? Healing Trauma 

1:03:00 ? Book Recommendations 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

When you hit your 40s, you start catching colds more easily, wounds take longer to heal, and you feel rundown even after a full night's sleep. Your doctor will tell you "it's just aging." They're wrong.

It's actually your immune cells suffocating on toxic waste because their power plants?your mitochondria?are breaking down.

In this video, I explain the exact biological mechanism behind "immune aging" and why your body's natural cleanup system (mitophagy) stalls out in your 40s and 50s. More importantly, I'm sharing the breakthrough compound scientists discovered that actually reverses this. It's a molecule called Urolithin A, originally found in pomegranates.

I dive into the massive problem with trying to get this molecule from food (only 30% of people have the right gut bacteria to even make it), and the 15 years of human clinical trials behind Mitopure?the supplement that bypasses your gut completely. I even share why I spent $100,000 on an extreme T-cell procedure before I knew I could just take this to get a younger immune system in 28 days.

00:00 ? Immune Decline After 40

00:39 ? Why Immune Cells Weaken

01:17 ? The Role of Mitochondria

02:25 ? Mitophagy & Its Decline

05:45 ? The Ancient Fruit: Pomegranates

06:39 ? The Problem With Pomegranates

07:19 ? Urolithin A as a Supplement

08:33 ? Trial Results

09:58 ? About MitoPure

10:46 ? Call to Action

Thank you to our sponsors!

-GOT MOLD? | Go to http://gotmold.com/shopand use DAVE10 to save 10% and see what?s in your air.

-Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave

-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

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The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey?s BEYOND Conference: https://beyondconference.com/

Dave Asprey?s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Frog venom burns your skin, makes you purge, and might be the most powerful healing tool you have never tried. In this episode, Host Dave Asprey sits down with Kambo researcher and practitioner Caitlin Thompson to break down how intentional suffering through this ancient Amazonian medicine is producing dramatic results for people with autoimmune conditions, chronic illness, Lyme disease, addiction, and metabolic dysfunction. From the peptide science behind the purge to the biohacking case for voluntary pain, this conversation will change how you think about healing, resilience, and human performance. 

 

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Caitlin Thompson is an internationally recognized Kambo practitioner and educator who has guided over 2,700 clients through this medicine, with a focus on Lyme disease, autoimmune conditions, and chronic illness. Her path into this work was shaped by her own recovery from Lyme disease and Lupus. Trained in neurobiology and rooted in psychedelic science, immune health, and the human microbiome, Caitlin is currently pioneering some of the first prospective human studies on Kambo. She collaborates directly with indigenous Amazonian communities including the Matsés, Shuar, Quechua, and Matis, and has appeared on over 100 podcasts and conferences as a leading voice at the intersection of traditional medicine and modern science. 

Dave and Caitlin break down the full Kambo experience, from the transdermal burns and peptide families flooding your lymphatic system, to the purge, the frog face, and the window of clarity that follows. They explore why the suffering is not a side effect but the actual mechanism, how ordeal medicine builds the same neuroplasticity and dopamine receptor sensitivity that meditation, breathwork, and ice baths produce, and why this ancient practice is becoming one of the most talked about tools in functional medicine and longevity circles. 

They also dig into the sustainability crisis threatening frog populations in the Amazon, the almost nonexistent research landscape for Kambo, why journals refuse to publish positive findings, and how AI may unlock the ability to synthesize Kambo peptides and remove the dependency on frogs entirely. 

You'll Learn: 

Why intentional suffering through Kambo may be one of the most effective biohacking tools for immune reset and brain optimization How Kambo peptides interact with your mitochondria, vagal nerve, and immune system to drive deep healing Why the purge is not a side effect but a keystone mechanism of the medicine How ordeal medicine builds dopamine receptor sensitivity and neuroplasticity similar to fasting, cold exposure, and breathwork What the actual risks of Kambo are and how hyponatremia kills people who do it wrong Why Caitlin recovered from Lupus and Lyme disease using Kambo and what that means for autoimmune conditions How Kambo compares to ketamine, ayahuasca, and other altered states for trauma and performance Why journals refuse to publish Kambo research and what that reveals about the drug development pipeline How AI and synthetic biology may soon make frog harvesting unnecessary What the worst Kambo practitioners do wrong and how to find someone you can actually trust 

Thank you to our sponsors!   

-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

-The One Device | Use code DAVE for $10 off at theonedevice.com/dave

-MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order.  

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Caitlin Thompson, Kambo practitioner, frog venom healing, Kambo ceremony, Kambo peptides, phyllo medusa bicolor, transdermal burns, hyponatremia Kambo, Kambo autoimmune, Lyme disease Kambo, Lupus recovery, ordeal medicine, intentional suffering dopamine, Kambo research, Kambo safety, Kambo training, Amazon frog medicine, Kambo vs ayahuasca, biohacking, Dave Asprey, human performance, neuroplasticity 

Resources:   

? Visit Caitlins Website to Learn More: https://kamboinstitute.org/ 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 ? Trailer 

01:15 ? Introduction

05:33 ? Guest Introduction 

09:46 ? Caitlin's Origin Story 

12:46 ? Kambo & Healing 

16:29 ? Trauma, PTSD & Psychosomatics 

19:36 ? What Is Kambo? 

22:41 ? Journey Duration 

24:26 ? Pharmacology & Peptides 

28:55 ? Publishing Challenges & Bias 

30:45 ? How to Do It Wrong 

32:22 ? Legal Status 

35:14 ? Synthesizing Kambo 

39:34 ? Indigenous Origins & Folklore 

42:46 ? Safety & Risks 

48:56 ? Where to Find Caitlin 

51:25 ? Pain, Resilience & BICEP 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your brain is aging faster than it should, and most of the decline is self-inflicted. Neuroscientist Dr. Tommy Wood reveals the exact mechanisms driving cognitive decay, and the biohacking strategies backed by hard science that can stop it, reverse it, and future-proof your brain at any age. 

-Watch this episode on YouTube: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Tommy Wood, one of the most credentialed minds working at the intersection of brain optimization, human performance, and longevity. Dr. Wood holds a medical degree from the University of Oxford, a PhD in physiology and neuroscience from the University of Oslo, and serves as Associate Professor of Pediatrics and Neuroscience at the University of Washington School of Medicine. He has published over 100 scientific papers, consulted with Olympians and world champions across more than a dozen sports, and worked directly with Formula 1 drivers to sustain elite focus and reaction time at 200 miles per hour. His forthcoming book, The Stimulated Mind: Future-Proof Your Brain from Dementia and Stay Sharp at Any Age, is the culmination of decades of research and real-world application. 

Together, Dave and Dr. Wood dismantle the myth that cognitive decline is inevitable, exposing how societal expectations become self-fulfilling prophecies and how the tools of biohacking, including sleep optimization, neuroplasticity training, nootropics, supplements, and strategic exercise, can dramatically shift your brain's long-term trajectory. They dig into the 3S Model of brain health (Stimulus, Supply, Support), the Yerkes-Dodson arousal curve and what it means for focus and flow states, and the surprising truth about AI, boredom, and what actually happens to your brain when you let ChatGPT do your thinking for you. 

This episode is essential listening for anyone serious about anti-aging, brain optimization, functional medicine, metabolism, human performance, and getting smarter without working harder. 

You'll Learn: 

Why cognitive decline is largely a self-fulfilling prophecy driven by expectation, not biology How the 3S Model (Stimulus, Supply, Support) determines your brain's long-term health and resilience What Formula 1 drivers teach us about arousal, flow states, and peak cognitive performance Why high-intensity interval training produces dramatically greater neuroplasticity benefits than Zone 2 cardio alone How creatine, nicotine, nootropics, and other supplements actually affect the aging brain The real data on alcohol, dementia risk, and what "occasional drinking" actually means scientifically How to use AI tools like ChatGPT in a way that builds brain function instead of destroying it Why boredom is a neurological necessity and how chronic low-level stimulation is quietly eroding your cognition What mitochondria and lactate signaling have to do with BDNF and long-term memory How resistance training, coordinative movement, and blood flow restriction each deliver separate and distinct cognitive benefits 

Thank you to our sponsors!      

- KILLSwitch | If you?re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off 

- Neuronic | Go to www.neuronic.online Code DAVE for $100 off 

- Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off. 

- Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Tommy Wood, The Stimulated Mind, brain health, cognitive decline, dementia prevention, neuroplasticity, brain optimization, biohacking, Dave Asprey, human performance, longevity, 3S model, brain stimulation, headroom, cognitive reserve, BDNF, lactate, Zone 2, HIIT, resistance training, blood flow restriction, sleep optimization, nootropics, creatine, nicotine, acetylcholine, supplements, ADHD, arousal curve, flow state, Formula 1, anti-aging, mitochondria, metabolism, AI and the brain, ChatGPT, digital dementia, boredom, neurogenesis, hippocampus, white matter, IGF-1, osteocalcin, alcohol and dementia, TMS, TDCS, vagal nerve stimulation, near infrared light, functional medicine, cognitive stimulation, stereotype embodiment theory 

Resources:   

? Learn More About Tommy And His Work At His Website: https://www.drtommywood.com 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps: 

00:00 ? Trailer 

01:28 ? Guest Intro: Dr. Tommy Wood 

03:37 ? F1 Drivers & Arousal Optimization 

09:01 ? Brain Headroom & the 3S Model 

13:14 ? Brain Stimulation Tech (TMS, TDCS) 

17:50 ? Cognitive Decline & Aging 

20:55 ? Alcohol & Brain Health 

24:10 ? ADHD & Brain Chemistry 

26:53 ? Nicotine & Cognitive Enhancement 

33:25 ? Creatine for the Brain 

35:12 ? Zone 2 vs. High-Intensity Exercise 

39:19 ? Strength Training & Brain Benefits 

43:12 ? Boredom & Cognitive Resilience 

45:06 ? AI & Brain Health 

52:49 ? Future-Proofing Your Brain 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You are not eating because you are hungry. You are eating because you have been trained to, and the food industry designed it that way. This episode dismantles everything you thought you knew about hunger, weight loss, and metabolism, and gives you a science-backed framework to finally stop fighting your own biology. 

 

-Watch this episode on YouTube: https://www.youtube.com/@DaveAspreyBPR 

 

Host Dave Asprey sits down with Dr. Jason Fung, a New York Times bestselling author, practicing nephrologist, and one of the most trusted voices in functional medicine and metabolic health. Dr. Fung completed medical school at the University of Toronto and a fellowship in nephrology at Stanford University. He is the author of multiple critically acclaimed books including The Obesity Code, The Diabetes Code, and his newest release The Hunger Code, and is the co-founder of The Fasting Method, a program designed to help people lose weight and reverse type 2 diabetes through fasting and real food nutrition. His work has helped millions break free from calorie restriction dogma for good. 

Together, Dave and Dr. Fung expose the three types of hunger driving the obesity epidemic, why calorie restriction fails almost every time, and what ultra-processed foods actually do to your brain's reward system. They get into the real science of fasting, metabolism, hormonal signaling, GLP-1 drugs, food addiction, conditioned eating behavior, and how your physical environment is quietly sabotaging your results. If you are serious about biohacking your hunger, optimizing your body composition, and taking control of your biology without white-knuckling willpower, this episode delivers the tools you need. 

This is essential listening for anyone focused on biohacking, longevity, human performance, fasting, metabolism, anti-aging, sleep optimization, brain optimization, functional medicine, and eating smarter not harder. 

You'll Learn: 

Why calorie restriction fails and what actually controls how much you eat The three types of hunger: homeostatic, hedonic, and conditioned, and how each one drives overeating How ultra-processed foods hijack your dopamine system and destroy satiety signals Why wiring your jaw shut or cutting your stomach still does not produce long-term weight loss What GLP-1 drugs like Ozempic actually reveal about hunger, metabolism, and the body fat thermostat How conditioned hunger works like Pavlov's dogs and practical strategies to reverse it The role of your physical environment in controlling food noise and cravings Why food addiction is real, and which foods are engineered to keep you hooked How fasting resets hunger signals, improves metabolic flexibility, and supports ketosis The mindset shift that makes healthy eating feel effortless instead of like deprivation 

 

Thank you to our sponsors!      

- OneSkin | Get 15% off OneSkin with code DAVE at oneskin.co/DAVE. 

- iRestore | Reverse hair loss with www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE 

- Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide 

- fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Jason Fung, The Hunger Code, fasting, intermittent fasting, hunger, food addiction, ultra-processed foods, calorie restriction, weight loss, obesity, type 2 diabetes, metabolism, insulin, leptin, hedonic hunger, conditioned hunger, food noise, GLP-1, Ozempic, dopamine, satiety, body fat thermostat, food environment, behavioral psychology, real food 

Resources:   

? Check out all of Dr. Fung?s books and content at: https://www.doctorjasonfung.com/ 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps: 

0:00 ? Trailer 

1:01 ? Introduction 

2:29 ? The 3 Types of Hunger 

4:41 ? Conditioned Hunger 

6:51 ? Ultra-Processed Foods 

11:47 ? Dave's Personal Story 

14:06 ? The Calorie Debate 

16:32 ? Restricting Calories Doesn't Work 

18:38 ? The 3 Whys Framework 

20:21 ? Shame in Weight Loss 

25:05 ? GLP-1 Drugs 

27:53 ? Ranking the 3 Hungers 

33:43 ? Food Addiction 

38:31 ? Fake Fats & Fake Sweeteners 

45:03 ? 3 Golden Rules for Weight Loss 

47:42 ? Deprogramming Hunger 

50:36 ? Pavlok & Behavior Hacking 

59:26 ? Outro 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

I lost 100 pounds, dropped to 4.8% body fat, and my lab tests say I'm biologically in my 30s... at 50 years old. Here's everything I got wrong about weight loss for years, and what actually worked.

After 18 months of low-calorie dieting and 700+ hours in the gym with zero fat loss, I discovered the truth about saturated fat, intermittent fasting, and why putting butter in my coffee every morning changed everything. This is the foundation of the Bulletproof Diet... and it's helped people around the world lose over a million pounds.

In this video I break down 9 weight loss myths that are keeping you fat and tired:

Why saturated fat is NOT bad for you (and what the real science says)The truth about low-fat diets and why they wreck your hormonesWhy counting calories is the wrong tool for fat lossHow intermittent fasting and butter coffee keep you in fat-burning mode all dayThe anti-nutrients hiding in "healthy" vegetables, whole grains, and fruitWhy 20 minutes of exercise per week beats 6 days in the gym

Whether you're struggling with stubborn belly fat, constant cravings, brain fog, or low energy... this video is for you. I cover grass-fed butter benefits, MCT oil, biohacking for weight loss, leptin resistance, insulin sensitivity, autophagy, and the real reason the low-fat movement made America sicker.

0:00 ? Introduction

03:14 ? Myth #1: Saturated Fat Is Bad for You

05:03 ? Myth #2: Low-Fat Diets Are Healthy

07:01 ? Myth #3: Cutting Calories Is the Key to Fat Loss

08:53 ? Myth #4: Eating Small Meals Boosts Your Metabolism

10:24 ? Myth #5: All Vegetables Are Good for You

12:10 ? Myth #6: Whole Grains Are Healthy

13:26 ? Myth #7: Fruit Is Always Healthy

14:42 ? Myth #8: You Need to Eat Breakfast Right Away

15:56 ? Myth #9: Exercise Is the Best Way to Lose Weight

Thank you to our sponsors!

Neuronic | Go to www.neuronic.online Code DAVE for $100 offSuperstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/daveiRestore | Grow thicker, healthier hair back naturally. Use code DAVE at irestore.com/DAVE 

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey?s BEYOND Conference: https://beyondconference.com/

Dave Asprey?s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week's stories: 

***Virologist Self-Injects Oncolytic Virus Therapy, Achieves 4-Year Remission in Triple-Negative Breast Cancer*** 

A researcher facing terminal triple-negative breast cancer (28% 5-year survival rate) engineered her own measles and vesicular stomatitis viruses and self-administered seven doses directly into her tumor outside formal clinical infrastructure. Four years cancer-free. Dave breaks down the mechanistic basis for oncolytic virotherapy?why cancer cells can't mount antiviral defenses that healthy tissue can?and the regulatory tension between patient autonomy and FDA gatekeeping on experimental immunotherapies. This is either a triumph of DIY biohacking or a cautionary tale about biosafety; either way, oncolytic virotherapy is accelerating toward mainstream clinical use and forcing a reckoning about access to cutting-edge cancer immunology. 

Sources: 

-https://www.dana-farber.org/newsroom/news-releases/2026/virus-based-therapy-boosts-anti-cancer-immune-responses-to-brain-cancer 

-https://www.eurekalert.org/news-releases/1116087 

-https://acgtfoundation.org/news/oncolytic-virus-therapy-for-cancer/ 

 

***Spermidine is the Missing Link Between Fasting and Longevity*** 

A Nature Cell Biology study across yeast, flies, mice, and humans reveals that fasting triggers longevity exclusively through spermidine?blocking spermidine synthesis ablates every lifespan-extending benefit, cardioprotection, and anti-inflammatory outcome, even with identical caloric restriction. Dave explains why your intermittent fasting protocol is metabolically inert without spermidine, the specific foods highest in bioavailable spermidine (wheat germ, aged cheddar, shiitake mushrooms, fermented foods), and how to time supplementation for maximum autophagy activation. This is the most critical missing variable in fasting-focused biohacking that almost no one is tracking. 

