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MeSsy with Christina Applegate & Jamie Lynn Sigler

MeSsy with Christina Applegate & Jamie Lynn Sigler

On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.

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messy-with-christina-applegate-jamie-lynn-sigler.simplecast.com

Episodes

What If You’re Not Stuck, You’re Just in Between? with Emmanuelle Chriqui

This week, Jamie is joined by her friend, actress Emmanuelle Chriqui. They talk about grief, the friendships that carry us through hard times, getting older, learning to separate your self-worth from your career, and more. 

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Novartis in neuroscience

Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-10-06
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I Don’t Have a Lot of Fight in Me Right Now

This week, Jamie reads listener emails and discusses parenting with MS, learning to embrace mobility aids, and navigating unsolicited advice and comparisons. 

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Novartis in neuroscience

Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at  https://mudwtr.com/MESSY! #mudwtrpod

Alloy -With Alloy, your best hair isn’t behind you. Visit https://MyAlloy.com and use the code MESSY to get 20 percent off your first order. Your menopause-specialized doctor will tailor your care to your needs — plus, you get zero dollar unlimited messaging with your doctor. This code is valid on products only.


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-09-29
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How to Live With What You Can’t Control with Ana Rodriguez

In the final episode of Living With It, Jamie sits down with her therapist, Ana Rodriguez, to talk about what it really means to heal when life doesn’t go according to plan. They explore grief, resilience, uncertainty, and the ways we avoid our feelings by trying to fix them or find meaning too quickly.

Novartis in neuroscience

o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-09-24
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The Hardest Fight Is Learning to Rest with Alberto Crane

This week, Jamie sits down with jiu-jitsu champion and former UFC fighter Alberto Crane to talk about how his MS diagnosis forced him to redefine what it means to be strong. Alberto opens up about learning to slow down, embrace rest, and why sometimes being a fighter means knowing when not to push through.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by: 


Novartis in neuroscience

Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

OneSkin - Get 15% off OneSkin with the code MESSYat https://www.oneskin.co/MESSY #oneskinpod

Zoc Doc - Ready to be seen? Check that appointment off your to-do list with Zocdoc https://zocdoc.com/ messy #sponsored


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-09-22
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Stop Apologizing for Wanting More with Heather Dubrow

This week on Living With It, Jamie sits down with Heather Dubrow for an honest conversation about embracing life’s pivots, protecting your peace, and giving yourself permission to want more. 

Novartis in neuroscience

o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-09-17
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There Is Beauty Within All of This Pain with Lindsey Kraft

This week on MeSsy, Jamie sits down with her longtime friend, actress, writer, and musician Lindsey Kraft. They talk about growing up together, navigating rejection and self-doubt, and Lindsey’s unexpected journey from acting to writing her own one-woman musical.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by: 

Take the MeSsy Survey - Please help out the show by taking our survey at https://messythepodcast.com/survey

Novartis in neuroscience

Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

Lola - Get 40% off select Lola Blankets products at https://lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.

K18 - Shop at Sephora or get 10% off your first purchase at https://k18hair.com with code MESSY. That’s code MESSY at k18hair.com



 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-09-15
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Falling Apart to Come Back Together with Ryan Weiss

This week on Living With It, Jamie sits down with her friend, Ryan Weiss. They talk about letting go of control, sitting with difficult emotions, knowing when it’s time to do things differently, and learning to trust what’s on the other side when life doesn’t look the way you thought it would.

Novartis in neuroscience

o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-09-10
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Thank God I’m So Neurotic with Cat Cohen

This week on MeSsy, Jamie sits down with comedian, actor, and singer Cat Cohen. Cat opens up about having a stroke at 31, navigating health anxiety in the aftermath, and turning one of the scariest experiences of her life into her most fulfilling creative work yet.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by: 

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

Jones Road - Use code MESS at https://jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad


 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-09-08
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We Fight For Joy with Kelsey Chittick

This week on Living With It, Jamie sits down with Kelsey Chittick to talk about losing her husband suddenly, raising two children through grief, and learning to build a life she never expected. They discuss finding humor in the darkest moments, letting go of the life you thought you’d have, the power of community, and how to choose joy.

Novartis in neuroscience

o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-09-03
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There’s No Place Like Home with Annie Meyers-Shyer

This week, Jamie is joined by her longtime friend Annie Meyers-Shyer, the creator behind This Oak House. They talk about Annie’s unexpected second act, finding a new passion and career at 45, and why it’s never too late to bet on yourself. Annie also shares how she creates a home that feels like an exhale, the small ways our spaces can support us through difficult seasons, and how her home carried her through grief. 

