A recovering heroin addict wakes up one morning with an odd sensation on one side of her head: a nagging, constant itch. No matter what she tries, it won?t go away. And eventually it gets so bad? she literally starts to lose her mind.

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?The Sliver?: After a man survives a terrible car accident with only a cracked vertebra, he feels grateful to have emerged relatively unscathed. But after undergoing surgery to fix the problem, his pain only grows worse ? and soon, he?s on the verge of death. And there are only hours left to save him. 

?Killer Style?:  A young man in Turkey leaves his small village for the big city to chase his dreams. But soon, he finds himself so short of breath, he can?t work ? let alone breathe. If he can?t work, he won?t be able to afford to stay. However, as his health gets worse and worse, his job is the least of his worries. 

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When Luigi Mangione allegedly gunned down UnitedHealthcare?s CEO, the media called it a senseless crime. But online, a different story emerged?one of rage, reckoning, and a suspected killer turned folk hero. More than just a true crime podcast, LUIGI, hosted by Jesse Weber, dares to look beyond the crime and the accused to explore a cultural tipping point in America, asking you to decide - is the status quo enough, or is it time for a cultural reckoning?

Listen to Law&Crime?s LUIGI exclusively on Wondery+ and follow the show page to keep up on all the latest developments. You can join Wondery+ in the Wondery App, Spotify, or Apple Podcasts. Visit www.wondery.com/links/luigi and start your free trial now!

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When a high-achieving teenager suddenly starts to freeze up in social situations and her grades plummet, her mother tries to get her help. But doctors can?t explain why the girl is suddenly struggling to do ordinary things like talk. Before long, she?s a shell of herself? and her mother fears that soon there may be nothing left.

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In the town of Oakville, Washington, chaos erupts when mysterious blobs start falling from the sky ? and anyone who touches them ends up in the hospital. As scientists struggle to understand what the blobs are, Oakville?s terrified residents are left to wonder if they?re the victims of a natural disaster? or a targeted attack.

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When an elderly man in New Brunswick, Canada, dies from what seems to be rapid-onset dementia, his doctor believes he had a rare condition called Creutzfeldt-Jakob Disease. But then, dozens of people around the area start experiencing the same awful symptoms, making the doctor fear he?s dealing with something entirely new? and completely terrifying.

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In the 1940s, the people of Donora, Pennsylvania fall prey to a deadly epidemic that destroys their lungs. Doctors suspect it has something to do with the fog that is constantly blanketing their town? but why now? They need to find an answer fast ? before the darkness claims more victims.

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During the COVID pandemic, a boy starts experiencing sudden, inexplicable bursts of pain. At first, his symptoms seem psychological ? but then doctors say he may need brain surgery to fix the problem. That?s when the boy?s mother turns to a cutting edge technology to help her figure out what?s wrong with her son.

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?A Clean Break?

 When a night out in Nepal leaves a tourist weak and hungover, he figures he?ll feel better after some rest and rehydration. But his stomach pain becomes unbearable, and he heads to the hospital. That?s when a doctor discovers a secret that the man didn?t even know he had.

?Look, Don?t Touch?

When dozens of children contract salmonella after visiting the Denver Zoo, doctors assume something there caused the outbreak. But when they investigate further, the answer turns out to be something that was supposed to be impossible.

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For his entire adult life, a successful businessman deals with a bizarre problem: whenever he bends over, he throws up. On top of that, he struggles with asthma-like symptoms. But no matter what techniques he tries or medicine he takes, the man can?t shake his symptoms, sometimes with embarrassing results.

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When a recovering alcoholic nearly dies after falling down his basement stairs, it seems like the tragic result of alcohol withdrawal symptoms. But when he starts seeing people who are not there at his bedside, doctors realize the man has even bigger problems.

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?Just Like the Movies?

A popcorn factory worker comes down with a painful, frightening rash on his arms ? and then, he struggles to breathe. He and his wife are convinced something at his job is triggering these seemingly unconnected symptoms. But nobody believes them? until other workers start getting sick, too.