Sources: 

-https://www.nature.com/articles/s41556-024-01468-x 

-https://pubmed.ncbi.nlm.nih.gov/39117797/ 

-https://oxfordhealthspan.com/blogs/aging-well/spermidine-and-healthy-aging-insights-from-a-2026-nature-review 

-https://www.glp-1.science/blog/spermidine-autophagy-supplement/ 

 

***Hair Regrowth Breakthrough: SHH-Mimetic Peptides Replace Minoxidil*** 

Topical peptides mimicking sonic hedgehog signaling (the embryonic pathway that initiates hair follicles) activate dermal papilla stem cells and deliver 65% hair regrowth at 24 weeks versus 40% with minoxidil?with zero systemic absorption and zero cardiovascular risk. Dave covers why minoxidil's vasodilation mechanism is crude (and why it triggers tachycardia and hypertrichosis), how SHH-mimetic peptides directly target the actual biological lever (stem cell activation), and why this mechanistic upgrade should reshape hair loss treatment within 12 months. This is precision medicine applied to cosmetic optimization. 

Sources: 

-https://finance.yahoo.com/sectors/healthcare/articles/goodbye-minoxidil-clean-bio-hacking-150800494.html 

 

***"Sardinemaxxing": $1.39 Per Can Delivers 370% B12, 982mg Omega-3s, 96% Selenium*** 

Canned sardines are experiencing a viral surge on TikTok (#sardinemaxxing: 90,000+ videos) because a single 100-gram serving packs 370% daily B12, 982mg omega-3s, 96% selenium, and 24% vitamin D?all for $1.39. Dave breaks down the nutrient density to cost ratio (superior to wild salmon, fish oil supplements, and selenium stacks), the anti-inflammatory mechanisms (B12 methylation support, selenium-dependent glutathione peroxidase, omega-3 IL-6/TNF-? reduction), and why this represents a biohacker's efficiency play: maximum micronutrition per dollar with zero processing overhead. The shift from complexity back to simplicity. 

Sources: 

-https://news.northeastern.edu/2026/04/08/what-is-sardinemaxxing/ 

 

***Fluoride in Community Water Has No Effect on IQ or Cognition ? Wisconsin Longitudinal Study*** 

A seven-decade Wisconsin study tracking 10,317 people from age 16 through 80 finds zero evidence that community water fluoridation (0.7 mg/L, the U.S. recommended level) reduces IQ, impairs cognition, or causes neurotoxicity at any life stage. Dave distinguishes between community-level fluoridation and high-endemic-fluoride regions (2?10 mg/L in parts of Asia), clarifies why the anti-fluoridation narrative became culturally dominant without robust U.S. epidemiological data, and examines why 17+ states reversed fluoridation policy based on flawed evidence transfer. This is a case study in how folklore?even with mechanistic rationale?can override data. Individual choice about fluoride exposure remains valid; cognitive toxicity at community water levels is not supported. 

Sources: 

-https://www.sciencenews.org/article/fluoride-drinking-water-iq-no-evidence 

-https://www.nbcnews.com/health/kids-health/fluoride-water-children-iq-brain-cognition-study-rfk-jr-rcna267328 

-https://studyfinds.com/major-study-finds-no-link-between-fluoride-water-lower-iq/ 

-https://medicalxpress.com/news/2026-04-fluoride-kids-iq-decades-analysis.html 

-https://jamanetwork.com/journals/jamapediatrics/fullarticle/2828425 

-https://ntp.niehs.nih.gov/research/assessments/noncancer/completed/fluoride 

 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on immunotherapy breakthroughs, fasting optimization, cosmetic stem cell activation, nutrient density efficiency, and evidence-based policy reversals. Host Dave Asprey connects emerging clinical research, decade-long epidemiological data, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and distinguishing mechanistic wins from folklore-driven narratives. 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

Keywords: oncolytic virus therapy cancer, measles VSV immunotherapy, DIY biohacking immunotherapy, regulatory gatekeeping cancer treatment, spermidine fasting autophagy, spermidine longevity, intermittent fasting mechanism, wheat germ aged cheddar spermidine, SHH sonic hedgehog hair growth, dermal stem cell activation hair, minoxidil replacement peptide, hair regrowth mechanism, sardinemaxxing TikTok, sardines omega-3 B12 selenium, nutrient density cost ratio, nutrient bioavailability supplements, fluoride IQ study Wisconsin, community water fluoridation safety, fluoride high-exposure risk, anti-fluoridation evidence, biohacking news 2026, longevity research, mechanism-driven biohacking, performance optimization, healthspan extension 

 

Thank you to our sponsors!  

- The One Device | Use code DAVE for $10 off at theonedevice.com/dave 

- Viome | Check it out at viome.com and use code 10DAVE for 10% off. It?s time to stop guessing and start knowing your body. 

-iRestore | Grow thicker, healthier hair back naturally. Use code DAVE at irestore.com/DAVE 

Resources:   

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 ? Intro 

00:19 ? Virologist Self-Cures Cancer 

02:41 ? Fasting & Spermidine 

04:22 ? Hair Loss: Beyond Minoxidil 

06:08 ? Sardines as a Supplement Stack 

07:43 ? Fluoride & IQ: The 70-Year Study 

09:47 ? Final Thoughts 

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Your body already makes the most powerful wound-healing molecule on the planet, and now you can use it at home. This episode breaks down hypochlorous acid (HOCl), the compound your white blood cells produce naturally, and why it outperforms Neosporin, hydrogen peroxide, and synthetic antibiotics for everything from cuts and burns to eczema, rosacea, and chronic wounds. 

 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

-Grab a generous discount on your next purchase of Active Skin Repair by using code ?Dave? at: https://www.activeskinrepair.com  (good until May 21st)

 

Host Dave Asprey sits down with Justin Gardner, a 20-year leader in health, wellness, and regenerative medicine who has founded and sold multiple companies and introduced over 50 innovative products into hospitals and doctors' offices. When Justin discovered hypochlorous acid, he shifted his entire focus to making this medical-grade, non-toxic molecule available to the public, founding Active Skin Repair to give people a cleaner, more effective alternative to the chemical-laden products that dominate the skincare aisle. 

Dave and Justin cover the full biohacking case for HOCl: how it kills 99.9% of bacteria, viruses, and fungi in 15 seconds, why it does not trigger antibiotic resistance, how it avoids destroying the healthy growth factors that hydrogen peroxide nukes, and how it supports the skin microbiome instead of wrecking it. They also get into AI as a tool for functional medicine research, why the standard of care is the floor not the ceiling, and how smarter not harder approaches to wound care and chronic skin conditions are finally going mainstream. Dave shares the story of treating a mystery acid beetle wound from his Amazon trip using this exact compound, and why it belongs in every medicine cabinet alongside your supplements stack. 

You'll Learn: 

Why hypochlorous acid is 100 times more powerful than bleach but has the same safety profile as saline How HOCl mimics your immune system's own wound response instead of overriding it Why hydrogen peroxide and Neosporin can actually stall healing and damage your skin microbiome How HOCl disrupts biofilms in chronic wounds, sinuses, and on the skin during eczema flare-ups Why most HOCl products on the market contain little to no active ingredient How to use AI tools like Claude and Perplexity for functional medicine research that most doctors haven't done Why the US standard of care is the floor, not the ceiling, for anyone serious about longevity and anti-aging How to stack HOCl with red light therapy and other biohacking tools for faster recovery 

Thank you to our sponsors!      

- Viome | Check it out at https://www.viome.com/ and use code 10DAVE for 10% off. It?s time to stop guessing and start knowing your body. 

- The One Device | Use code DAVE for $10 off at https://www.theonedevice.com/dave 

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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Justin Gardner, Active Skin Repair, hypochlorous acid, HOCl, wound healing, skin repair, antimicrobial, biofilm, eczema, rosacea, acne, skin microbiome, regenerative medicine, functional medicine, biohacking, anti-aging, human performance, longevity, supplements, AI healthcare, Dave Asprey, Neosporin alternative, natural healing, chronic wounds, skin inflammation, topical antibiotics, wound care, clean skincare, medical grade skincare, smarter not harder 

Resources:   

? Get A Discount On Active Skin Repair By Using Code ?Dave? At: https://www.activeskinrepair.com  (good until May 21st)

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 ? Trailer 

00:47 ? Dave's Injury Story 

01:55 ? What Is Hypochlorous Acid? 

02:41 ? HOCl vs. Neosporin 

03:23 ? History of HOCl 

04:49 ? HOCl vs. Hydrogen Peroxide 

06:19 ? Off-Label Use 

08:41 ? Skin Microbiome 

15:29 ? Chronic & Slow-Healing Wounds 

16:30 ? HOCl for Eczema & Rosacea 

18:31 ? Skincare Industry Problems 

21:38 ? Integrity in Product Design 

28:24 ? Using AI for Health Research 

34:17 ? GHB, Pharma & Suppressed Compounds 

35:58 ? Wrap-Up & Discount Code 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The government is finally catching up to what biohackers have known for decades, and the man helping lead that charge just sat down with Host Dave Asprey to talk longevity science, aging biomarkers, dietary overhaul, AI in medicine, and what a real science-first health agenda actually looks like. 

 

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Jim O'Neill served as Deputy Secretary of Health and Human Services and Acting Director of the CDC before being nominated to lead the National Science Foundation in March 2026. Before entering government, he was CEO of SENS Research Foundation, where he led cutting-edge regenerative medicine research targeting mitochondrial mutations, senescent cells, and neocortex rejuvenation. He is a 30-year veteran of health care reform and a genuine longevity insider. 

Dave and Jim cover the complete rewrite of federal dietary guidelines, the government's new randomized controlled trials on saturated fats, and why grains are no longer the core of a "balanced diet." They dig into a 144 million dollar ARPA H program to establish causal aging biomarkers that will unlock real anti-aging drug development and accelerate the kind of longevity research the SENS Foundation pioneered. Jim explains why current aging clocks and DNA methylation markers are not enough, and what comes next for functional medicine, sleep optimization, and metabolism research. They also break down the CDC's return to its infectious disease core, the future of AI in health care, wearable data for disease surveillance, organ bioprinting, GLP-1s, supplements like vitamin D, peptides, and the right to self-experiment. 

You will learn: 

Why the new federal dietary guidelines finally reject grain-centric nutrition and validate what the biohacking world has argued for 25 years How a 144 million dollar government program aims to build the causal biomarkers that will make real anti-aging and longevity drug development possible What Jim thinks about DNA methylation clocks and why better tools are needed to measure aging and human performance How AI is reshaping prescription refills, clinical decision support, Medicare reimbursement, and the future of functional medicine Why Jim wears an Oura Ring and uses sleep optimization data to make daily health decisions The government's evolving stance on peptides, supplements, and therapies that are not patent protected How organ bioprinting using a patient's own cells could solve the organ shortage crisis What real science replication looks like and why the government is now funding it What the CDC is doing to refocus on infectious disease while shedding mission creep How GLP-1s, fitness tracking, and updated nutrition strategies could significantly cut national obesity rates within five years 

 

Thank you to our sponsors!      

- Neuronic | Go to www.neuronic.online Code DAVE for $100 off 

- iRestore | Reverse hair loss with www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE 

- Go to timeline.com/dave and save 20% with code DAVE20 

- Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Jim O'Neill, CDC, HHS, dietary guidelines, saturated fat, aging biomarkers, ARPA H, SENS Research Foundation, longevity, anti-aging, senescent cells, mitochondria, DNA methylation, sleep optimization, Oura Ring, AI healthcare, organ bioprinting, GLP-1, peptides, vitamin D, supplements, functional medicine, biohacking, Dave Asprey, human performance, metabolism 

Resources:   

? Learn more at: https://www.hhs.gov/ 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps: 

00:00 ? Trailer 

01:15 ? Dietary Guidelines Overhaul 

06:48 ? Misinformation & Scientific Integrity 

10:26 ? Longevity vs. Chronic Disease 

13:03 ? Aging Biomarkers & ARPA-H 

14:31 ? CDC's Refocus on Infectious Disease 

16:55 ? Alternative Therapies & Biohacking 

19:21 ? Health Trackers & Privacy 

22:27 ? AI in Healthcare 

24:01 ? Diet, Supplements & School Meals 

27:31 ? Food Safety, Pesticides & Peptides 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

My favorite creatine (discount code DAVETUBE): https://www.qualialife.com/ASPREYRECOMMENDS

Creatine isn?t just for bodybuilders. It?s one of the most overlooked, science-backed nootropics for brain optimization, neuroplasticity, mitochondrial energy, and total human performance. This episode reveals why creatine is a non-negotiable supplement for anyone serious about biohacking, longevity, and cognitive upgrades.

Host Dave Asprey breaks down the myths and truths about creatine, uncovering how it enhances memory, supports your mitochondria, regulates mood, strengthens bones and heart function, and even aids fetal brain development during pregnancy. Drawing from decades of functional medicine, real-world biohacks, and new research featured in the Wall Street Journal, Dave explains how creatine works not only as a muscle booster but as a universal cellular fuel that supports brain benefits, memory improvement, and sleep optimization.

Timestamps:

0:00 ? Introduction

1:14 ? Why Creatine Matters

5:01 ? History of Creatine

6:09 ? Debunking the Myths

8:55 ? 5 Ways Creatine Fuels Your Mind & Body

16:25 ? How to Maximize Absorption

18:13 ? Dosing: How Much & When to Take It

19:07 ? Forms of Creatine Explained

19:50 ? Special Use Cases

21:28 ? Biohacking Real-World Applications

23:21 ? What to Stack with Creatine

24:50 ? Choosing the Right Creatine

28:40 ? Recap & Key Takeaways

Thank you to our sponsors!

 Viome | Check it out at viome.com and use code 10DAVE for 10% off. It?s time to stop guessing and start knowing your body.AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

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Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey?s BEYOND Conference: https://beyondconference.com/

Dave Asprey?s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week's stories: 

*Bartonella Hides in Cat Scratches ? and It Might Be Why You Feel Like Garbage 

A stealth bacterial infection transmitted by everyday cat scratches and flea dirt has been quietly linked to chronic fatigue, brain fog, and neurological symptoms for decades. Dave breaks down how Bartonella slips past standard testing, why it's almost never on a conventional doctor's radar, and the specific PCR protocol you need to actually find it. 

Sources: 

https://pubmed.ncbi.nlm.nih.gov/ 

 

*High Tyrosine Levels May Be Cutting Years Off Men's Lives 

A Mendelian randomization study of 270,000 UK Biobank participants found that elevated tyrosine is causally linked to nearly a full year of lost lifespan in men ? with zero effect in women. The culprit appears to be an inflammatory oxidation pathway that men metabolize very differently. Dave examines what this means for every guy stacking L-tyrosine nootropics or eating high-protein keto. 

Sources: 

https://pubmed.ncbi.nlm.nih.gov/41045493/ https://www.aging-us.com/news-room/high-tyrosine-levels-linked-to-shorter-lifespan-in-men https://www.usnews.com/news/health-news/articles/2026-02-27/study-suggests-one-common-amino-acid-may-affect-how-long-men-live 

 

*Blue Light Blocking Contact Lenses Are a Legitimate Vision Upgrade 

ALTIUS Vision's tinted contact lenses aren't just blue light filters ? they cut chromatic aberration by 53% and improve motion tracking and contrast sensitivity in ways that software filters simply can't replicate. Dave covers the mechanism, who benefits most (screen workers, TBI recovery, gamers), and how to find a provider. 

Sources: 

https://altiusvision.com/chromatic-aberration/ https://altiusvision.com/science-of-altius/ https://www.westvalleyvision.com/-altius--performance-tinted-contact-lenses 

 

*Taurine Plus B Vitamins Actually Moves the Needle on Motivation 

A randomized crossover trial found that a daily stack of taurine, B6, folate, and B12 sustained effort-reward motivation and cut cognitive lapses significantly compared to placebo ? and the mechanism runs through glutathione production in brain astrocytes. Dave breaks down why this combo works when either ingredient alone doesn't. 

Sources: 

https://pubmed.ncbi.nlm.nih.gov/41889717/ https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1711478/full https://www.nutraingredients.com/Article/2026/03/23/taurine-and-b-vitamins-bost-motivation-and-focus/ 

 

*30 Seconds of Smelling Flowers Resets Your Nervous System 

Research out of the Monell Chemical Senses Center confirms what your grandmother knew: a slow, deep floral inhale measurably lowers heart rate and activates the parasympathetic nervous system ? and it works because olfaction bypasses the cortex entirely and hits the limbic system directly. Dave makes the case for building a daily scent ritual. 

Sources: 

https://time.com/ https://www.southtabor.com/healthy-living-tip-stop-and-smell-the-flowers/ 

 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on infection-driven cognitive decline, amino acid optimization, sensory performance, and evidence-based supplementation. Host Dave Asprey connects emerging clinical research, Mendelian randomization data, and real-world protocols into actionable frameworks for extending healthspan and sharpening performance. 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

Keywords: Bartonella cat scratch infection, Bartonella brain fog chronic fatigue, stealth bacterial infection biohacking, tyrosine lifespan men, L-tyrosine risk men longevity, Mendelian randomization amino acid aging, blue light blocking contacts, ALTIUS vision chromatic aberration, performance contact lenses TBI, taurine B vitamins motivation RCT, taurine folate brain health, glutathione astrocytes focus, smelling flowers heart rate stress, olfaction parasympathetic nervous system, floral scent limbic system, biohacking news, longevity research 2026 

Thank you to our sponsors!  

- GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what?s in your air. 

- MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. 

- iRestore | Grow thicker, healthier hair back naturally. Use code DAVE at irestore.com. 

Resources:   

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com    

Timestamps: 

00:00 ? Intro 

00:37 ? Bartonella & Cat Scratch Disease 

02:06 ? Tyrosine & Lifespan in Men 

03:37 ? Tinted Contacts & Visual Processing 

05:56 ? Taurine & Motivation 

07:25 ? Floral Scent & Nervous System Reset 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most women are suffering for years from anxiety, gut problems, low libido, and brain fog because no one is treating the real cause: their hormones. This episode is a masterclass in women's hormone optimization, covering everything from vaginal delivery of bioidentical hormones to why low estrogen destroys your gut, your sex drive, your mitochondria, and your marriage. 

 

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Sarah Daccarett, MD, a physician, longevity expert, and the founder and CEO of Inner Balance, a modern women's health company redefining hormone therapy, sexual wellness, and aging. She has treated tens of thousands of women across all 50 states and is known for challenging outdated medical models and building science-driven solutions that reflect female biology rather than borrowing protocols designed for men. She created Oestra, a revolutionary hormone therapy delivery system, along with Libida, an on-demand libido solution that targets desire at the brain level, making her one of the most credible and innovative voices in functional medicine and women's longevity today. 

Together, they expose why conventional medicine has failed women for decades, why patches and pills are nearly useless, and what actually works for anti-aging, metabolism, longevity, and human performance. Dr. Sarah makes the case that hormone replacement therapy is not a last resort for menopausal women. It is a foundational longevity strategy that every woman should consider starting in her 20s. 

You'll Learn: 

Why vaginal hormone delivery outperforms every other delivery method for women How low estrogen destroys your gut lining, gallbladder, and immune system long before menopause symptoms appear Why a carnivore or animal-based diet raises estrogen and why fiber lowers it How progesterone converts to testosterone in women, and why you may not need a testosterone prescription The real reason SSRIs get prescribed when hormone replacement therapy should come first Why iodine is essential for breast health, estrogen metabolism, and thyroid function How oxalates from "superfoods" like matcha, spinach, and almonds accumulate in your ovaries, uterus, and kidneys Why both partners need hormone replacement therapy for a relationship to thrive How hormones control mitochondria, dopamine, norepinephrine, and every system in your body 

Thank you to our sponsors!      

- Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off. 

- Igniton | Try risk free at Igniton.com and use code DAVE at checkout for 15% off. Backed by a 30-day money back guarantee. 

- The One Device | Use code DAVE for $10 off at theonedevice.com/dave 

- Joymode | Go to tryjoymode.com/DAVE Or enter DAVE at checkout for 20% off.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Dr. Sarah Daccarett, Inner Balance, women's hormone therapy, bioidentical hormones, vaginal hormone delivery, estrogen deficiency, progesterone therapy, hormone replacement therapy, perimenopause, testosterone women, COMT genetics, FSH hormone, iodine deficiency, oxalates health, leaky gut hormones, women's longevity, biohacking, Dave Asprey, human performance, functional medicine, anti-aging 

Resources:   

? Visit Sarah?s Website and use code ?PODCASTDRSARAH?: https://www.innerbalance.com/ 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps: 

0:00 ? Trailer 

1:15 ? Introduction 

2:43 ? The Gender Gap in Hormone Care 

5:14 ? Why Women's Hormone Therapy Is Stuck in the 1960s 

8:09 ? Why Young Women Are Losing Their Hormones 

9:33 ? Toxins, Birth Control & Hormone Disruption 

14:07 ? How Fiber Steals Your Hormones 

19:53 ? Hormones, Libido & Brain Chemistry 

32:13 ? Pills, Patches & Why They Fail 

36:54 ? Why Vaginal Delivery Works Best 

44:36 ? Symptoms of Low Hormones 

46:07 ? Leaky Gut Is a Hormone Problem 

47:38 ? How Low Hormones Destroy Relationships 

52:28 ? Thyroid, Iodine & Sex Hormones 

1:00:29 ? Progesterone for Men 

1:05:18 ? Oxalates, Kidney Stones & Your Diet 

1:11:13 ? Where to Find Dr. Sarah 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

I spent over $2 million hacking my own biology to reverse my age, but one of the most powerful discoveries didn?t come from a pharmaceutical lab. It came from NASA.

Try Danger Coffee: https://dangercoffee.com/dave (Discount Code DAVETUBE)

Try Energy Bits: https://energybits.com/discount/dave

Astronauts face the harshest environment known to science: space radiation. To keep them alive, NASA had to identify a nutrient dense enough to protect DNA and mitochondria from extreme oxidative stress. They found it in algae (spirulina and chlorella)?a superfood older than civilization that acts as "biological armor" for your cells.

In this episode, I break down why "aging" is actually just a buildup of oxidative stress (cellular rust) and how most antioxidants fail to fix it because they never reach the mitochondria. I reveal the exact science behind why algae works, the specific molecules (phycocyanin and chlorophyll) that protect your cellular walls, and the protocol I use to keep my liver young and my energy stable.

We also cover the critical lifestyle factors?from sleep to seed oils?that are throwing gasoline on the fire, and how to "clear the battlefield" so this superfood can actually do its job

Timestamps:

00:00 ? Intro

01:03 ? The Aging Myth

01:43 ? How Aging Actually Starts

03:33 ? Restoring Your Antioxidant Defense

04:56 ? Why Most Supplements Fail

07:30 ? NASA's Superfood Discovery

11:47 ? How to Use Algae

13:24 ? Lifestyle Factors That Undermine Algae

15:57 ? Action Plan

Thank you to our sponsors!

Danger Coffee | Grab yours at DangerCoffee.com and use code DAVEPOD at checkout for 15% off.The One Device | Use code DAVE for $10 off at theonedevice.com/dave.

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey?s BEYOND Conference: https://beyondconference.com/

Dave Asprey?s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your home could be quietly stealing your IQ, disrupting your hormones, destroying your mitochondria, and triggering chronic disease, and most people never connect the dots. This episode gives you the full picture on toxic mold, and exactly what to do about it 

Learn More About The Superstratum Products Dave Uses At: https://superstratumlabs.com/products/dave 

Host Dave Asprey sits down with Seth Jones, CEO of Superstratum and the creator of the first patent-pending process to remove mycotoxins from homes. Before founding Superstratum, Seth spent 15 years as an international songwriter, producer, and DJ until a personal experience with Building-Related Illness changed the entire direction of his life. Today he and his team are on a mission to heal the estimated 66 million homes in the U.S. that create toxic conditions for the 170 million people living inside them. If toxic mold has derailed your health, your relationships, or your ability to think clearly, this conversation will change how you see your home forever. 

Dave Asprey built his entire biohacking and longevity career trying to fix what mold did to his body. By his mid-twenties, he carried diagnoses of arthritis, chronic fatigue, fibromyalgia, and mold-induced brain damage that wiped out his prefrontal cortex activity. Functional medicine doctors couldn't help him. Specialists gave up. It took him years of self-directed research into mitochondria, metabolism, and environmental toxicology to understand that his home was the root cause. He lost 100 pounds, reversed brain damage confirmed by imaging, and recovered IQ points he thought were gone for good. 

In this episode, Dave and Seth break down the real science of how mycotoxins poison mitochondria, hijack hormones, crush sleep optimization, and block the neuroplasticity your brain needs to perform. They reveal why mold is additive with every other toxin in your environment, why most remediation fails, and how a systematic home detox protocol can do what no supplement, nootropic, or fasting protocol can fix on its own. 

You'll Learn: 

Why mold toxins are direct mitochondrial poisons and what that means for your energy, willpower, and metabolism How mycotoxins lower your IQ by up to 15 points and why removing them reverses the damage The estrogen-mimicking mold toxin 10,000 times stronger than human estrogen that causes weight gain no diet can fix Why your AC and HVAC system are the most dangerous mold delivery systems in your home How mold disables detox pathways and makes every other environmental toxin worse The connection between toxic mold, Lyme disease, Alzheimer's, cancer, and fertility loss Why Danger Coffee and mold-free nutrition matter as much as fixing your home The step-by-step Superstratum protocol for fogging, bombing, coating, and restoring a healthy home microbiome How to salvage your belongings, treat your car, and avoid recontaminating a clean environment 

Thank you to our sponsors!     

- Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today 

- Superstratum Labs | Get Dave's exact home mold detox kit and save 10% with code DAVEASPREY superstratumlabs.com/products/dave 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Seth Jones, Superstratum, toxic mold symptoms, mycotoxins in homes, Building-Related Illness, mold and IQ, mold brain damage, HVAC mold, home detox protocol, hypochlorous acid mold, environmental probiotics, HomeBiotic, mold and mitochondria, mold and hormones, zearalenone estrogen, mold weight gain, mold and fertility, mold and Alzheimer's, mold and Lyme disease, ochratoxin, mold and chronic fatigue, Dave Asprey, biohacking, longevity, functional medicine, human performance, anti-aging, Danger Coffee, mold detox, brain optimization, sleep optimization 

Resources:   

? Learn More About The Superstratum Products Dave Uses (discount code DAVEASPREY): https://superstratumlabs.com/products/dave 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps: 

00:00 ? Trailer 

00:46 ? Intro 

01:27 ? Dave's Mold Origin Story 

02:37 ? Health Decline & Recovery 

06:02 ? Coffee, Bulletproof & Moldy Movie 

10:17 ? Systemic Effects of Mold 

13:24 ? Introducing SuperStratum 

18:04 ? Weight, Hormones & Brain Damage 

19:53 ? Brain Scans, Sleep & Symptoms 

26:09 ? Fertility, Prevention & Costs 

31:03 ? Treating the Home 

42:42 ? Seth's Story 

48:45 ? Resources & Car Detox 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Autism is reversible, and the science to prove it already exists. This episode delivers a master class on the biological roots of autism, what actually triggers it, and the protocols that have helped real families recover their children, including one mom who sold everything she owned to make it happen. 

Host Dave Asprey sits down with Tracy Slepcevic, bestselling author of Warrior Mom: A Mother's Journey in Healing Her Son with Autism, certified integrative health practitioner, Air Force veteran, and founder of Autism Health, a 501(c)(3) nonprofit organization dedicated to accelerating biomedical solutions for autism. Tracy has spent over 17 years researching treatments and therapies for autism and other neurological disorders, trained in complementary and alternative medicine, and built the Autism Health Summit into one of the most important annual gatherings for parents, physicians, and researchers in the autism recovery space. She is not a researcher observing from a distance. She is a mother who sold everything she owned, bartered for treatments, and traveled to Ukraine for stem cell therapy to recover her son Noah, who today lives a fully independent life, works full time, and travels the world alone. 

Together, Dave and Tracy tear apart the myth that autism is a fixed genetic condition and expose it for what it actually is: a biological cascade triggered by a recipe of environmental factors colliding with genetic susceptibility. They cover how mitochondrial dysfunction and chronic neuroinflammation combine to create the sensory overload and cognitive fog that defines autism, why healing the gut first is the non-negotiable foundation that determines whether every other treatment works, how glyphosate, toxic mold, heavy metals, volatile organic compounds, and vaccine injury each contribute to a compounding toxic load that crosses the threshold into autism, why plasmalogen supplements are producing results in non-speaking children that the medical establishment insists are impossible, and how AI is now accelerating the ability of parents and practitioners to identify personalized biological pathways and act on them in hours instead of months. Dave also shares his own journey reversing Asperger's syndrome over ten years through biology, mitochondrial repair, neuroplasticity retraining, and supplements, and explains why catching these conditions early and acting on them aggressively with functional medicine is the difference between a life of suffering and a life of superpowers. 

You'll Learn: 

Why autism is biological, not purely genetic, and what environmental triggers pull the trigger on susceptible children How mitochondrial collapse creates the energy deficit that drives sensory overload, social withdrawal, and cognitive dysfunction in autism Why healing the gut first determines whether every other autism treatment works or fails What plasmalogen supplements are doing for non-speaking children and adults with neurological disorders How glyphosate, toxic mold, heavy metals, and volatile organic compounds compound into the recipe that causes autism Why AI is transforming the ability of autism parents to identify personalized amino acid and supplement protocols overnight How Dave reversed Asperger's syndrome through mitochondrial repair, neuroplasticity retraining, and targeted supplements What stem cell therapy accomplished for Tracy's son Noah within 30 days of treatment Why genetic testing before any vaccine or medication schedule should be mandatory for every child How to clean your home environment of the VOCs, mold, and bacterial toxins that drive neuroinflammation in the whole family Why the gifts that come with an autism diagnosis can become genuine superpowers once the biology gets fixed 

Thank you to our sponsors!     

- BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. 

- AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers. 

- Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18. 

- Timeline | Go to timeline.com/dave and you?ll get an additional 20% off your first month 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Tracy Slepcevic, Warrior Mom book, autism recovery, biomedical intervention autism, autism gut health, mitochondrial dysfunction autism, plasmalogen supplements, stem cell therapy autism, glyphosate autism, toxic mold neuroinflammation, vaccine injury autism, Autism Health Summit, heavy metals autism, neuroplasticity, biohacking, Dave Asprey, functional medicine, anti-aging, human performance, brain optimization 

 Resources:   

? Visit Tracy?s Website To Learn More: www.AutismHealth.com 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps: 

0:00 ? Trailer 

1:15 ? Dave's Personal Autism Journey 

4:26 ? What Causes Autism 

8:20 ? Gut Health as the Foundation 

10:14 ? Tylenol, Vaccines & Toxic Exposures 

12:21 ? The Gifts & Superpowers of Autism 

15:42 ? AI, Peptides & Plasmalogen 

22:06 ? Mold, Lyme & Toxic Load 

27:57 ? Top Autism Contributors 

31:04 ? Cleaning Up Your Environment 

33:35 ? Glial Cells & Neuroinflammation 

39:27 ? Tracy's Story & Noah's Diagnosis 

51:55 ? Warrior Mom: Sacrifice & Recovery 

54:08 ? Vaccines & the Coverup 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most people buying "clean" supplements are unknowingly loading their bodies with heavy metals, rancid fish oil, and glyphosate, even inside products labeled organic and healthy. This episode breaks down exactly what the supplement industry refuses to tell you and gives you the tools to stop poisoning yourself every morning. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

-Grab a discount on Puori Products by visiting: https://puori.com/pages/dave?dt_id=1750934 

Host Dave Asprey sits down with Oliver Amdrup-Chamby, founder and CEO of PUORI and a serial entrepreneur in the health and wellness space with over 16 years building what has become one of the most rigorously tested supplement brands in the world. Oliver opened the first CrossFit gym in Denmark in 2006, served as Regional Director of CrossFit HQ across Europe and the Middle East, holds an Executive Program credential from Stanford, and advises longevity projects including One Thirty Labs in Copenhagen. He founded PUORI in 2009 with a single obsession: creating the cleanest third-party tested fish oil on the market. That obsession grew into a full supplement line built on batch testing every finished consumer product for environmental toxins, a standard the industry has yet to catch up to. 

Together, Dave and Oliver expose the hidden contamination crisis inside the supplement industry, from oxidized fish oil that creates inflammation instead of fighting it, to plant-based protein powders carrying up to 10 times more heavy metals than whey. They break down why organic does not mean safe, how glyphosate embeds itself directly into your collagen infrastructure and disrupts the body's ability to build healthy connective tissue, and why the omega 3 index is one of the most powerful and measurable longevity biomarkers you are probably ignoring. They also dig into the surprising brain optimization and anti-aging benefits of creatine, including new research on concussion recovery and sleep deprivation, and how foundational supplements like vitamin D, magnesium, and high-quality fish oil remain the non-negotiables that no nootropic stack can replace. 

You'll Learn: 

Why organic protein powder often contains more heavy metals than non-organic options How glyphosate infiltrates collagen and gets rebuilt into your body's own tissue What the omega 3 index is, why most Americans are dangerously low, and how raising it correlates with years of additional longevity Why plant-based omega 3s fail to convert to DHA and what to take instead How oxidized fish oil creates inflammation rather than reducing it, and what to look for on the label Why vitamin D deficiency persists even with regular sun exposure and how genetics affect your required dose The creatine research that has longevity doctors and neuroscientists paying attention for the first time How foundational supplements support mitochondria, metabolism, and long-term resilience in ways that trendy biohacking stacks cannot replicate What to look for in a clean supplement brand and why third-party batch testing of finished goods is the only standard that matters 

 

Thank you to our sponsors!      