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by: 

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod

ZBiotics - Go to  https://zbiotics.com/messy and use MESSY at checkout for 15% off any first time orders of ZBiotics probiotics.



 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-09-01
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The Power of Radical Acceptance with Jim Curtis

This week on Living With It, Jamie sits down with Jim Curtis, a transformational coach, author, and wellness leader. They discuss how to radically accept the life you have without giving up hope for the life you want, the stories we build around our suffering, and learning to see your body as an ally instead of the enemy. Plus, Jim shares how releasing old beliefs and changing the way we speak to ourselves can open us up to new possibilities.

 

Novartis in neuroscience

o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-08-27
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Jamie's Son Beau

This week, Jamie sits down with a very special guest: her 13-year-old son, Beau. They have an honest conversation about what it’s been like growing up with a mom who has MS, how Jamie’s strength has shaped him, and what he wants other kids and parents living with chronic illness to know.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by: 

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

MudWtr -Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at  https://mudwtr.com/messy! #mudwtrpod

OneSkin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY  #oneskinpod

MyAlloy -Try the original estrogen-powered M4 skincare from Alloy. Visit myalloy.com and use code MESSYfor $20 off your first order!


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-08-25
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Accept, Adapt, Appreciate with Odette Annable

This week on Living With It, Jamie sits down with her friend Odette Annable. They discuss parenting a neurodivergent child, trusting your instincts, advocating for your family, and learning to let go of the need to have all the answers.

Novartis in neuroscience

o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-08-20
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The Courage to Slow Down

This week on MeSsy, Jamie opens up about reaching her limit and learning to make rest part of healing. She also reads listener emails about fighting to be heard by doctors, learning to accept help, and the power of knowing you're not alone.

 

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by: 

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

Lola Blankets - Get 40% off select Lola Blankets products at Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.

ZocDoc - Head to https://Zocdoc.com/MESSYto get started and check that appointment off your to-do list!


 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-08-18
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Finding Stillness When Life Won’t Slow Down with Bob Roth

This week on Living With It, Jamie sits down with Bob Roth, a leading Transcendental Meditation teacher and CEO of the David Lynch Foundation. They discuss what stress does to the body, how meditation can help calm the nervous system, and how finding stillness can help us navigate uncertainty, illness, and everyday life.

Novartis in neuroscience

o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-08-13
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How Death Informs How We Live with Julie McFadden

This week, Jamie sits down with hospice nurse Julie McFadden to talk about changing the way we think about death, what she’s learned from those at the end of life, and how accepting our mortality can help us live more fully in the present.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Novartis in neuroscience

Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

Take the MeSsy Audience Survey

https://www.messythepodcast.com/survey

Jones Road - Use code MESS at jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad

CBDistillery - Visit https://CBDistillery.com and use my code MESSY for 25% off. That’s C B Distillery dot com, code MESSYC B Distillery dot com.

K18 - Shop at Sephora or get 10% off your first purchase at https://k18hair.com with code MESSY. That’s code MESSY at k18hair.com

Radiance - For 20% off and FREE SHIPPING. Go to https://BRICKHOUSENUTRITION.com and use code - MESSY


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-08-11
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Trusting the Journey with Becca Tobin

This week, Jamie sits down with one of her best friends, Becca Tobin, for a conversation about infertility, pregnancy loss, surrogacy, and finding hope after years of uncertainty. They explore grief, resilience, the unexpected paths to parenthood, and what it means to keep moving forward when life doesn't unfold the way you imagined.

Novartis in neuroscience

o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-08-06
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Try to Find the Light with Amanda Kloots

This week, Jamie sits down with Amanda Kloots for an honest conversation about finding joy alongside heartbreak. Amanda opens up about losing her husband, Nick Cordero, how her grief has evolved over the past six years, why she no longer believes we have to "let go" of the people we love, and more.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Novartis in neuroscience

Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


Oak Essentials - Use codeMESSY at https://oakessentials.com to get 15% off your first purchase! #OakEssentials #ad

Zbiotics - Wedding season, bachelorettes, rooftop birthdays — August doesn't slow down and neither do you. Pre-Alcohol keeps it that way. https://ZBiotics.com/MESSYcode MESSY for 15% off.

