Noor Siddiqui is building a future free of inherited disease. As Founder & CEO of Orchid, she has developed embryo screening technology that reads 99% of an embryo's DNA - 100 times more information than legacy tools. In this episode of Forecast 2050, Nebular General Partner Finn Murphy sits down with Noor in San Francisco to discuss why embryo screening and artificial wombs may become the default way humans reproduce, what's really driving falling birth rates, the moonshot nobody is funding, and why a generation of young people with world-changing energy has been left with nowhere to put it.

Extended Show Notes: https://finnmurphyirl.substack.com/p/sex-is-for-fun-orchid-ivf-is-for

Transcript (with links): https://finnmurphyirl.substack.com/p/forecast-2050-transcript-episode

Chapters:

00:00 Intro

00:50 Rolling the Dice No More: The Embryo Screening Revolution

05:27 Artificial Wombs Are the Tech Challenge of Our Time

07:47 Why Aren't We Having Kids?

17:03 The Broken Generational Contract

18:56 Nature Beats Out Nurture

21:45 AI & Genetic Technology Could Give Us Superhuman Powers

30:54 Noor?s Plan for 2050

37:10 What We Lose When Old People Run Everything

Noor Siddiqui is the Founder & CEO of Orchid, the world's first whole genome embryo screening company.

Noor on X: https://x.com/noor_siddiqui_

Orchid: https://www.orchidhealth.com/

Forecast 2050 is a series about the next 25 years?and the builders, thinkers, and leaders shaping what comes next.

Finn on X: https://x.com/FinnMurphy12

Finn on LinkedIn: https://www.linkedin.com/in/finn-murphy-16160465/

Nebular is a venture capital firm based in New York City investing in early-stage companies.

Head to nebular.vc for more info.

Scott Aaronson thinks that the time to prepare for a post-quantum world isn?t years away - it was yesterday. In the second episode of Forecast 2050 with Nebular General Partner Finn Murphy and Entrepreneur in Residence Tom McCarthy, we explore whether classical AI might eclipse quantum computing, how post-quantum cryptography will upend global security, and why the rise of superintelligence both excites and deeply unsettles Scott.

We also debate whether a quantum teleporter would actually be a suicide machine, how advanced AI might help us uncover the fundamental nature of reality, and the disturbing possibility that future superintelligences may compete with one another for dominance, treating humans as collateral.

Extended Show Notes: https://finnmurphyirl.substack.com/p/breaking-the-internet-scott-aaronsons

Transcript (with links): https://finnmurphyirl.substack.com/p/forecast-2050-episode-ii-transcript

Chapters

00:00 Intro

02:04 How AI & Quantum Computing Interact Today

10:36 Why Scott Thinks Classical Computing Might Outdate Quantum

18:24 The Post-Quantum World of 2050

27:43 Quantum Computing & Biology

35:46 The Quantum Teleporter as a Suicide Machine

38:52 Superintelligence & The Ultimate Nature of Reality

45:00 The Battle Between Superintelligences

Scott Aaronson, the Schlumberger Centennial Chair of Computer Science at the University of Texas at Austin, is widely recognized as a top researcher in the fields of quantum computing and computational complexity.

Thank you to Matt Johnson of Q2B Sillicon Valley and QC Ware for helping us film at the conference!

https://q2b.qcware.com/

Scott?s blog, Shtetl-Optimized: https://scottaaronson.blog/

Forecast 2050 is a series about the next 25 years?and the builders, thinkers, and leaders shaping what comes next.

Finn on X: https://x.com/FinnMurphy12

Finn on LinkedIn: https://www.linkedin.com/in/finn-murphy-16160465/

Tom on LinkedIn: https://www.linkedin.com/in/tom-mccarthy-41144779/

Nebular is an early-stage venture capital firm based in New York City.

Head to nebular.vc for more info.

Tyler Cowen believes we are woefully unprepared for the next 25 years.

In the first episode of Forecast 2050 with Nebular General Partner, Finn Murphy, we discuss the real reason behind falling birthrates, what the last human job might be in an AI-dominated economy, how conflict and war could evolve in the next 25 years, whether we will have a "viagra for the mind," why we are experiencing the fastest technological revolution in human history, why humans love stasis and hate change, and why we need faith in long-term thinking.

Extended Show Notes: https://finnmurphyirl.substack.com/p/humans-love-stasis-and-hate-change

Transcript (with helpful links!): https://substack.com/home/post/p-189726563

Chapters:

00:00 Intro

01:03 The real reason behind low birthrates

04:50 Transitioning to a majority-old society

07:49 The future of worldwide immigration

14:55 The 2050 economy will be healthcare dominated

19:23 Corporations have never been so powerful

26:25 There is life on the moons of Saturn

27:07 Elon is wrong: We won't settle other planets

30:00 AIs Will Take Over Society By Trick

30:58 We need faith for long term thinking

32:47 There will be many, many fake jobs

36:29 The future of the UN and global conflicts

40:56 The AIs will build their own superintelligent institutions

45:18 Tyler's greatest concern

47:50 The last profession standing in the AI era

Tyler Cowen is an economist, author, and professor known for his work on growth, innovation, and the future of technology.

Tyler on X: https://x.com/tylercowen

Tyler's Blog: https://marginalrevolution.com/

Forecast 2050 is a series about the next 25 years?and the builders, thinkers, and leaders shaping what comes next.

Finn on X: https://x.com/FinnMurphy12

Finn on LinkedIn: https://www.linkedin.com/in/finn-murphy-16160465/

Nebular is an early stage venture capital firm based in New York City.

Head to nebular.vc for more info.

Forecast 2050 is a series about the next 25 years, and the builders, thinkers, and leaders shaping what lies ahead. Hosted by Nebular General Partner Finn Murphy.