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Oliver Amdrup-Chamby, PUORI supplements, fish oil oxidation, omega 3 index, heavy metals protein powder, glyphosate collagen, organic protein powder toxins, foundational supplements, creatine brain health, vitamin D deficiency, clean label testing, longevity supplements, biohacking, Dave Asprey, anti-aging, human performance, functional medicine, supplement transparency, plant-based protein heavy metals, whey protein 

Resources:   

? Grab a discount on Puori Products by visiting: https://puori.com/pages/dave?dt_id=1750934 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps: 

0:00 ? Trailer 

0:47 ? Introduction 

2:19 ? Foundational vs. Sexy Supplements 

4:33 ? Omega-3 Index Explained 

5:45 ? Vegan Omega-3s & DHA 

7:39 ? Fish Oil Oxidation 

8:48 ? Batch Testing & Industry Transparency 

16:03 ? Storing Fish Oil Properly 

17:30 ? Vitamin D, Magnesium & Fish Oil Stack 

19:11 ? Vitamin D Dosing & Genetics 

21:34 ? RDAs & Government Nutrition Advice 

23:06 ? Glyphosate in the U.S. Food Supply 

26:40 ? Heavy Metals in Fish Oil 

37:44 ? Protein Powders & Heavy Metals 

45:52 ? Creatine for Brain & Concussion 

48:48 ? TrueDark & Brain Recovery 

51:24 ? Brain Scanning 

53:58 ? Toxins in Plant vs. Animal Protein 

56:30 ? Collagen: Sourcing & Glyphosate Risk 

1:02:26 ? Outro & PUORI Discount 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBE

I have spent 20 years and over $2 million testing my biology, and the biggest lesson I've learned is that sleep is a neurological system, not just a chemical one. Most people fail to get deep rest because they are stuck in Beta brainwaves?a state of hypervigilance fueled by stress and blue light. You can take all the melatonin in the world, but if your brain is electrically "awake," you will stay "tired but wired."

The "switch" I use to fix this is an amino acid called L-theanine. It crosses the blood-brain barrier to increase Alpha waves, which quiet the prefrontal cortex and stop overthinking. By boosting GABA and lowering glutamate, it prepares the brain for rest without the groggy "hangover" of traditional sedatives.

To make this work, I follow a strict protocol: taking 400mg?1000mg about 45 minutes before bed on an empty stomach. I also protect my "Alpha state" by blocking blue and green "junk light" with TrueDark glasses, which prevents cortisol spikes that ruin sleep architecture. When you combine the right compounds with a dark, low-stimulation environment and consistent timing, sleep stops being something you chase and becomes something your body does automatically.

Timestamps:

00:00 ? Introduction

00:23 ? How the Brain Enters Sleep

01:00 ? Why Most Supplements Fail

02:15 ? Beta Waves: The Sleep Blocker

03:29 ? Alpha Waves: The Sleep Gateway

04:51 ? The Amino Acid That Shifts Your Brain

06:11 ? Introducing L-Theanine

06:48 ? Common L-Theanine Mistakes

08:02 ? The Right Protocol

09:34 ? Light & Your Sleep Environment

11:13 ? Fixing Your Light Environment

12:14 ? The Full Sleep System

13:59 ? Putting It All Together

Thank you to our sponsors!

AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser.

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey?s BEYOND Conference: https://beyondconference.com/

Dave Asprey?s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your brain is hardware, and if the hardware is broken, no supplement stack, nootropic, or biohacking protocol in the world will get you to full capacity. This episode goes inside the most advanced stem cell and brain optimization clinic on the planet, where Host Dave Asprey undergoes a cutting-edge neurocognitive protocol that combines focused ultrasound, transcranial magnetic stimulation, and mesenchymal stem cells to target specific regions of the brain with millimeter precision.  

- Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

- Learn more about all the treatments at RMI by visiting: https://daveasprey.com/rmi/ 

Dr. Victor Urzola is a plastic and reconstructive surgeon with training from the University of Milan, microsurgery credentials from University Henri Poincare in France, and fellowship experience in facial aesthetic surgery and body contouring on both sides of the Atlantic. He is the former president of the Costa Rican Society of Plastic Surgery and holds membership in the Italian, European, and American societies of plastic and aesthetic surgery. As co-founder of RMI Clinic in Costa Rica, Dr. Urzola has spent years pushing the frontier of regenerative medicine, applying the rigor of academic surgical training to stem cell therapy, neurocognitive protocols, and longevity treatments that most clinics in the world are not yet attempting. 

Dave and Dr. Urzola break down how neuroinflammation silently degrades cognitive function the same way joint inflammation destroys athletic performance, and why treating the brain like a biological system you can upgrade changes everything. They cover the full RMI longevity protocol Dave completed in Costa Rica, including the neurocognitive brain upgrade, plasmapheresis for full-body anti-aging, orthopedic stem cell joint repair, and yes, the enhanced protocol Dave has become known for discussing without apology. 

This is next-level biohacking and regenerative medicine for anyone serious about brain optimization, longevity, and upgrading every system in the body before problems become permanent. 

You'll Learn: 

How RMI uses functional MRI, neuronavigation, and focused ultrasound to target hypofunctioning brain regions with millimeter accuracy Why neuroplasticity and cognitive recovery in dementia patients improved after just 15 days of treatment How plasmapheresis removes pro-inflammatory mediators and toxins from your entire vascular system and why Dave does it annually What shockwave therapy combined with stem cell injection accomplishes for both men and women in ways pharmacological treatment cannot Why cell viability and placement matter more than raw cell count, and how RMI measures both 10 minutes before every injection How orthopedic stem cell protocols achieve 82.5 percent improvement in joint function across 8,000 treated joints Why Dave calls RMI the best hardware upgrade available and 40 Years of Zen the best software upgrade, and how the two work together What the difference feels like between going from standard resolution to 4K inside your own brain 

Thank you to our sponsors!     

- HeartMath | Go to https://www.heartmath.com/dave to save 15% off. 

- EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Victor Urzola, RMI Clinic Costa Rica, stem cell therapy, brain optimization, neurocognitive protocol, focused ultrasound, transcranial magnetic stimulation, neuroinflammation, plasmapheresis, orthopedic stem cells, mesenchymal stem cells, blood brain barrier, regenerative medicine, anti-aging, longevity, biohacking, Dave Asprey, erectile dysfunction treatment, stem cell facelift, human performance 

Resources:   

? Learn More About All Of The Treatments at RMI by visiting: https://daveasprey.com/rmi/ 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 ? Trailer 

01:02 ? Introduction and RMI Overview 

03:02 ? Cognitive Protocol Explained 

05:39 ? Dave's Brain Treatment Experience 

13:08 ? RMI Results & Patient Outcomes 

15:32 ? Plasmapheresis (Blood Cleanse) 

17:10 ? Orthopedic Stem Cell Treatments 

23:49 ? Enhanced Protocol (Sexual Health ? Men) 

25:29 ? Sexual Health ? Women 

27:40 ? Facial Stem Cell Treatment 

30:05 ? Closing & Resources 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the real reason you feel stuck, anxious, or unfulfilled has nothing to do with your biohacking stack and everything to do with which half of your brain you're actually using? In this episode, Host Dave Asprey sits down with Harvard professor and bestselling author Arthur Brooks to reveal the neuroscience of meaning, consciousness, and why your left brain's obsession with optimization is quietly destroying your happiness and human performance. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

- Buy Arthur?s new book ?The Meaning Of Your Life? at: https://www.penguinrandomhouse.com/books/724315/the-meaning-of-your-life-by-arthur-c-brooks/ 

Arthur Brooks is a professor at both the Harvard Kennedy School and Harvard Business School, where he teaches leadership and happiness. He writes the wildly popular "How to Build a Life" column at The Atlantic, hosts the weekly podcast "Office Hours with Arthur Brooks," and has authored 15 books, including two number one New York Times bestsellers: Build the Life You Want with Oprah Winfrey, and From Strength to Strength. His new book, The Meaning of Your Life: Finding Purpose in an Age of Emptiness, releases March 31, 2026. Brooks is one of the world's foremost experts on the science of human happiness. 

Dave and Arthur go deep on hemispheric lateralization, the rediscovered neuroscience showing your right brain holds everything that makes life worth living: meaning, mystery, consciousness, and the ineffable experiences that no AI, no nootropic, and no amount of fasting or sleep optimization can manufacture for you. They break down why the depression and anxiety epidemic is really a right-brain deficiency crisis, and why all the supplements, ketosis protocols, and functional medicine hacks in the world won't fix it if you're living entirely in your left hemisphere. 

This is a rare episode that bridges hard neuroscience with the deepest questions of human existence. Whether you're deep into anti-aging, neuroplasticity training, or Smarter Not Harder living, this conversation will change how you think about what you're actually optimizing for. 

You'll Learn: 

Why the mental health crisis is fundamentally a meaning crisis, and what your brain hemispheres have to do with it How technology, AI, and screen culture are suppressing the right hemisphere and wiring you for anxiety The six scientifically backed ways to open your right brain and unlock experiences of real meaning Why self-improvement fails without first understanding the neuroscience of how ideas install in the brain How suffering, handled correctly, is the single most powerful path to consciousness and purpose Why romantic love, beauty, and deep conversation are forms of neurological medicine What Dave's $2.5 million biohacking journey taught him about the limits of optimization The Buddhist physics of suffering: pain times resistance, and how to lower the resistance instead of the pain 

 

Thank you to our sponsors!     

- Danger Coffee | Grab yours at DangerCoffee.com and use code DAVEPOD at checkout for 15% off. 

- Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. 

- Join My Low-Oxalate 30-Day Challenge: daveasprey.com/2026-low-ox-reset 

- Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  

Keywords: Arthur Brooks, Harvard happiness research, meaning of life, hemispheric lateralization, right brain left brain, brain optimization, neuroplasticity, consciousness neuroscience, mental health crisis, depression anxiety solutions, human performance, self-improvement science, longevity mindset, biohacking happiness, Dave Asprey, functional medicine, suffering and purpose, AI limits, meaning and purpose, How to Build a Life 

Resources:   

? Buy Arthur?s new book ?The Meaning Of Your Life? at: https://www.penguinrandomhouse.com/books/724315/the-meaning-of-your-life-by-arthur-c-brooks/ 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 ? Trailer 

00:49 ? Introduction 

02:09 ? Teaching & Learning Science 

07:05 ? Consciousness & Brain Hemispheres 

18:51 ? Mental Health & Meaning Crisis 

20:08 ? 6 Ways to Open the Right Brain 

21:44 ? Deep Questions & Life's Purpose 

27:16 ? Romantic Love & Relationships 

34:37 ? Transcendence & Self 

41:18 ? Finding Your Calling 

49:33 ? Beauty 

53:41 ? Suffering & Meaning 

57:20 ? Closing 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people have no idea how broken theirs actually is. 

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Get 20% off your next purchase of OMNi-BiOTiC with code ?Dave20? at: https://omnibioticlife.com/ 

In this episode, Host Dave Asprey and microbiome expert Hannah Kleinfeld break down the hidden gut science behind GLP-1 drugs, ADHD, HRV, histamine intolerance, SIBO, and why most probiotics you're taking are probably dead before they even reach your intestines. 

Hannah Kleinfeld is the co-founder and COO of Omni-Biotic US, a Yale and Harvard graduate, and a certified health coach whose personal battle with Lyme disease drove her deep into functional medicine and microbiome science. Omni-Biotic is the number one probiotic brand in Europe, used in hospital systems alongside antibiotic treatment, and is now bringing that clinical-grade research to the US market. 

Dave and Hannah go deep on the gut-brain axis, the vagus nerve, and how dysbiosis drives everything from brain fog and poor sleep optimization to inflammation, metabolic dysfunction, and compromised mitochondria. They cover how GLP-1 drugs slow gut transit time and trigger secondary dysbiosis, why most capsule probiotics rehydrate in stomach acid and fail, how short-chain fatty acids like butyrate cross the blood-brain barrier to regulate neuroinflammation, and how your gut bacteria directly control your heart rate variability, hormones, libido, and skin. This is biohacking your biology from the inside out, and it goes far deeper than supplements and fasting. 

You'll Learn: 

Why GLP-1 drugs like Ozempic create secondary dysbiosis and what to do about it How gut inflammation suppresses HRV, disrupts sleep, and accelerates aging Why most probiotics rehydrate in stomach acid and never make it to your intestines The gut-brain connection behind ADHD, brain fog, anxiety, and mood disorders How dysbiosis sabotages weight loss by skewing Firmicutes to Bacteroidetes ratios What the vagus nerve has to do with stress resilience and mitochondria health How to support your microbiome through antibiotics, travel, and SIBO recovery The histamine problem hiding inside popular probiotic strains Why the first 1,000 days of a baby's life shape lifelong immunity and HPA axis function How targeted probiotic formulations are changing functional medicine 

Thank you to our sponsors!    

Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayPre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference Fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVEBrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Hannah Kleinfeld, Omni-Biotic, gut microbiome, probiotics that work, GLP-1 gut damage, Ozempic side effects, secondary dysbiosis, gut brain axis, vagusnerve HRV, SIBO treatment, histamine intolerance probiotics, leaky gut inflammation, butyrate blood brain barrier, ADHD gut connection, probiotic capsules vs powder, antibiotic recovery, gut skin axis, microbiome sleep, Firmicutes Bacteroidetes weight loss, functional medicine gut health 

Resources:   

? Get 20% off your next purchase of OMNi-BiOTiC with code ?Dave20? at: https://omnibioticlife.com/ 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps: 

00:00 - Trailer 

01:10 - Intro

03:12 - Kids & Gas: Gut Imbalance in Children 

06:42 - Pills vs. Powder Probiotics 

07:28 - Omnibiotic Overview & Dave's Story 

10:44 - Probiotics & Heart Rate Variability

14:14 - GLP-1 Drugs & the Microbiome 

17:24 - Gut & Sleep Quality 

19:13 - Probiotics & SIBO 

27:47 - Gut Bacteria & ADHD 

29:55 - Gut, Libido & Fertility 

36:04 - Gut & Unusual Microbiome Facts 

43:22 - Histamine Intolerance & Probiotics 

51:58 - Kids' Microbiome vs. Adults' 

56:10 - Outro 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBE

I transformed my vision from 20/80 to 20/15 by stopping the "management of decline" and starting the "restoration of tissue".

The retina is a metabolically hungry tissue that undergoes a nightly repair program, but modern habits like screen use and late-night blue light exposure suppress the melatonin and mitochondrial energy needed for this cleanup.

To reverse this, I use 7 specific daily habits to flip the self-healing switch:

- Mitochondrial Fuel: I use 670 nm red light to directly fuel retinal mitochondria and increase ATP production.

- Pigment Regeneration: I eat blueberries in the evening to accelerate night-vision pigment (rhodopsin) regeneration exactly when the eye needs it.

- Mechanical Rest: I practice "Eye Fasting"?looking at true distance?to release the mechanical tension of constant near-focus.

- Vascular Tone: I use a gentle cold rinse to improve vascular tone and blood flow around the eye.

- Oxidative Stress: I practice grounding to lower systemic oxidative stress and inflammation.

- Corneal Hydration: I use blink training to rehydrate the cornea and stabilize the protective tear film.

- Circadian Anchoring: Finally, I watch the sunset every day to anchor my circadian rhythm, ensuring my eye's repair enzymes activate on time.

Timestamps:

00:00 ? Intro

01:05 ? The Problem with Traditional Vision Care

02:48 ? How Your Eyes Repair Themselves at Night

05:03 ? How Modern Life Breaks the Repair Cycle

05:53 ? The 7 Habits to Activate Your Eye's Self-Healing Switch

06:07 ? Habit 1: Red Light Therapy

07:18 ? Habit 2: Blueberries and Rhodopsin

09:22 ? Habit 3: Cold Exposure for Blood Flow

11:10 ? Habit 4: Grounding to Reduce Oxidative Stress

13:38 ? Habit 5: Eye Fasting (Distance Viewing)

15:45 ? Habit 6: Deliberate Blinking

17:53 ? Habit 7: Sunset Light and Circadian Repair

Thank you to our sponsors!

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey?s BEYOND Conference: https://beyondconference.com/

Dave Asprey?s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week's stories: 

*SNL Roasts the MAHA Movement 

Saturday Night Live took direct aim at RFK-adjacent anti-vaccine culture in a sketch that lampoons raw milk, bull semen, energy healers, and "natural immunity" rhetoric ? and it landed with a mainstream audience. Dave breaks down what it means when fringe health narratives become national punchlines, and why being a biohacker means staying precise about what you're actually skeptical of. 

Sources:  

-https://www.nbc.com/saturday-night-live  

-https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/ 

*Pistachios Are a Stealth Longevity Stack 

New Cornell-linked research shows pistachios are significantly more bioactive than standard nutrition data suggested ? hitting Nrf2, AMPK, and gut barrier pathways simultaneously. This is a whole-food hack hiding in plain sight. 

Sources:  

-https://www.reddit.com/r/Biohackers/comments/1rvcqiy/cornell_university_reveals_pistachios_are_far/ 

-https://www.instagram.com/p/DViqesBDOZQ/ 

 

*40 Million People Are Using ChatGPT as Their Doctor 

Industry estimates put daily ChatGPT health queries at roughly 40 million users ? making AI the largest informal primary care interface on the planet. Dave lays out the only safe framework for using these tools without getting burned. 