Honeylove 0 Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod


 


 


 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-08-04
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Look for the Signs with Kate Doerge

On this episode of Living With It, Jamie sits down with Kate Doerge to discuss finding hope after profound loss, recognizing signs from loved ones, and the five actions that can transform the way we move through grief.

Novartis in neuroscience

o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-07-30
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Hope Can Exist Alongside Fear with Myriam Sandler

This week, Jamie sits down with Mothercould creator Myriam Sandler. They discuss her recent MS diagnosis, trusting your intuition, and finding hope even when life doesn't go as planned.


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

 

This episode is sponsored by:

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

OneSkin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY #oneskinpod

CBDistillery - Visit https://CBDistillery.com and use my code MESSY for 25% off. That’s C B Distillery dot com, code MESSY C B Distillery dot com.

Radiance - For 20% off and FREE SHIPPING. Go to https://BRICKHOUSENUTRITION.com and use code - MESSY


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-07-28
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It's Okay Not to Be Okay with Amy Kurtz

On the first episode of Living With It, Jamie sits down with Amy Kurtz, a patient advocate and author. They discuss the grief of chronic illness, learning to trust yourself again, and why healing is about so much more than getting better.

Novartis in neuroscience

o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-07-23
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All Eyes on Me

This week, Jamie reads listener emails and opens up about the feeling of all eyes on you when you're struggling, the anxiety of the lead up, caregiving, and more.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

CBDistillery - Visit https://CBDistillery.com and use my code MESSY for 25% off. That’s C B Distillery dot com, code MESSY C B Distillery dot com.

ZocDoc -Head to https://Zocdoc.com/MESSY to get started and check that appointment off your to-do list!

Radiance -For 20% off and FREE SHIPPING. Go to https://BRICKHOUSENUTRITION.com and use code - MESSY

Lola Blankets -Get 40% off select Lola Blankets products at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-07-21
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Tamsen Fadal

This week, Jamie sits down with journalist, author, and menopause advocate Tamsen Fadal. They discuss the physical and emotional realities of perimenopause, why so many women feel dismissed by the medical system, and how speaking honestly about aging, identity, and women's health can help us all feel less alone.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

Veracity - For up to 65% off your order, head to https://VeracityHealth.co and use code MESSY.

Rythm - Right now, Rythm is offering our listeners 15% off your first month and free shipping at ⁠https://rythm.health/messy⁠ Stop guessing, start testing. Rythm DOT HEALTH slash messy

Jones Road - Use code MESS at jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad




Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-07-14
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You Do Not Have to Become Someone Else to Heal

This week, Jamie reads listener emails and discusses the invisible weight of living with chronic illness, the courage it takes to keep showing up, and the small moments that can bring us back to ourselves. She also shares the reminder she received from a recent on stage performance.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

Zbiotics - Go to  https://zbiotics.com/MESSY and use MESSY at checkout for 15% off any first time orders of ZBiotics probiotics.

Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod

Rythm - Right now, Rythm is offering our listeners 15% off your first month and free shipping at https://rythm.health/messy   Stop guessing, start testing. Rythm DOT HEALTH slash messy 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-07-07
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Erin Moriarty

This week, Jamie sits down with Erin Moriarty. They discuss Erin's journey with Graves' disease while starring in "The Boys," the invisible toll chronic illnesses can take on your mental health, learning to advocate for yourself, and why vulnerability may be the greatest form of strength.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

Jones Road - Use code MESS at jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad

MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at  https://mudwtr.com/MESSY  #mudwtrpod
Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-06-30
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Mia Calabrese

This week, Jamie is joined by Summer House’s Mia Calabrese. She opens up about her journey with grief and what’s helped her to find joy again. They also discuss the Summer House scandal and Mia shares her thoughts on the reunion and bonus episode.


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

ZocDoc - Stop putting off those doctors appointments and go to https://Zocdoc.com/MESSY to find and instantly book a doctor you love today. 

MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at  https://mudwtr.com/MESSY  #mudwtrpod
OneSkin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY #oneskinpod



Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-06-23
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Choose Yourself

This week, Jamie reads emails from listeners. She also discusses mom guilt, PMS and MS, letting people know how their actions affect you, and much more. 

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

Q30 - For a FREE sleeve with your order, head to https://Q30.com/MESSY and use code MESSY.

Lola - Get 40% off select Lola Blankets products at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.

Veracity- For up to 65% off your order, head to https://VeracityHealth.co and use code MESSY.  