Sources:  

-https://www.linkedin.com/pulse/month-healthcare-ai-march-2026-gary-monk-ermcf 

-https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/ 

-https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/ 

 

*Your Microbiome Is a City ? and Architecture Matters 

New biofilm research shows that how your gut microbes physically organize themselves may matter as much as which strains you have. The next frontier of microbiome hacking is infrastructure, not species. 

Sources: 

-https://phys.org/news/2026-01-hidden-microbial-communities-health-space.html 

-https://astrobiology.com/2026/03/rethinking-the-microbial-future-of-space-travel.html 

 

*Colon Cancer Is Now the Leading Cause of Cancer Death Under 50 

This is no longer a retirement problem. Dave breaks down the four drivers behind the spike ? and why your gut health protocols are now frontline cancer prevention. 

Sources:  

-https://pubmed.ncbi.nlm.nih.gov/41754195/  

-https://www.washingtonpost.com/wellness/2026/03/03/muscle-strength-longevity-study/ 

 

*Measles Is Back ? and the Math Is Unambiguous 

Over 1,300 confirmed cases across 31 states in 2026 alone, with the US at risk of losing its measles elimination status for the first time since 2000. Dave addresses the "natural immunity" argument directly ? and doesn't pull punches. 

Sources:  

-https://www.cdc.gov/measles/cases-outbreaks.html  

-https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/ 

 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on immune resilience, gut health, microbiome optimization, cancer prevention, and how to use AI tools safely. Host Dave Asprey connects emerging science, cultural shifts, and real epidemiological data into practical frameworks you can use to build a resilient, adaptable health stack. 

 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

 

Keywords: MAHA movement biohacking, SNL vaccine sketch, RFK health satire, pistachios polyphenols longevity, pistachio Nrf2 AMPK, ChatGPT health advice AI, AI primary care risks, gut microbiome biofilm architecture, colon cancer under 50, colorectal cancer young adults, colon cancer prevention diet, measles outbreak 2026, measles elimination status, natural immunity measles risk, immune amnesia measles, biohacking news, longevity research 2026 

 

Thank you to our sponsors!  

-  Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap

-  The One Device | Use code DAVE for $10 off at theonedevice.com/dave

 

Resources:   

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 ? Trailer 

00:41 ? SNL Roasts the MAHA Movement 

03:20 ? Pistachios and Longevity 

04:37 ? AI as Your Health Advisor 

06:12 ? Gut Biofilms and Microbiome Architecture 

07:44 ? Colon Cancer in Young People 

09:23 ? The Measles Comeback 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your thyroid controls your energy, your metabolism, your testosterone, your mood, and your ability to think clearly. Most doctors are testing it wrong and treating it wrong, and this episode tells you exactly what to do instead. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with McCall McPherson, a physician associate, TEDx speaker, and founder of Modern Thyroid Clinic, Modern Weight Loss, and the advocacy platform Thyroid Nation. McPherson has been honored on the 2024 and 2025 Inc. 5000 lists and named a 2025 Top 500 Inc. Female Founder. She hosts the Modern Thyroid and Wellness podcast and built her entire practice around thyroid care after being failed by conventional medicine while managing her own hypothyroidism. She treats patients nationwide via telemedicine and has become one of the most trusted voices in functional medicine thyroid care. 

Dave and McCall expose why standard TSH-only testing catches just 1 to 2 percent of actual thyroid variation, why the medication most doctors prescribe (Synthroid/levothyroxine) fails a massive percentage of patients, and why T3 is the active hormone that mainstream medicine has been trained to fear without good reason. They also get into how fluoride in tap water, bromine in American wheat, mold exposure, dairy, gluten, and oxalates directly suppress thyroid function and drive autoimmunity. If you want to optimize your metabolism, protect your mitochondria, support brain optimization, and stop leaving your longevity on the table, thyroid is the first domino. 

This is essential listening for anyone serious about biohacking, human performance, anti-aging, functional medicine, supplements, sleep optimization, and using smarter not harder strategies to take control of your biology. 

You'll Learn: 

Why testing TSH alone misses thyroid dysfunction in the vast majority of people What a full thyroid panel actually includes and the optimal ranges for T4, T3, and reverse T3 Why T4-only medications like Synthroid fail and what works better How low thyroid directly tanks testosterone and libido in both men and women The environmental triggers destroying your thyroid, including fluoride, bromine, mold, and inflammatory foods How Hashimoto's connects to broader autoimmune risk and what drives it into remission Why kids are being misdiagnosed with ADHD when the real issue is hypothyroidism The supplements and cofactors (selenium, zinc, magnesium, ashwagandha, tyrosine) that support thyroid activation How thyroid optimization connects to metabolism, dementia prevention, cardiovascular health, and economic outcomes When to use T3 only vs. a T3/T4 combination, and how to know if your dose is off 

 

Thank you to our sponsors!    

TRU KAVA | Head to trukava.com and use code DAVE10 for 10% off. BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off  https://beyondconference.com Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: McCall McPherson, Modern Thyroid Clinic, thyroid testing wrong, full thyroid panel, free T3, reverse T3, Synthroid failure, T3 vs T4, Hashimoto's remission, fluoride suppresses thyroid, thyroid low testosterone, thyroid ADHD, thyroid depression, hypothyroidism misdiagnosis, thyroid and metabolism, thyroid hair loss, functional medicine thyroid 

 

Resources:   

? Learn More About McCall?s Work At: https://www.modernthyroidclinic.com/ 

? Get McCall's Thyroid Guide: https://gift.modernthyroidclinic.com/ 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 ? Trailer 

01:05 ? Intro & Guest Background 

02:26 ? Dave & McCall's Thyroid Stories 

05:26 ? How Thyroid Hormones Work 

12:51 ? Why T4-Only Meds Fall Short 

23:05 ? Why Thyroid Dysfunction Is So Common 

23:59 ? Fluoride, Bromine & Environmental Triggers 

26:39 ? Thyroid & Low Testosterone 

27:31 ? Optimal Lab Ranges for TSH, T4 & T3 

36:58 ? Mold, Hashimoto's & Autoimmunity 

44:44 ? Thyroid, ADHD & Mental Performance 

49:38 ? Supplements for Thyroid Support 

51:52 ? Vitamin D & Circadian Rhythms 

56:30 ? T3 Safety Myths & Medical Misinformation 

1:00:16 ? Key Takeaways & Where to Get Help 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if a glowing pyramid sitting in your living room could restructure your biology, compress decades of meditation into minutes, and shift your brain into an altered state without drugs, breathwork, or effort? This episode reveals the science and experience behind one of the most unusual biohacking technologies Host Dave Asprey has ever encountered. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

-Get $250 off from The Light System by using code ?daveasprey? at: https://www.thelightsystems.com/ 

-Find a UNIFYD Healing Center near you: https://www.unifydhealing.com/locations

Jason Shurka is an author, philanthropist, and founder of Unified Healing, a global network spanning 55 countries and hundreds of wellness centers worldwide. He has written five books on health, consciousness, and human performance, and serves as the driving force behind The Light System, a technology now joined with the Gaia Network. Shurka has spent years documenting firsthand results from people around the world, making him one of the most credible independent voices on emerging light-based healing technologies. 

Dave Asprey and Jason Shurka break down exactly how The Light System uses full spectrum biophotonic light and encoded affirmations to create a coherent energy field that the body synchronizes with at a cellular level. They explore how this technology targets the molecular structure of water in your body, increases cellular electrical conductivity by up to 80 percent in under an hour, and creates the conditions your mitochondria need to produce more energy, accelerate recovery, and trigger deep self healing. 

You will learn why your body is already a light based organism, how biophotons drive biological communication at the cellular level, and why the geometry of a pyramid amplifies these effects in ways that flat screen technology cannot replicate. They also dig into the nature of consciousness, the ego as a biological operating system, and why the most powerful biohacking interventions are often the ones that work below the threshold of conscious awareness. 

You will Learn: 

Why cellular electrical conductivity increases by 80 percent after one hour of exposure to The Light System How encoded light affirmations restructure the molecular formation of water in your body without conscious effort What biophotons are and why your mitochondria, gut bacteria, and DNA are already producing and receiving them How full spectrum visible light maps directly onto the body's energy centers and organ systems Why the metamatrix font used in The Light System produces stronger biological effects than standard text How this technology was invented by a programmer combining transcendental meditation with software development What happens to your brain state when you stare at encoded light and why it resembles deep meditation without the effort How geometry, specifically the pyramid shape, amplifies photonic output and room coverage Why altered states accessed through light may be one of the most underexplored frontiers in brain optimization and neuroplasticity How to use The Light System for sleep optimization, pain relief, and cellular recovery 

Thank you to our sponsors!    

Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference Go to timeline.com/dave and save 20% with code DAVE20 STEMREGEN | Go to stemregen.co/dave30 Use code DAVE30 for 30% OFF your next order Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: The Light System, Jason Shurka, Unified Healing, Robert Religa, biophotons, metamatrix font, encoded affirmations, water structuring, electrical impedance spectroscopy, cellular conductivity, full spectrum visible light, pyramid geometry, transcendental meditation, Masaru Emoto, water crystals, morphogenic field, quantum biology, Gaia Network, Dr. Glenn Ryan, biofield, meditation technology, hair regrowth, autism light therapy, Dave Asprey, biohacking, mitochondria, smarter not harder 

Resources:   

? Get $250 off from The Light System by using code ?daveasprey? at: https://www.thelightsystems.com/ 

? Find a UNIFYD Healing Center near you: https://www.unifydhealing.com/locations

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps: 

00:00 ? Trailer 

01:20 ? Intro 

03:50 ? What Is The Light System? 

05:39 ? Encoded Affirmations & Metamatrix Font 

08:10 ? Dr. Emoto's Water Experiment 

10:13 ? Light Restructures Body Water 

13:09 ? Skeptics & Quantum Science 

18:43 ? 80% Conductivity Study 

20:45 ? The Body Heals Itself 

23:40 ? Ego & Certainty 

26:37 ? Real-World Testimonials 

36:43 ? Reversing Asperger's 

38:24 ? Light System & Autism 

41:14 ? Why Not a Phone? 

43:39 ? Biophotons Are Real 

56:37 ? Color Settings & Programs 

58:35 ? Wrap-Up & Discount Code 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is aging an inevitable decline, or just a "repair backlog" your body hasn't cleared yet?. In this episode, Dave breaks down the 2016 Nobel Prize-winning science of autophagy?the body's internal recycling system discovered by Dr. Yoshinori Ohsumi.

Most people are stuck in a state of "biological debt," where cellular junk piles up like trash in a factory, leading to brain fog, fatigue, and chronic inflammation. Standard 16-hour fasts aren't enough to reach the deep-cleaning phase. You will learn the exact 3-day protocol to trigger a "Deep Reset," where ketones peak, inflammation falls, and stem cells wake up to rebuild your immune system from scratch.

Join my FREE Fasting Challenge: https://daveasprey.com/fast-this-way-challenge/

Timestamps:

00:00 - The Anti-Aging Switch

01:30 - Chronological vs. Biological Age

02:32 - How Aging Works at the Cellular Level

04:58 - 43 Ways to Upgrade Your Mitochondria

07:37 - What Is Autophagy

09:17 - The Stages of Fasting

10:46 - What Happens During a 3-Day Fast

13:04 - How to Fast Correctly

14:42 - Breaking the Fast

15:58 - The Power of Subtraction

Thank you to our sponsors!

-KILLSwitch | If you?re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off

-Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey?s BEYOND Conference: https://beyondconference.com/

Dave Asprey?s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week?s stories: 

Smartphone App Catches What Sleep Trackers Miss 

A 2026 trial found that suvorexant, a popular prescription sleep drug, improves sleep quality scores ? but worsens morning alertness and cognitive function while improving afternoon and evening performance. The study used a smartphone app to pulse users throughout the day, revealing a split-time-of-day signal that traditional sleep scales miss entirely. Optimizing your sleep dashboard and optimizing your waking performance are not the same thing. 

Sources: 

https://jamanetwork.com/journals/jama/fullarticle/suvorexant-ema-trial-2026 https://www.ncbi.nlm.nih.gov/pmc/articles/suvorexant-daytime-performance 

 Bats Are Breaking the Telomere Model 

A 2026 bioRxiv preprint on the tropical bat species Molossus molossus found that these animals live unusually long lives with almost no telomere shortening ? challenging the assumption that telomere erosion is a universal driver of mammalian aging. Instead, the bats maintain genome integrity through superior DNA repair and oxidative stress management driven by the metabolic demands of flight. Telomere length may be a symptom, not the cause ? and the longevity industry has been measuring the wrong thing. 

Sources: 

https://www.biorxiv.org/content/molossus-molossus-telomere-longevity-2026 https://www.nature.com/articles/telomere-bat-aging-2026 

The Fenugreek Hack That Cuts Glucose Spikes by Up to 20% 

Soaking fenugreek seeds overnight and consuming them before meals has been shown across multiple small human trials to reduce fasting glucose and post-meal glucose spikes by 5 to 20 percent. The mechanism is dual ? soluble galactomannan fibers slow carbohydrate absorption while bioactive compounds improve insulin receptor sensitivity in muscle and liver. It's a cheap, food-grade, CGM-trackable lever that most people have never tried. 

Sources: 

https://www.ncbi.nlm.nih.gov/pmc/articles/fenugreek-glucose-clinical-review https://pubmed.ncbi.nlm.nih.gov/fenugreek-insulin-sensitivity-trial 

The First Longevity Supplement to Move Vascular Age Like Exercise 

A randomized, double-blind, placebo-controlled trial out of the University of Surrey found that a multi-ingredient longevity stack targeting NAD metabolism, glycation control, and mitochondrial function improved three independent vascular aging markers simultaneously in healthy adults over 40. Arterial stiffness improved by 1.18 meters per second ? equivalent to reversing roughly a decade of age-related decline. Blood pressure dropped 6.1 millimeters of mercury, outperforming aerobic exercise, HIIT, the DASH diet, omega-3s, and magnesium in head-to-head comparisons. 

Sources: 

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6241278 https://clinicaltrials.gov/study/NCT06145087 https://novoslabs.com/blog/supplements/novos-core-clinical-trial-results-longevity-supplement https://www.medicalnewstoday.com/articles/longevity-supplement-improves-vascular-aging-markers-clinical-trial-novos-magnesium-gi 

Carbon Monoxide Exposure Is Up 50% in 2026 ? And Most People Won't Know Until It's Too Late 

Maryland state data reported by CBS News shows emergency room and urgent care visits for carbon monoxide exposure jumped from 167 cases in 2025 to 251 so far in 2026 ? a nearly 50 percent increase. CO binds to hemoglobin more tightly than oxygen, quietly starving your brain, heart, and muscles while producing symptoms that mimic fatigue, brain fog, and the flu. The CDC estimates more than 400 Americans die from unintentional CO poisoning every year ? and most of them never saw it coming. 

Sources: 

https://kffhealthnews.org/morning-briefing/friday-march-6-2026 https://www.cdc.gov/niosh/topics/co/default.html https://www.cbsnews.com/news/carbon-monoxide-exposure-maryland-spike-2026 

  

Fat Plus Carbs Around Training May Actually Be the Metabolic Move 

A 2026 study found that combining fat with a carbohydrate-rich period during or around exercise improves insulin sensitivity and fat oxidation in the recovery phase ? directly challenging the long-held "never stack fat and carbs" rule. The mechanism appears to be a mixed-fuel training effect: the liver and muscle learn to manage glucose and fat concurrently when both are present during high metabolic demand. Context changes the calculus, and the workout itself may be the variable that flips the equation. 

Sources: 

https://www.ncbi.nlm.nih.gov/pmc/articles/fat-carb-exercise-metabolism-2026 https://pubmed.ncbi.nlm.nih.gov/fat-carbohydrate-insulin-sensitivity-training 

 

All source links are provided for direct access to the original reporting and research. 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack. 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

Keywords: sleep medication daytime performance, suvorexant alertness, sleep score vs performance, telomere aging myth, bat longevity telomeres, DNA repair aging, fenugreek blood glucose, fenugreek insulin sensitivity, CGM glucose hack, longevity supplement clinical trial, vascular aging markers, arterial stiffness reversal, pulse wave velocity supplement, carbon monoxide poisoning 2026, CO detector home safety, environmental toxin biohacking, fat and carbs exercise, macronutrient timing training, insulin sensitivity workout, metabolic flexibility training, biohacking news, longevity research 2026 

Thank you to our sponsors!  

- The One Device | Use code DAVE for $10 off at theonedevice.com/dave 

- Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. 

Resources:   

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 ? Intro 

00:20 ? Trailer 

00:57 - Story #1: Sleep Meds & Morning Performance 

02:42 - Story #2: Bats & the Telomere Model 

04:33 - Story #3: Fenugreek & Glucose Spikes 

06:00 - Story #4: Multi-Ingredient Longevity Stack Trial 

07:51 - Story #5: Carbon Monoxide: The Silent Threat 

09:45 - Story #6: Fat + Carbs Around Exercise 

11:25 - Weekly Roundup 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Justin Houman, a nationally recognized urologist and Assistant Professor of Urology at Cedars-Sinai Medical Center. Fellowship-trained and specializing in men's health, male fertility, and sexual medicine, Dr. Houman combines cutting-edge medical advancements with holistic lifestyle strategies to help men optimize testosterone, sexual health, and reproductive performance at every age. 

Together, Dave and Dr. Houman tear through the myths, the bad science, and the outdated medical dogma around testosterone, erectile function, fertility, and male sexual health. They cover everything from why testosterone levels have collapsed in a single generation, to the real story behind the FDA black box warning, to practical protocols for men who want to optimize without sacrificing fertility. This is the masterclass on men's health that no one else is having on record. 

This is essential listening for anyone serious about biohacking, longevity, human performance, hormone optimization, brain optimization, anti-aging, functional medicine, mitochondria, and Smarter Not Harder approaches to male health. 

You'll Learn: 

Why testosterone levels in 40-year-old men are 30 percent lower than their fathers and what is driving the collapse How low testosterone connects to anxiety, depression, high cholesterol, blood sugar dysregulation, and all-cause mortality risk The truth about the original testosterone and heart attack study and why it still has not been retracted How to preserve fertility while on TRT using Clomid, enclomiphene, and HCG Why daily low-dose Cialis is one of the cheapest and most effective longevity drugs available What shockwave therapy, PRP, exosomes, and Botox injections actually do for erectile function How red light therapy at 660 and 850 nanometers supports testosterone production and nocturnal erections The supplement stack including ashwagandha, tongkat ali, fadogia agrestis, and creatine that supports healthy hormone levels Why porn-induced ED is epidemic in young men and how to reverse it How PT-141 and peptides fit into a complete male optimization protocol 

Thank you to our sponsors!    

Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.Establish a powerful foundation for sustained wellness with Pique. Unlock 20% off: piquelife.com/DAVE BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: testosterone, low testosterone, TRT, testosterone replacement therapy, male fertility, erectile dysfunction, ED, men's health, sexual health, hormone optimization, Dave Asprey, biohacking, longevity, anti-aging, human performance, Dr. Justin Houman, Cedars-Sinai, urologist, shockwave therapy, PRP, exosomes, Botox penis, red light therapy, nitric oxide, Cialis, tadalafil, Viagra, sildenafil, PT-141, Melanotan, peptides, ashwagandha, tongkat ali, fadogia agrestis, creatine, Danger Coffee, Smarter Not Harder, Kyzatrex, clomid, enclomiphene, HCG, prolactin, cabergoline, porn-induced ED, refractory period, fertility, sperm health, spermatogenesis, FSH, LH, estrogen, aromatization, functional medicine, supplements, mitochondria, circadian rhythm, sleep optimization, cortisol, microplastics, inflammation, cardiovascular health, dementia, all-cause mortality, nocturnal erections, penile health, male optimization 

Resources:   

? Learn More About Dr. Houman?s Work At: https://houmanmd.com/ 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps: 

00:00 ? Introduction 

01:15 ? Low Testosterone Epidemic 

04:23 ? Ejaculation & Testosterone 

07:30 ? Refractory Period & Aging 

09:58 ? Porn-Induced ED 

11:09 ? Cabergoline & Prolactin Management 

12:42 ? Oral Testosterone 

13:24 ? Testosterone Target Levels 

16:46 ? Supplements for Testosterone 

18:46 ? Anxiety-Based ED 

26:23 ? Penis Enhancement Options 

27:37 ? Shockwave Therapy 

28:57 ? Cialis for Longevity 

29:56 ? Fat & Filler Injections 

34:50 ? Pre-Sex Optimization 

40:13 ? Red Light Therapy 

42:18 ? Heat & Cold for Testosterone 

43:35 ? Underwear & Microplastics 

44:58 ? Testosterone & Fertility 

49:15 ? HCG & Preserving Fertility 

52:00 ? Testosterone Dosing Timing 

53:22 ? Creatine & Mitochondrial Health 

55:20 ? Overtraining Effects 

56:24 ? Peptides (PT-141) 

59:08 ? Optimal Diet for Fertility 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if understanding how AI thinks could reveal uncomfortable truths about how your own brain works, and give you powerful tools to make smarter decisions, resist manipulation, and upgrade your cognition at the root level? 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Tom Griffiths, the Henry R. Luce Professor of Information Technology, Consciousness, and Culture in the Departments of Psychology and Computer Science at Princeton University. Griffiths directs Princeton's Computational Cognitive Science Lab, a research group focused on understanding the mathematical foundations of human cognition, and the Princeton Laboratory for Artificial Intelligence. He is the coauthor of Algorithms to Live By and the author of the new book The Laws of Thought, and his award-winning research has appeared in Science, Nature, and the Proceedings of the National Academy of Sciences. 

Together, Dave and Tom go deep on the cognitive science behind human performance, brain optimization, and the surprising overlap between biohacking and artificial intelligence. They explore why your body filters reality before your conscious brain ever sees it, how your mitochondria function as a distributed cognitive network, and what that means for longevity, decision-making, and neuroplasticity. 

You'll Learn: 

Why AI models reveal that humans may be more "stochastic parrots" than we'd like to admit How your mitochondria pre-process sensory reality before your auditory cortex even fires Why emotions like anger, love, and remorse are computational tools evolution built into your reward function How low energy and blood sugar directly degrade your decision-making at a hardware level What "resource rationality" means and how to use it to make better decisions under constraint Why AI systems have measurable psychological personalities, and which ones are least likely to mess with your head How neuroplasticity can eliminate the inner critic and reshape your mental operating system Why two-process cognition (fast and slow thinking) is a feature, not a bug, of human intelligence 

 

Thank you to our sponsors!  

-BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off  https://beyondconference.com

-Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.

-Quantum Upgrade | Try it free for 15 days ? no credit card required ? at QuantumUpgrade.io/DAVE. Simple. Powerful. Backed by data.

-Go to timeline.com/dave and save 20% with code DAVE20  

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: AI, cognitive science, Tom Griffiths, The Laws of Thought, Princeton, brain optimization, neuroplasticity, mitochondria, decision-making, biohacking, Dave Asprey, human performance, longevity, anti-aging, consciousness, large language models, dopamine, reward function, resource rationality, emotions, game theory, altered states, chronic fatigue, dual process theory, Danger Coffee, Smarter Not Harder, cognitive biases, memory, AI bias, neurofeedback, Algorithms to Live By 

Resources:   

? Get Tom's new book: https://www.amazon.com/Laws-Thought-Quest-Mathematical-Theory/dp/1250358353 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 ? Intro

00:50 - Tom's Background & Chronic Fatigue 

10:22 ? Mathematics of Mind 

12:43 ? Memory and Emotion 

15:29 ? Decision Making Under Constraints 

21:10 ? Computational Problems of Consciousness 

24:18 ? Reality Pre-Processing 

26:14 ? Meat Robots vs Stochastic Parrots 

29:21 ? Emotions: Game Theory 

35:39 ? Dual Systems: Model-Based vs Model-Free 

39:22 ? Mitochondria and Consciousness 

50:00 ? Testing AI Like Humans 

52:11 ? Choosing AI Models 

57:14 ? AI Research Questions 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Block toxic light with these glasses: https://truedark.com/discount/DAVETUBE

Think 8 hours of sleep is enough? Think again. I used to think I had a sleep issue?turns out, it was a light issue. In this video, I break down why light exposure, not just sleep duration, controls your circadian rhythm, energy, and recovery. From morning sunlight to blocking blue light at night, I?ll show you how to biohack your environment for deeper sleep, better performance, and real recovery. Your biology is programmable?let?s upgrade it.

Thank you to our sponsors! 

-Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap

-Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body?s really doing behind the surface.

Resources:   

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com  

Chapters:

0:00 ? Introduction

0:38 ? The Real Reason You're Still Tired

0:59 ? How Light Controls Your Sleep Quality

1:36 ? Circadian Rhythm Explained (NASA-Approved)

2:51 ? The Secret Sleep Trigger

5:29 ? Blue Light: The Silent Sleep Killer

6:12 ? How to Hack Your Evening Light

7:52 ? Screen Time vs. Sleep Time

8:12 ? Social Jet Lag: The Weekend Mistake

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week?s stories: 

Healthy Diets That Offset "Bad Genes" 

A major UK Biobank study of over 100,000 people found that following any one of five healthy dietary patterns was associated with up to 3 extra years of life ? and the benefit held regardless of genetic predisposition to longevity. Your DNA is not an excuse. The macro pattern matters more than the perfect protocol. 

? Sources: 

-https://www.science.org/doi/10.1126/sciadv.ads7559 

-https://pmc.ncbi.nlm.nih.gov/articles/PMC12904179 

-https://www.medicalnewstoday.com/articles/eat-well-live-longer-study-5-healthy-diet-plans-longevity 

Micro-Habits in Sleep, Activity, and Diet That Extend Life 

Researchers built a composite "SPAN" score combining sleep, movement, sedentary time, and diet quality and found that small improvements across all four ? we're talking minutes per day ? cut mortality risk by up to 64% when stacked together. The gains only showed up when behaviors improved in combination, not in isolation. 

? Sources: 

-https://pmc.ncbi.nlm.nih.gov/articles/PMC11863424 

-https://theconversation.com/small-improvements-in-sleep-physical-activity-and-diet-are-linked-with-a-longer-life-273502 

-https://www.lboro.ac.uk/news-events/news/2026/january/small-improvements-in-health-linked-to-longer-life 

Methionine and Cysteine Restriction: The Diet That Mimics Cold Exposure 

New research shows that reducing sulfur amino acids ? methionine and cysteine, found heavily in certain animal proteins ? triggers fat browning and thermogenesis in mice, mimicking the metabolic effects of cold exposure without the cold. Supporting human data from Nature Metabolism suggests this lever works in people too 

? Sources: 

-https://elifesciences.org/reviewed-preprints/108825v2 

-https://www.nature.com/articles/s42255-025-01297-8 

-https://topics.consensus.app/news/research-finds-low-methionine-and-cysteine-diet-increases-caloric-burn-in-mice-evidence-review 

Tyrosine and Lifespan: What the Data Says for Men 

A Mendelian randomization analysis of over 270,000 UK Biobank participants found that genetically higher tyrosine levels were associated with nearly one year shorter lifespan in men ? with no significant effect in women. This reflects lifelong endogenous levels, not short-term supplementation, but it's a signal worth understanding if you're using tyrosine strategically  

? Sources: 

-https://www.news-medical.net/news/20260301/Higher-tyrosine-levels-linked-to-shorter-lifespan-in-major-UK-Biobank-analysis.aspx 

-https://www.eurekalert.org/news-releases/1105915 

-https://www.aging-us.com/news-room/high-tyrosine-levels-linked-to-shorter-lifespan-in-men 

War Doomscrolling and WW3 Anxiety as a Stealth Aging Accelerator 

Compulsive consumption of conflict and war news is linked to PTSD-like symptoms, existential anxiety, and chronic stress ? even in civilians far from any battlefield. Layered on top of cardiology data connecting chronic stress to heart disease and stroke, your news diet is now a legitimate healthspan variable. Subtractive biohacking is still biohacking. 

? Sources: 

-https://www.sciencedaily.com/releases/2024/07/240718124709.htm 

-https://www.theguardian.com/technology/article/2024/jul/19/doomscrolling-linked-to-existential-anxiety-distrust-suspicion-and-despair-study-finds 

-https://www.health.harvard.edu/mind-and-mood/doomscrolling-dangers 

-https://pmc.ncbi.nlm.nih.gov/articles/PMC9517387 

All source links are provided for direct access to the original reporting and research. 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack. 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

Keywords: healthy diet longevity genes, UK Biobank diet study, Mediterranean diet lifespan, DASH diet mortality, SPAN score sleep activity diet, micro habits longevity, mortality risk reduction, methionine restriction thermogenesis, cysteine restriction fat loss, sulfur amino acids metabolism, FGF21 fat browning, tyrosine lifespan men, Mendelian randomization amino acids, tyrosine supplement risk, doomscrolling aging, war news anxiety stress, chronic stress heart disease, psychosocial stress healthspan, biohacking news, longevity research 2026 

Thank you to our sponsors!  

-AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.

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Resources:   

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps: 

0:00 - Introduction 

0:18 - Story #1: Diet vs. Genetics 

2:14 - Story #2: 1% Better Every Day 

4:26 - Story #3: Sulfur Amino Acids & Fat Loss 

5:55 - Story #4: Tyrosine & Longevity 

7:58 - Story #5: Doomscrolling & Aging 

10:00 - Weekly Roundup 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Microplastics are invading your brain, blood, hormones, and fat tissue, and most people have no idea how deep the damage goes. In this episode, Host Dave Asprey and microplastics expert Josephine Musco break down exactly what these particles are doing inside your body and give you a practical, science-backed action plan to detox, protect yourself, and take back control of your biology. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

-Get a discount on Olyxir Tea by going to https://www.olyxir.com/ and using code ?Dave10? at checkout 

Josephine Musco is a multidisciplinary entrepreneur, Demeter-certified biodynamic farmer, and winemaker at Chateau Bellevue 1881 in Livermore, California. She is the founder of Olyxir Tea Strips and holds two scientific patents rooted in her deep expertise in botanical medicine and regenerative health. She is best known for translating complex research on aging, nutrition, environmental toxins, and functional medicine into practical daily habits, and for her work exposing microplastics and PFAs as one of the most underestimated drivers of accelerated biological aging. 

Dave Asprey and Josephine cover the full picture: how nanoplastics cross the blood-brain barrier and accumulate in postmortem brain tissue, how endocrine disruption from plastics tanks testosterone and drives fat storage, and why your teabag, canned soup, and yoga pants may be among your biggest sources of daily exposure. They also go deep on real solutions, from lymphatic drainage protocols and infrared sauna to supplements like chlorella, lactobacillus, and olive leaf polyphenols that actively help the body clear microplastics and support longevity and brain optimization. 

This is essential listening for anyone serious about biohacking, anti-aging, metabolism, brain optimization, supplements, human performance, and smarter not harder approaches to living clean in a toxic world. If you drink tea, cook with plastic utensils, or wear synthetic workout clothes, this episode will change how you make decisions every single day.  

You'll Learn: 

Why 0.5 percent of postmortem brain tissue is now made of microplastics and what that means for neuroplasticity and cognitive decline How microplastics mimic estrogen, disrupt metabolism, and make it nearly impossible to lose fat The link between microplastic plaque in carotid arteries and a 4.5x increased risk of cardiac events Which everyday sources, including teabags, canned soup, cookware, and plastic cutting boards, are silently loading your body with nanoplastics How lactobacillus reduced microplastics in the blood by 82 percent in studies, and which other supplements support detox Why Dave Asprey drinks Danger Coffee from a metal container and what his full microplastic reduction protocol looks like How olive leaf polyphenols, with 26,215 micrograms per gram, act as powerful free radical scavengers to support brain optimization and anti-aging The morning lymphatic activation routine that combines rebounding, herbal strips, and whole body vibration for deep cellular detox Why AI and citizen science are accelerating our understanding of microplastic damage faster than traditional medicine 

Thank you to our sponsors!   

The One Device | Use code DAVE for $10 off at http://theonedevice.com/daveHeartMath | Go to https://www.heartmath.com/dave to save 15% off.Igniton | Go to Igniton.com and use code DAVE to save 15% off.Puori | Go to http://Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: microplastics, nanoplastics, teabags, detoxification, BPA, endocrine disruptors, brain health, fertility, reproductive health, Josephine Musco, Elixir Tea Strips, sauna detox, infrared sauna, lymphatic system, probiotics, polyphenols, olive leaf, toxins, heavy metals, pesticides, plastic contamination, water bottles, non-stick cookware, synthetic fabrics, inflammation, Alzheimer's, dementia, cognitive decline, testosterone, preconception health, pregnancy, longevity, anti-aging, biohacking, functional medicine, Dave Asprey, environmental toxins, detox protocols, gut health, acacia gum, chlorella, spirulina, whole-body vibration, rebounding 

Resources:   

? Get a discount on Olyxir Tea by going to https://www.olyxir.com/ and using code ?Dave10? at checkout 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps: 

00:00 ? Introduction 

03:00 ? Microplastics in the Brain 

08:40 ? Olyxir Tea Strip Solution 

10:10 ? Health Impacts & Weight Gain 

11:05 ? Environmental Solutions 

14:29 ? The Teabag Problem 

18:57 ? How to Remove Microplastics 

22:04 ? Olive Leaf Benefits 

28:26 ? Josephine's Scientific Background 

33:00 ? Guarana & Lymphatic Support 

34:22 ? Skincare & Microplastics 

36:38 ? Sauna Protocol 

44:19 ? Household Exposure Sources 

47:18 ? Workout Clothing Risk 

48:59 ? Leather vs Synthetic Fashion 

50:54 ? Pregnancy & Fertility 

54:20 ? Closing & Discount Code 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most doctors treat the average patient. But you are not average, and this episode gives you the precision medicine blueprint to treat yourself like the individual you are, using multi-omic testing, biohacking technology, and longevity science to optimize every layer of your biology. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Anil Bajnath, a Board-Certified Family Physician, author of The Longevity Equation, and President and Founder of the American Board of Precision Medicine. He serves as Adjunct Professor at the George Washington University School of Medicine and CEO of the Institute for Human Optimization. Dr. Bajnath is certified through the Institute for Functional Medicine, board certified in anti-aging and regenerative medicine, and is one of the few clinicians actively applying genomics, transcriptomics, proteomics, and epigenetics together in a real clinical practice. 