K18- Shop at Sephora or get 10% off your first purchase at https://k18hair.com with code MESSY. That’s code MESSY at k18hair.com




Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-06-16
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Our Favorite Bravo Men

This week, we are revisiting conversations with some of our favorite Bravo men - Jesse Solomon, Carl Radke, and Andy Cohen. They share moments that were challenging, helped them grow, and changed their perspectives on life. 


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

Jones Road - Use code MESS at jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad

Rythm - Right now, Rythm is offering our listeners 15% off your first month and free shipping at https://rythm.health/messy   Stop guessing, start testing. Rythm DOT HEALTH slash messy 

NOCD - If you're struggling with OCD or unrelenting intrusive thoughts, NOCD can help. Book a free 15 minute call to get started  https://learn.nocd.com/messy


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-06-09
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Aida Turturro

This week, Jamie sits down with the one and only Aida Turturro. They reflect on their years together on The Sopranos, and Aida discusses living with rheumatoid arthritis since childhood, perspective, and finding gratitude during difficult times.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod

Q30 - For a FREE sleeve with your order, head to https://Q30.com/MESSY and use code MESSY. 
Ridge - Upgrade your wallet today! Get up to 40% off @Ridge during their Father’s Day Sale when you go to https://www.Ridge.com/MESSY  #Ridgepod


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-06-02
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What the F*ck Is Normal Anyway?

This week, Jamie reads listener emails and discusses what it means to feel seen, the complicated balance between grief and gratitude, and why you don’t have to be “perpetually positive” to keep moving forward.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at  https://mudwtr.com/messy! #mudwtrpod

OneSkin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY #oneskinpod

Rythm - Right now, Rythm is offering our listeners 15% off your first month and free shipping at https://rythm.health/messy   Stop guessing, start testing. Rythm DOT HEALTH slash messy 

NOCD - If you're struggling with OCD or unrelenting intrusive thoughts, NOCD can help. Book a free 15 minute call to get started: https://learn.nocd.com/messy

Veracity - For up to 65% off your order, head to https://VeracityHealth.co and use code MESSY.  



Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-05-26
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Lena Hall

This week, Jamie is joined by Tony Award-winning actress and singer Lena Hall. They discuss being present in grief, the power of healing, finding your way back to yourself, and more.


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

Ridge - Upgrade your wallet today! Get up to 40% off @Ridge during their Father’s Day Sale when you go to https://www.Ridge.com/MESSY  #Ridgepod

Q30 - For a FREE sleeve with your order, head to  https://Q30.com/MESSY  and use code MESSY. 

Lola - Get 40% off select Lola Blankets products at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.

k18 - Shop at Sephora or get 10% off your first purchase at https://k18hair.com with code MESSY. That’s code MESSY at https://k18hair.com

Zoc Doc - Stop putting off those doctors appointments and go to https://Zocdoc.com/MESSY to find and instantly book a doctor you love today. 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-05-19
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Revisiting Our Convo with Martin Short

In honor of 'Marty, Life is Short,' we are revisiting our conversation with Martin Short. He reminisces, shares funny stories, discusses colonoscopy parties, and more.


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

Jones Road - Use code MESS at https://jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad

NOCD - Go to https://NOCD.com to book a free 15-minute call. 

OneSkin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY #oneskinpod 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-05-12
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A Conversation with Jamie’s Therapist

This week, Jamie sits down with her therapist, Ana Maria Rodriguez, who is a licensed clinical mental health therapist and the founder and owner of Selva Wellness Collective. They discuss how she helped Jamie through processing what came up while writing her memoir, the way the body stores trauma, ketamine therapy, and much more.


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.
Honey - loveSave 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod

Fatty15 - Get an additional 15% off their 90-day subscription Starter Kit by going to https://fatty15.com/messy and using code MESSY at checkout.


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-05-05
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The Friendship Episode

This week, Jamie is joined by her two best friends, Becca Tobin and Odette Annable. They discuss navigating friendships in all seasons of life, giving grace to yourself and others, finding your people, and more.


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Novartis in neuroscience

Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

Tumble - Machine Washable Rugs, Made Better. For a limited time only, our listeners get 10% off + free shipping at https://tumbleliving.com/MESSY #Tumble #ad

MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at https://mudwtr.com/MESSY! #mudwtrpod

One Skin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY #oneskinpod
Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy#honeylovepod


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-04-28
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A Conversation with Jamie's Husband

This week, Jamie is joined by her husband, Cutter Dykstra. They discuss his experience as her partner and caregiver, the role he's played in Jamie's acceptance and outlook, advice for other partners, and more.