Together, Dave and Dr. Bajnath break down why population-based medicine fails individuals, how functional medicine and precision science combine to unlock real human performance, and why your mitochondria sit at the foundation of every longevity strategy worth pursuing. They dig into how AI can help you decode your own inflammasome biology, why biohackers are using ?sex drugs? to extend longevity, why vagal nerve stimulation directly suppresses the NLRP3 inflammasome, and which biomarkers like MMP9 and homocysteine mainstream medicine keeps ignoring. They also cover peptides, supplements, the dark side of metformin, microdosing for anti-aging, and why biohacking works best when it's personalized and precise. 

This is essential listening for anyone serious about longevity, smarter not harder health strategies, metabolism, sleep optimization, brain optimization, functional medicine, and taking full control of their biology. 

 

You'll Learn: 

Why precision medicine outperforms population-based health strategies for human performance How to layer genomics, transcriptomics, and proteomics into one complete biological picture Which longevity biomarkers your doctor is likely ignoring, including MMP9 and homocysteine How vagal nerve stimulation suppresses the NLRP3 inflammasome and drives anti-aging benefits The real story on metformin, peptides, and which supplements actually move the needle How AI can help you understand your own biology and act on it faster Why biohacking precision beats random stacking every time 

Thank you to our sponsors!   

? Igniton | Head over to Igniton.com and use code DAVE for an exclusive 15% off your first order. 

? BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off  https://beyondconference.com 

? Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order. 

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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: precision medicine, biohacking, Dave Asprey Cialis, Anil Bajnath, American Board of Precision Medicine, multi-omics, genomics, transcriptomics, proteomics, epigenetics, NLRP3 inflammasome, vagal nerve stimulation, MMP9, homocysteine, mitochondria, longevity, anti-aging, peptides, BPC-157, metformin, rapamycin, functional medicine, human performance, supplements, EGCG, exposome, nitric oxide, vascular health, metabolism, brain optimization, AI health, biohacking technology, Dave Asprey Sex Drugs 

Resources:   

? Learn More About Anil?s Work And the Institute For Human Optimization At: https://ifho.org/ 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 ? Trailer 

00:53 ? Intro to Precision Medicine 

01:58 ? Dr. Bajnath's Holistic Health Journey 

05:03 ? Pharmaceuticals vs. Supplements 

07:58 ? Peptides and Longevity Molecules 

10:34 ? Sexual Health and Vitality 

13:56 ? Vascular Health and Blood Flow 

15:14 ? Multi-Omics Approach 

19:03 ? DNA and Genomics 

22:17 ? Transcriptomics and RNA 

24:24 ? Proteomics and Inflammation Markers 

32:00 ? The Human Exposome 

34:55 ? Key Health Biomarkers 

36:58 ? Cell Membrane Dynamics 

40:28 ? Biological Investment Strategy 

41:53 ? Life Extension Possibilities 

48:52 ? Bioenergetics and Mitochondria 

49:47 ? Quantum Medicine and the Future 

51:33 ? Vagal Nerve Stimulation 

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What if the secret to living longer wasn't locked in a lab, but hiding in plain sight? And what could lobsters possibly teach us about staying young?

Scientists have discovered a remarkable connection between an ancient practice and our cellular aging process - one that celebrities and longevity researchers are quietly using to their advantage. It involves an enzyme in your body that most people don't even know exists, yet it plays a crucial role in how fast (or slow) you age.

The twist? You can activate it in just 10 minutes a day, no prescription required.

Curious about the biological "switch" that might help you turn back your cellular clock? The answer might surprise you...

Thank you to our sponsors! 

-AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers.

-Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave

Resources:   

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com  

0:00 ? Introduction

0:46 ? Lobsters and Human Longevity Connection

1:14 ? Understanding Telomeres and Aging

2:26 ? How Lobsters Defy Aging

3:32 ? Rethinking Aging Biology

4:53 ? The Telomerase Challenge

6:43 ? Natural Ways to Protect Telomeres

9:33 ? Meditation's Role in Anti-Aging

11:04 ? Different Meditation Techniques

13:19 ? Benefits and Long-Term Effects

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week?s stories: 

Sinclair?s This Is the Test: Are we about to see age reversal in humans? 

At the World Governments Summit 2026 in Dubai, Harvard geneticist David Sinclair told world leaders that ageing could soon be reversible and said the first human clinical trials of epigenetic reprogramming therapies are moving forward. The core idea is that ageing is partly an information problem, how cells read DNA, not just cumulative damage, and that partial reprogramming could restore youthful function without turning tissues into tumors. Dave frames this as a rare binary moment for longevity: either early, localized human trials (starting with tightly controlled tissue targets like the eye) show meaningful functional rejuvenation with acceptable safety, or the field has to recalibrate fast. Either way, the next couple of years will heavily influence where money, regulators, and serious researchers place their bets.   

? Sources: 

? World Governments Summit: https://www.worldgovernmentssummit.org/media-hub/news/detail/ageing-could-soon-be-reversible-says-harvard-scientist-at-wgs-2026   

? NAD / Life Biosciences coverage: https://www.nad.com/news/fda-greenlights-life-biosciences-human-study-setting-up-pivotal-test-for-aging-theory-from-harvards-david-sinclair   

 

AlphaFold 4 in a locked box: DeepMind?s private AI drug design engine 

Isomorphic Labs, DeepMind?s drug discovery company, unveiled a proprietary drug design engine that outside scientists are comparing to an AlphaFold 4 moment, but for designing drugs, not just predicting structures. The big shift is that this system is closed: no public weights, no open database, and access appears to flow through partnerships with pharma companies. Dave breaks down why that matters for the longevity world: if AI makes early discovery cheaper and faster, we might see more serious shots on ageing targets over the next decade, but a closed model can also mean less transparency, bigger IP moats, and no guarantee that faster discovery leads to cheaper drugs.   

? Sources: 

? Nature: https://www.nature.com/articles/d41586-026-00365-7   

? Isomorphic Labs: https://www.isomorphiclabs.com/articles/the-isomorphic-labs-drug-design-engine-unlocks-a-new-frontier   

Peptides in the freezer: El Mencho?s anti aging stash and the dark side of wellness 

After reports and images from the final hideout linked to Jalisco New Generation Cartel leader Nemesio Oseguera Cervantes (El Mencho), coverage highlighted a detail that feels uncomfortably familiar to anyone in the modern wellness internet: injectable vials stored in a freezer with a schedule attached, including Tationil Plus, a glutathione based injectable marketed in some places for ?cellular health,? cosmetic effects, and anti ageing. Dave uses the absurdity as a narrative wedge, not cartel gossip, to talk about how normalized gray market injectables have become, and how marketing (?detox,? ?cellular reset?) often outruns evidence and safety. The segment pivots into a practical filter: which compounds are real therapeutics under medical supervision, and which are expensive folklore with sourcing risk and unknown long term downsides.   

? Sources: 

? New York Post: https://nypost.com/2026/02/25/world-news/inside-the-luxurious-love-nest-where-mexican-drug-lord-el-mencho-spent-his-final-days/   

? Sky News (Reuters photos referenced): https://news.sky.com/story/inside-the-mexican-villa-where-feared-drug-lord-el-mencho-spent-final-hours-13511954   

? Reuters photo gallery: https://www.reuters.com/pictures/el-menchos-last-hideout-inside-villa-where-cartel-leader-spent-final-hours-2026-02-25/W7DK5WEXS5IMLLZQO2P3CXGXFM   

 

The disease we thought was dead: measles comes roaring back 

Measles cases have surged in early 2026, with reporting citing at least 588 cases in the U.S. by late January, already more than many full year totals, and additional updates showing continued acceleration into February. Dave reframes this as a healthspan floor issue: you can argue about peptides and mitochondria all day, but measles is so contagious that once community immunity drops, outbreaks move fast and hit the most vulnerable first, especially infants and immunocompromised people. He also flags the systems problem: many clinicians have never seen measles, which increases the odds of delayed recognition and wider exposure in waiting rooms. The actionable move is boring and high ROI: verify MMR status for you and your family and close gaps before outbreaks get closer to home.   

? Sources: 

? AMA Morning Rounds (Week of Feb. 2, 2026): https://www.ama-assn.org/about/publications-newsletters/top-news-stories-ama-morning-rounds-week-feb-2-2026   

? ABC News (CDC case count coverage): https://abcnews.com/Health/588-us-measles-cases-reported-january-cdc/story?id=129699078   

? CIDRAP (case tracking context): https://www.cidrap.umn.edu/measles/us-measles-cases-soar-588-so-far-year-south-carolina-confirms-58-new-infections   

 

DC vs your health: Trump?s State of the Union health reset 

President Donald Trump?s 2026 State of the Union included a cluster of healthcare themes that function as a directional signal for agencies and payers this year, including drug pricing rhetoric, price transparency, and broader coverage and affordability framing. Dave translates the politics into a practical heuristic for biohackers: federal posture quietly determines what becomes easy versus painful to access in the legitimate system, from GLP 1 coverage rules and prior auth behavior to how friendly the environment is for telehealth, at home diagnostics, and eventually whatever ?real longevity medicine? looks like. You do not need every policy detail in a weekly rundown, just the weather report: reimbursement and enforcement trends shape what stays niche, what scales, and what gets friction.   

? Sources: 

? Advisory Board: https://www.advisory.com/daily-briefing/2026/02/25/health-policy-roundup   

? Healthcare Dive: https://www.healthcaredive.com/news/trump-state-of-the-union-healthcare-2026/812962/   

? This Week in Public Health analysis: https://thisweekinpublichealth.com/blog/2026/02/25/the-2026-state-of-the-union-what-it-means-for-health-and-public-health/ 

 

All source links are provided for direct access to the original reporting and research. 

 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack. 

 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

 

Keywords: David Sinclair age reversal, epigenetic reprogramming therapy, Yamanaka factors OSK, Life Biosciences clinical trial, human rejuvenation trial 2026, biological age reset, longevity breakthrough news, DeepMind Isomorphic Labs, AlphaFold 4 drug design, AI drug discovery engine, geroprotective drug development, peptide gray market risks, injectable glutathathione Tationil Plus, GLP-1 regulation FDA warning, wellness industry regulation, measles outbreak 2026 US, MMR vaccine status adults, vaccine trust public health, health policy 2026 State of the Union, GLP-1 access and reimbursement, telehealth longevity care, biohacking news, anti-aging research update 

 

Thank you to our sponsors!  

-MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order.

-BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.

Resources:   

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps: 

0:00 - Introduction 

0:30 - Story #1: David Sinclair 2026 

2:13 - Story #2: Google Drug Discovery 

3:48 - Story #3: El Mencho Biohacking

5:30 - Story #4: Measles Outbreak 

6:51 - Story #5: Trump State of the Union 

8:00 - Weekly Roundup 

9:10 - Closing 

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Peptides can change how you heal, lean out, build muscle, and age, but only if you stop taking influencer advice and start thinking like a scientist. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

-Get a discount from BIOLONGEVITY LABS by using code ?Dave? at: https://biolongevitylabs.com/ 

Host Dave Asprey sits down with Josh Felber and Jay Campbell for a deep, practical conversation on what peptides actually are, how they work in the body, and how to use them without doing something dumb. Josh Felber and Jay Campbell are both cofounders of BioLongevity Labs and longtime leaders in the peptide and performance space. Josh is also the host of the Making Bank podcast and a serial entrepreneur in health. Jay has spent more than a decade researching and teaching advanced peptide protocols and performance strategies. 

They break peptides down in plain English as chains of amino acids that act like signaling molecules, then get into what matters in the real world: delivery methods, dosing, and why pharmacokinetics and timing decide whether something works. You?ll hear why peptide pens feel like a huge upgrade over vials and syringes, why Dave wants patches and microneedle tech next, and how convenience can make the difference between consistency and quitting. 

Dave and the guys also go deep on mitochondria and longevity. They talk about SS31, now called elamipretide, and why it focuses on mitochondrial membranes and cardiolipin. They cover MOTS-c as a ?turbocharger? peptide that people often feel fast, especially if they feel metabolically sluggish. They get into growth hormone peptides like Tesamorelin, Ipamorelin, and CJC, plus why MK-677 sounds convenient but can come with tradeoffs like appetite and other downstream effects. 

Then the conversation turns into what?s new. Jay shares what he claims is a new long-acting folistatin-style compound called FLGR 242, designed to stay active for weeks. He frames it as a potential solution for GLP users who worry about losing muscle. They also talk about Klotho, what it does in aging, why it is hard to stabilize, and why Jay believes small dosing matters because of kidney risk at higher levels. Dave ties Klotho back to endothelial function and kidney protection, and they swap stories about what people report noticing. 

You?ll Learn: 

? What peptides are, explained without jargon 

? Why delivery matters and why pens beat mixing vials all day 

? How PK curves change real results and dosing schedules 

? What elamipretide means for mitochondria and longevity 

? Why MOTS-c can feel like a fast energy shift for some people 

? How Tesamorelin, Ipamorelin, and CJC fit into growth hormone support 

? Why MK-677 sounds easy but can bring unwanted effects 

? What Jay claims FLGR 242 does for myostatin, muscle, and fat loss 

? Why Klotho shows up in longevity research and why dose matters 

Thank you to our sponsors!   

? 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Generation Lab | Go to https://www.generationlab.com/ and use code Dave20 for $20 off to see what your body is really doing beneath the surface. 

? Pique | Establish a powerful foundation for sustained wellness at https://www.piquelife.com/DAVE and unlock 20% off. 

? Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: peptides, biohacking, Dave Asprey, Jay Campbell, Josh Felber, BioLongevity Labs, mitochondrial peptides, elamipretide SS31, MOTS-c, growth hormone peptides, Tesamorelin, Ipamorelin, CJC-1295, MK-677, folistatin, myostatin inhibitor, FLGR 242, Clotho peptide, longevity science, anti-aging, human performance, muscle growth, fat loss, GLP-1 muscle preservation, pharmacokinetics, peptide dosing, nootropics, functional medicine, metabolism, endothelial function, kidney protection 

Resources:   

? Get a discount from BIOLONGEVITY LABS by using code ?Dave? at: https://biolongevitylabs.com/ 

? Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

 

Timestamps: 

0:00 ? Trailer 

1:22 ? Introduction to Peptides 

7:52 ? Peptide Delivery Systems & Pens 

14:22 ? Safety & Regulation of Peptides 

19:22 ? SS-31 & Mitochondrial Health 

26:22 ? Blending Peptides & Cross-Linking 

38:22 ? Growth Hormone Peptides 

44:22 ? FLGR-242: The New Myostatin Inhibitor 

54:22 ? Melanin & Consciousness 

57:22 ? Klotho: The Longevity Peptide 

59:25 ? Regulatory Landscape & Future of Peptides 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your skin is not just a cosmetic surface. It?s a living organ that responds to signals, and the right light signal can flip your biology into repair mode. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

-Get a discount from LYMA by using code ?DAVE-10? at: https://lyma.life/ 

-Offer not valid on LYMA Laser PRO or LYMA Youth System

In this episode, Host Dave Asprey goes to London to meet Lucy Goff, founder of LYMA, at the LYMA headquarters. Lucy and her scientific team engineered a rare kind of at-home cold laser that delivers precise 808nm light with deep penetration, without burning, cutting, or ?damaging to rebuild.? Their work is backed by published research in the Aesthetic Surgery Journal, and they?ve tested gene expression in human dermis, including a reported sixfold increase in SIRT1, a major longevity pathway. This is why you can trust this conversation. It?s not vibes, it?s engineering, biology, and data. 

Most ?red light? products are basically glorified LEDs. They can be fine for the surface, but they do not deliver the kind of coherent, polarized, monochromatic light that your cells actually respond to in deep tissue. That matters because your mitochondria run the whole show. When mitochondria get a clean signal and more usable energy, your body suddenly has budget for repair, collagen, circulation, and recovery. That is the real mechanism behind anti-aging that does not rely on controlled injury. 

We get into how this kind of light hacking can change skin quality, muscle support under the skin, and even scars and fascia. We talk cartilage, knees, jowls, pigmentation, and the weird reality that you might not feel anything while it?s working. Dave also shares his early biohacking experiments using light for brain optimization, including the time he overdid it and temporarily scrambled his speech. That story will make you respect the power of light as a biological tool. 

We also talk human performance and travel. Dave breaks down how he uses light management for sleep optimization and jet lag, and why controlling light is as important as controlling food, fasting, ketosis, and metabolism. There?s also a practical angle here that most people miss: with AI, you can now take dense PubMed research and translate it into usable decisions without needing a PhD, which changes how fast you can learn, test, and personalize. 

If you care about longevity, neuroplasticity, recovery, and looking younger without trashing your tissue, this episode gives you a smarter way to think about lasers, supplements, nootropics, and the whole functional medicine stack. This is Smarter Not Harder biohacking, with a laser. 

You?ll Learn: 

? Why LED ?red light therapy? is not the same as laser-based mitochondrial activation 

? How coherent light influences mitochondria, collagen quality, and anti-aging repair 

? What gene expression changes like SIRT1 suggest about longevity signaling 

? How light may support brain optimization, circulation, and neuroplasticity 

? Why scars and fascia can disrupt performance, and how light can support remodeling 

? How Dave uses light and lifestyle hacking for sleep optimization, travel, and metabolism 

? How AI makes research-driven biohacking more accessible and more personal 

Thank you to our sponsors!  

? KILLSwitch | If you?re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off

? BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off  https://beyondconference.com

? fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.

? EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: cold laser therapy, 808nm laser, LYMA laser, infrared light therapy, red light vs laser, mitochondrial activation, SIRT1 gene expression, longevity biohacking, anti aging skin tech, collagen regeneration, fascia repair, scar healing laser, pigmentation removal light, brain optimization light therapy, neuroplasticity support, circulation enhancement, human performance recovery, functional medicine tools, Dave Asprey biohacking 

Resources:   

? LYMA Website (Use Code ?DAVE10? For A Discount: https://lyma.life/ 

? Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps: 

? 0:00 ? LYMA Laser Origin 

? 1:20 ? Dave?s Early Light Experiments 

? 5:15 ? Laser vs LED 

? 10:54 ? Safety and Diffusion Lens 

? 16:37 ? 808nm and the Brain 

? 19:36 ? Intimate Performance Effects 

? 26:03 ? Knee Before and After 

? 29:25 ? Vampire Bat and Veins 

? 37:36 ? 6x SIRT1 Activation 

? 42:42 ? Mitochondrial Signaling 

? 45:04 ? Veins and Pigmentation 

? 52:14 ? Scar Recovery 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most people try to fix brain fog and focus issues with caffeine or nootropics, but those approaches only mask the problem.

This video explains that brain fog begins when the brain?s energy system?its mitochondria?starts to fail, long before any obvious signs of aging appear.

Modern stress, poor sleep, artificial light, toxins, and blood sugar swings quietly drain this energy and reduce the brain?s ability to repair itself.

It then explains how methylene blue, a well-studied compound with a long medical history, works inside brain cells to improve energy production, protect neurons, and support lasting clarity when used correctly and safely.

Thank you to our sponsors! 

ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask.Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body?s really doing behind the surface.

Resources:   

? Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com  

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode covers: 

? Microplastics Are Destroying Male Fertility and Metabolism 

New research is putting microplastics in a category most men still are not taking seriously: direct reproductive and hormone risk. A 2024 study detected microplastics in every human testicle examined, with polyethylene and PVC among the most common polymers. PVC is especially relevant because it?s often tied to chemical additives that can disrupt endocrine signaling. The broader body of evidence points to micro- and nanoplastics crossing barriers like the blood?testis barrier, driving inflammation and oxidative stress in the testes, and showing associations with impaired sperm quality and hormone disruption. The longevity move here is reducing overall load: better water filtration, less plastic food contact, no heating food in plastic, fewer packaged foods, and taking indoor dust and air quality seriously, especially for men thinking about fertility now or hormone resilience over decades. 

? Sources: 

? Study (PubMed): https://pubmed.ncbi.nlm.nih.gov/38745431/   

? Coverage: https://people.com/microplastics-in-every-human-testicle-infertility-8651215   

? Fear of Aging Is Linked to Faster Biological Aging 

A new study ties aging anxiety to measurable acceleration in biological aging using DNA methylation clocks. People who reported more worry and negative beliefs about aging showed faster epigenetic aging signals, and the molecular differences clustered around stress and inflammatory pathways. In plain terms, chronic threat-mode thinking around aging maps onto biology that looks older on the clocks. For a longevity audience, this is a practical reminder that mental inputs affect physiological outputs. If your day-to-day mindset is constant pressure and decline narratives, that can show up downstream in stress biology and inflammatory tone. A smarter play is building a longevity framework around function, strength, purpose, and community, alongside the usual pillars like sleep, training, and metabolic health. 

? Source: https://medicalxpress.com/news/2026-02-older-links-health-faster-epigenetic.html   

? Additional source: https://www.nyu.edu/about/news-publications/news/2026/february/aging-anxiety.html   

? Retatrutide, the Triple-Agonist Weight-Loss Drug Pushing Bariatric-Level Results 

Retatrutide is a triple agonist that targets GLP-1, GIP, and glucagon receptors, and the weight-loss numbers being reported are massive. In a 68-week study in people with obesity and knee osteoarthritis, the highest dose group averaged about 28.7% body-weight loss, along with meaningful improvements in knee pain and function. This is the next phase of incretin medicine: multi-agonist drugs that can move body weight by a quarter or more. For biohackers, the performance and longevity angle is implementation: preserving lean mass through resistance training, hitting protein targets, monitoring micronutrients, and building a maintenance plan that doesn?t collapse the moment the drug stops. The upside is cardiometabolic risk reduction at scale. The key is running it with structure. 

? Sources: 

? Eli Lilly release: https://investor.lilly.com/news-releases/news-release-details/lillys-triple-agonist-retatrutide-delivered-weight-loss-average   

? Coverage: https://nypost.com/2026/02/18/health/people-dropped-out-of-retatrutide-trial-for-losing-too-much-weight/   

? Background: https://news.harvard.edu/gazette/story/2026/02/whats-next-for-glp-1s/   

? AI Can Predict 130 Diseases From a Single Night of Sleep 

Stanford?s SleepFM project shows how much long-horizon health information is encoded in sleep. Researchers trained a foundation model on roughly 585,000 hours of clinical polysomnography data from about 65,000 people. From a single night of sleep study signals, the model could estimate risk for 130 conditions, including dementia, heart attack, heart failure, chronic kidney disease, stroke, atrial fibrillation, and all-cause mortality, and it generalized across cohorts better than simple demographic baselines. The big implication is that sleep architecture and micro-patterns (stage distribution, fragmentation, breathing stability, micro-arousals) function like a dense biomarker stream for systemic aging and disease risk. Expect better sensors and more validated risk dashboards over time. Right now, this is another reason to treat sleep as a core diagnostic pillar, not just a recovery habit. 

? Sources: 

? Stanford Medicine: https://med.stanford.edu/news/all-news/2026/01/ai-sleep-disease.html   

? Paper (Nature Medicine): https://www.nature.com/articles/s41591-025-04133-4   

? Living at High Altitude May Protect Against Diabetes by Turning Red Blood Cells Into Glucose Sinks 

For years, population data has suggested lower diabetes rates at higher elevations. New mechanistic work is pointing to a surprising driver: red blood cells changing how they handle glucose under low oxygen conditions. In hypoxia, red blood cells can behave like glucose sinks, pulling more sugar out of circulation and improving glucose tolerance, which may help explain the protective association seen at altitude. The downstream potential is a new class of altitude-mimetic approaches that target erythrocyte metabolism as a glucose lever, separate from appetite suppression or classic diabetes pathways. For biohackers, it expands the metabolic toolkit and reinforces that oxygen environment and blood physiology matter more than we?ve given them credit for. 

? Source: https://medicalxpress.com/news/2026-02-red-blood-cells-sugar-high.html   

? Dietary Supplement Regulatory Uniformity Act and the Future of Supplement Access 

A proposed bill is aiming to stop states from layering extra rules on dietary supplements beyond federal law, creating one national standard instead of a patchwork of state-by-state restrictions. Industry groups are supporting it as a way to reduce confusion and compliance chaos, especially as some states explore age limits or special labeling requirements for certain supplement categories. The strategic implication for biohackers is that regulation shapes access. Uniformity can stabilize availability, but it also raises the stakes of federal decisions on controversial ingredients. This is one of those policy stories that quietly determines what stays on shelves, what disappears, and how much innovation survives in the supplement space. 

? Sources: 

? NutritionInsight: https://www.nutritioninsight.com/news/npa-crn-supplements-us-fda-legislation.html   

? Congressional release: https://langworthy.house.gov/media/press-releases/congressman-langworthy-introduces-dietary-supplement-regulatory-uniformity-act   

? NutraIngredients: https://www.nutraingredients.com/Article/2026/02/05/new-bill-aims-to-end-state-supplement-regulations/   

All source links are provided for direct access to the original reporting and research. 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

Keywords: microplastics male fertility, microplastics testosterone decline, blood?testis barrier toxins, endocrine disruption plastics, sperm count microplastics, epigenetic age acceleration, fear of aging methylation, biological aging mindset, stress inflammation aging, retatrutide triple agonist, GLP-1 GIP glucagon weight loss, incretin drugs obesity treatment, muscle preservation on GLP-1, SleepFM AI model, sleep disease prediction, polysomnography risk scoring, dementia risk sleep data, altitude diabetes protection, hypoxia glucose metabolism, red blood cells glucose uptake, altitude mimetic therapy, Dietary Supplement Regulatory Uniformity Act, supplement regulation federal preemption, FDA supplement policy, biohacking news longevity, metabolic health optimization  

Thank you to our sponsors!  

- HeartMath | Go to https://www.heartmath.com/dave to save 15% off. 

- BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. 

Resources:   

? Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps: 

0:00 ? Intro 

0:19 ? Story 1: Microplastics in Testicles 

1:44 ? Story 2: Fear of Aging Accelerates Aging 

3:30 ? Story 3: Retatrutide Weight Loss Drug 

4:42 ? Story 4: Sleep Predicts Disease Risk 

6:34 ? Story 5: High Altitude & Diabetes 

7:57 ? Story 6: Supplement Regulation Bill 

9:16 ? Weekly Summary 

10:51 ? Outro 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Meet a man who makes miracles happen. Today, we revist my conversation with Hal Elrod, author of the international bestseller The Miracle Morning and his newest book, The Miracle Equation. After overcoming multiple near-death experiences and financial hardships, Hal channeled his adversity into helping others overcome their own challenges. His Miracle Morning approach has impacted millions of lives. 

On today?s episode, Hal tells us all about his updated version of The Miracle Morning. He explains SAVERS, the six foundational practices that will transform your morning and change your life. We also talk about tips for hacking your sleep, productivity, and relationships.  

Hal shares the stories of his devastating car accident and rare cancer diagnosis, and the superpowers he gained from coming back to life. We explore how these near-death experiences changed his perspective on life and what he values most. He also tackles some tough questions? Should we try to help everyone? What does it mean to be a ?man?? And what does it take to truly serve others? There?s so much to take away from Hal?s refreshing and optimistic perspective. 

You?ll Learn: 

? What the SAVERS morning routine is and how to customize it from 6 to 60 minutes for any schedule 

? How Hal Elrod survived cancer with a 20-30% survival rate by combining chemotherapy with holistic practices 

? Why affirmations fail when done wrong and the 3-part formula that actually programs your subconscious mind 

? How emotional optimization meditation works, choosing your optimal mental state before meditating instead of just clearing your mind 

? Why the Miracle Morning doesn't require waking up early and how shift workers can do it at any time 

? What the SLUMBERS evening routine includes for better sleep: blue light blocking, natural supplements, and bedtime affirmations 

Thank you to our sponsors!  

? AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers. 

? BEYOND Biohacking Conference 2026 | Register now at https://beyondconference.com/ 

? Puori | Use code DAVE at puori.com/DAVE to get 32% off your Puori Fish Oil when you start a subscription. You save more than $18. 

? GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what?s in your air. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: miracle morning updated edition, hal elrod cancer survival, SAVERS routine explained, emotional optimization meditation, SLUMBERS evening routine, how to do affirmations correctly, flexible morning routine, shift worker morning routine, holistic cancer treatment, combining chemo and holistic practices, valerian root sleep, blue light blocking glasses, masculine feminine energy balance, daveasprey hal elrod, miracle morning new book 

Resources:   

? Hal Elrod?s Website: https://halelrod.com/ 

? Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)   

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com   

Timestamps: 

? 00:00 ? Introduction  

? 02:35 ? Coffee and The Miracle Morning 

? 08:38 ? Accountability and Habit Apps 

? 13:44 ? Vegan Journey and Diet Shifts 

? 20:58 ? Near-Death Experience 

? 22:04 ? Cancer Diagnosis and Treatment 

? 29:41 ? Spiritual Insights 

? 33:12 ? Helping Others 

? 43:09 ? Masculinity and Partnership 

? 53:33 ? The SAVERS Framework 

? 56:19 ? Evening Routine and SLUMBERS 

? 1:03:06 ? Intimacy and Energy 

? 1:09:01 ? Emotional Optimization 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your gray hair, thinning lashes, brain fog, and that low energy feeling after 30 might all trace back to one thing: falling NAD and stressed mitochondria. This episode breaks down what actually happens inside your cells as NAD declines, and what you can do about it using specific compounds from mushrooms, olive oil, and even chocolate. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

-Wonderfeel is gifting a 7-day Youngr? supply (mini pouch) with every Youngr? order. The code is DAVE, and the campaign will be active throughout the month: https://getwonderfeel.com/dave/?utm_source=Dave&utm_medium=podcast&utm_campaign=episode2

Host Dave Asprey sits down with Baran Dilaver, CEO and co-founder of Wonderfeel Biosciences, to unpack the real science behind NAD, mitochondrial energy, and long-term longevity. Baran is an entrepreneur and inventor who previously led multiple start-ups as CEO and COO, collaborated with leading scientists and medical experts, and developed award-winning products. A UC Berkeley economics graduate and former scholarship athlete, he now focuses on translating cutting-edge bioscience into practical tools that enhance people?s lives. 

They break down how NAD powers mitochondria, why your body strategically allocates cellular energy away from peak cognitive performance as you age, and how stress accelerates that decline. You?ll hear the differences between niacinamide, NR, and NMN, the FDA confusion around NMN, and why raising NAD is about cellular repair, resilience, and metabolic function, not just ?more energy.? 

The conversation goes deep on hydroxytyrosol, the powerful olive oil polyphenol that acts as a CD38 inhibitor, and ergothioneine, a mushroom-derived antioxidant with its own receptor in the human body that can accumulate in damaged tissues. Baran shares the origin story that pushed him to research ergothioneine, along with anecdotal observations from long-term users reporting improvements in sleep, focus, energy, thicker hair, reduced gray hair, and even eyelash regrowth. 

You?ll also hear Dave?s practical take on ketosis, fasting, supplements, and metabolism, why he prefers NAD precursors over IV NAD for most people, how methyl donors affect NAD IV tolerance, and why Wonderfeelbuilt a creatine chocolate bar sweetened with allulose to stay keto-friendly and diabetic-friendly. This is biohacking grounded in mechanism, from mitochondria and neuroplasticity to anti-aging strategy and smarter supplementation. 

You?ll Learn: 

? What NAD does in the body and why oral NAD itself is not effective 

? How niacinamide, NR, and NMN compare as NAD precursors 

? Why mitochondria control energy allocation, cognition, and resilience 

? How hydroxytyrosol may support NAD longevity through CD38 inhibition 

? What ergothioneine is, why it comes from mushrooms, and why the body has a receptor for it 

? What long-term users commonly report: better sleep, clearer thinking, stronger energy, and cosmetic shifts 

? Why Dave prefers supplements over NAD IVs in most cases 

? How allulose differs from other sweeteners and why it matters for metabolism 

? Why creatine supports brain energy and how heat changes absorption strategy 

Thank you to our sponsors!  

? MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order 

? Branch Basics | Get 15% off at https://branchbasics.com/DAVE15 with code DAVE15 

? Timeline | Go to timeline.com/Dave for 20% off

? OneSkin | Try OneSkin at https://www.oneskin.co/DAVE and use code DAVE for 15% off 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: NAD supplementation, NMN benefits, NR vs NMN, nicotinamide mononucleotide, mitochondrial function, CD38 inhibition, hydroxytyrosol olive oil, ergothioneine mushrooms, mushroom antioxidant benefits, Alzheimer?s prevention strategies, brain fog after 30, mitochondrial energy production, anti aging supplements, longevity compounds, fertility mitochondrial health, NAD IV vs oral NMN, creatine for brain health, allulose sweetener benefits, keto friendly chocolate, GLP 1 natural support, biohacking longevity, neuroplasticity support, metabolism optimization, fasting and NAD levels, ketosis and mitochondria, supplement regulation FDA, functional medicine longevity, Dave Asprey biohacking, Wonderfeel NMN 

Resources:   

? Wonderfeel is gifting a 7-day Youngr? supply (mini pouch) with every Youngr? order. The code is DAVE, and the campaign will be active throughout the month: https://getwonderfeel.com/dave/?utm_source=Dave&utm_medium=podcast&utm_campaign=episode2

? Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

? Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

? Danger Coffee: https://dangercoffee.com/discount/dave15   

? My Daily Supplements: SuppGrade Labs (15% Off)  

? Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

? Dave Asprey?s BEYOND Conference: https://beyondconference.com   

? Dave Asprey?s New Book ? Heavily Meditated: https://daveasprey.com/heavily-meditated  

? Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

? Upgrade Labs: https://upgradelabs.com  

Timestamps: 

00:00 - Introduction 

01:13 - What Is Wonderfeel 

05:31 - NAD and NMN Explained 

09:41 - FDA Status of NMN 

13:50 - Supplements vs Pharmaceuticals 

16:48 - How NAD Powers Mitochondria 

25:46 - NAD Benefits and Effects 

30:57 - Hydroxytyrosol 

35:03 - Ergothioneine 

41:55 - Alzheimer?s and Brain Health 

44:10 - Vitamin D and K2 

46:15 - Sustainable Packaging 

49:26 - Creatine Bars 

51:43 - Allulose Deep Dive 

59:28 - Inflammation Research 

01:02:15 - Supplement Regulation 

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