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


Fatty15 - Get an additional 15% off their 90-day subscription Starter Kit by going to ⁠https://fatty15.com/messy⁠ and using code MESSY at checkout.

Lola - Get 40% off your entire order at ⁠https://Lolablankets.com⁠ by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.

Honeylove - Save 20% Off Honeylove by going to ⁠https://honeylove.com/messy⁠#honeylovepod

Jones Road - Use code MESS at ⁠https://jonesroadbeauty.com⁠ to get a Free Shimmer Face Oil with your first purchase! #JonesRoadBeauty

Zoc Doc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a doctor you love today. 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-04-21
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A MeSsy Update!

We’re taking a short break for the next few weeks while Jamie and Christina focus on their book launches. We’ll be back soon with brand new episodes!


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-03-31
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Olivia Munn

This week, Christina and Jamie are joined by Olivia Munn. They discuss Olivia’s breast cancer diagnosis, how she was finally able to shed her armor, why you shouldn’t tell someone going through something to look on the bright side, and more. 


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Veracity - Head to https://VeracityHealth.co and use code MESSY for up to 60% off your order. 

Jones Road - Use code MESSY at https://jonesroadbeauty.com to get a Free Shimmer Face Oil with your first purchase #JonesRoadBeauty #ad


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-03-24
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Carl Radke

This week, Christina and Jamie are joined by Carl Radke, Summer House cast member and  host of "More Life with Carl Radke.” They discuss his journey to sobriety, holding in shame, forgiveness, behind-the-scenes of the show, and more.


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Wildgrain - Wildgrain is offering our listeners $30 off your first box - PLUS free Croissants for life - when you go to https://Wildgrain.com/MESSY to start your subscription today.

Fatty15- Get an additional 15% off their 90-day subscription Starter Kit by going to https://fatty15.com/messy and using code MESSY at checkout.

Jones Road - Use code MESSY at https://jonesroadbeauty.com to get a Free Shimmer Face Oil with your first purchase! #JonesRoadBeauty #ad

Lola Blankets - Get 40% off select Lola Blankets products at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-03-17
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How to Heal Your Relationship With Life

This week, Christina and Jamie are joined by Jamie’s friend Ryan Weiss. They discuss how he helped her through a difficult time, the power of dance, emotional avoidance, why it’s so hard to look inward, and more.

Check out Ryan's course "How to Be Okay When Things Are Not Okay" and use code MESSY at checkout for 10% off


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Lola- Get 40% off select Lola Blankets products at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.

Zoc Doc - Stop putting off those doctors appointments and go to https://Zocdoc.com/MESSY to find and instantly book a doctor you love today. 

One Skin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY #oneskinpod




Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-03-10
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We Don’t Want to Be Defined by This

This week, Christina and Jamie read listener emails and discuss the fragility of life, fighting against your body, and more,


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/MESSY #honeylovepod


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-03-03
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Kelly Ripa

This week, Christina and Jamie are joined by their friend Kelly Ripa. They discuss Kelly's career and how it began at a toy fair, the processing she had to do while writing her own book, the challenges of playing yourself on television, and much more.


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Fatty15 - Get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/MESSY and using code MESSY at checkout.

Lola - Get 40% off select Lola Blankets products at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.

AG1 - For a limited time only, go to https://DRINKAG1.com/MESSY to get a FREE AG1 Flavor Sampler and AGZ Sampler to try all the flavors, plus FREE Vitamin D3+K2 and AG1 Welcome Kit with your first AG1 subscription order! 

Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-02-24
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Stop Talking About It for a Minute

This week, Christina and Jamie read listener emails and discuss skincare products from childhood, crazy animal stories, not thinking too far into the future, and much more. 


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Wildgrain - Wildgrain is offering our listeners $30 off your first box - PLUS free Croissants for life - when you go to Wildgrain.com/MESSY to start your subscription today.

Jones Road - Use code messy at https://jonesroadbeauty.com to get a Free Shimmer Face Oil with your first purchase! #JonesRoadBeauty #ad
Arey - Slow the growth of greys and get 15% off by using code MESSY at https://Arey.com

Cheers - Same night out — way better morning with Cheers. For a limited time our listeners are getting 20% off their entire order by using code MESSY at https://CheersHealth.com  #Cheers #ad

ZocDoc - Stop putting off those doctors appointments and go to https://Zocdoc.com/MESSY to find and instantly book a doctor you love today. 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-02-17
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How You Feel on the Inside Can Be Up to You

This week, Christina and Jamie read listener emails and discuss the Married... with Children reunion, catch up on their TV shows, Jamie opens up about a recent experience, and more.


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Veracity - For up to 45% off your order, head to https://VeracityHealth.co and use code MESSY  


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-02-10
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I Can't Worry About Tomorrow

This week, Christina and Jamie read listener emails and discuss MS fatigue, finding little moments of self care, how to better communicate with friends, and more.


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod

Jones Road - Use code messy at https://jonesroadbeauty.com to get a Free Shimmer Face Oil with your first purchase! #JonesRoadBeauty #ad


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-02-03
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Bobbi Brown

This week, Christina and Jamie are joined by Bobbi Brown. They discuss overcoming obstacles, how to elevate your mood, taking baby steps, and much more.  


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Lola - Get 40% off your entire order at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.

AG1 - Go to https://DRINKAG1.com/MESSY to get their best offer… get a FREE AG1 Flavor Sampler and AGZ Sampler to try all the flavors, plus FREE Vitamin D3+K2 and AG1 Welcome Kit with your first AG1 subscription order! 

Warby Parker - MeSsy listeners get 15% off plus free shipping when they buy two or more pairs of prescription glasses at https://WarbyParker.com/MESSY— using our link helps support the show. #WarbyParker #ad

Fatty15 - Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness -Get an additional 15% off their 90-day subscription Starter Kit at fatty15.com/MESSY and using code MESSY at checkout.



Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-01-27
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I’m a F**king Warrior

This week, Christina and Jamie read listener emails and discuss Jamie’s recent trip, pregnancy and MS, asking for help, and more.


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Wildgrain - Wildgrain is offering our listeners $30 off your first box - PLUS free Croissants for life - when you go to Wildgrain.com/MESSY to start your subscription today.

Veracity - For up to 45% off your order, head to https://VeracityHealth.co and use code MESSY  


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-01-20
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The Impact of Inflammation with Dr. Will Cole

This week, Christina and Jamie are joined by Dr. Will Cole, a functional medicine expert. They discuss how to calm inflammation, medical gaslighting, the interactions between all our systems, and much more.


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at  https://mudwtr.com/messy #mudwtrpod

Grow TherapyWhatever challenges you’re facing, Grow Therapy is here to help. Sessions average about $21 with insurance and some pay as little as $0, depending on their plan.  Visit https://GrowTherapy.com/MESSY today to get started. 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-01-13
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This Is Not Your Fault

This week, Christina and Jamie read listener emails and discuss repeat reality stars, being a mother with MS, not blaming yourself, and more.


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod

Jones Road Beauty - Use code Messy at https://jonesroadbeauty.com to get a Free Cool Gloss with your first purchase! #JonesRoadBeauty #ad


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2026-01-06
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There’s a Lot of Unknown in Life

This week, Christina and Jamie read listener emails and discuss Christmas elves, setting goals, reclaiming your voice, and more.


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

Calm - Calm has an exclusive offer just for listeners of our show – get 40% off a Calm Premium Subscription at https://calm.com/messy

Ridwell - Go to ridwell.com/messy to get $10 off your first pickup or mail-in kit. Because sometimes the best way to do more is just to start with something small that you know makes a difference.

Hexclad - Take advantage of HexClad’s Holiday Sale! Head to hexclad.com/MESSY for Up To 50% Off! #hexcladpartner


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2025-12-30
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Are You Mad At Me? with Meg Josephson

This week, Christina and Jamie are joined by Meg Josephson, author of “Are You Mad at Me?: How to Stop Focusing on What Others Think and Start Living for You.” They discuss the fawn response, how to start healing, the importance of taking a pause, and more. 


Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch


This episode is sponsored by:

ZocDoc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a top-rated doctor today. 
Wild Grain - Wildgrain is offering our listeners $30 off your first box - PLUS free Croissants in every box - when you go to https://Wildgrain.com/MESSY to start your subscription.

iRestore - Unlock your best skin with @iRestorelaser and HUGE savings on the iRestore Illumina Face Mask with code MESSY at https://irestore.com/MESSY #irestorepod

Lola Blankets - Lola BlanketsGet 40% off your entire order at Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

2025-12-16
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