?Headache from Hell?

When a man in Orlando, Florida begins experiencing severe headaches, he figures it?s the same chronic migraines he?s dealt with for years. But this time, the pain won?t go away, and it turns out he?s dealing with something much more serious ? and more revolting ? than a headache.  

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The parents and grandmother of an infant boy are beside themselves when the baby starts crying, and won?t stop for hours on end. They know something has to be wrong, and they?re skeptical when the doctor says it?s just gas. As the boy weakens by the day, doctors realize that something is putting the baby?s life in danger, but what?

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Following the birth of her second child, a woman comes down with what appears to be a serious case of the flu. Though she gets better, the illness comes back every six months or so, like clockwork. The symptoms get worse over the years, but her doctors are no help, pushing the woman to the limits of her endurance. 

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A heroin user wakes up one morning, feeling strangely stiff. At first, his symptoms are mistaken for drug intoxication. But within days, the man is completely unable to move ? and completely terrified. His doctors realize they?re dealing with something much more serious than a bad trip, but they have no idea what.

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No Reservations:

A Spanish marathon runner develops a mysterious obsession with gourmet food. But what seems like an innocent new passion may be more dangerous than he thinks.

The Game:

After going through her normal morning routine, an otherwise healthy woman finds herself at death?s door. In a mad rush to save the woman?s life, her doctors try to understand why her body is suddenly shutting down with no explanation.

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A couple?s young sons both experience sudden reversals in their physical development, leaving doctors scratching their heads. Nobody understands what?s wrong, because on the surface, the boys seem perfectly fine. But to find the answer, they have to look much deeper.

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A mother is terrified when her five-year-old daughter suddenly develops obsessive compulsive disorder, that leaves her completely unable to eat. Desperate to save her child, the mother embarks on a heart-pounding quest to find an answer before it?s too late.

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In the late 1700s, a doctor in the English countryside battles to save his village from the devastation of smallpox. Then, almost by accident, he stumbles upon a perplexing mystery that helps him revolutionize medicine forever.

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Godmother Knows Best:

 A 15-year-old girl develops mouth sores that are so painful, she can barely eat. Her mother takes her to every doctor imaginable, but nobody knows what?s wrong. Ultimately, the answer doesn?t come from an exam room, but from those who love her the most.

The Game:

A man in Australia has no idea what to do when his young son becomes violent and aggressive. It turns out the boy?s blood is dangerously poisoned? and the cause is something nobody expected.

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After a young man suffers devastating injuries from a tornado, doctors race against the clock to save his life. But the real danger isn?t from his wounds? it?s what?s inside them.

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An ambitious college student has to put her life on hold when she starts experiencing debilitating stomach pain that leaves her dangerously unhealthy. Forced to feed herself through a tube, the young woman wonders if she?ll ever be able to accomplish her dreams, or if she?ll be stuck with this pain forever.

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?Faces Everywhere?

A woman wakes up one morning to find terrifying faces floating above her. No matter how hard she tries to escape them, the faces follow her everywhere. But does the woman need a doctor ? or an exorcism?

?The Perfect Condition?

When an elderly man with emphysema starts to have trouble breathing, it seems like his life is coming to an end. But his wife refuses to give up on him ? and what the doctors find inside the man?s chest is something straight out of an urban legend.

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In the late 1800s, a young man in rural New England comes down with a deadly illness known as ?the White Death.? When his doctor can?t help, the man?s neighbors propose a bizarre treatment? that involves the supernatural.

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When a woman gets sick with a mystery illness during the height of the COVID pandemic, she fears her holiday season will be ruined. But as her entire family starts getting sick one by one, a lousy Christmas is the least of her worries.

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Doctors were sure they could help a man who was suffering from severe swelling in his spine. But nothing worked, and as the man slipped away, doctors could only scratch their heads. They had no way of knowing the problem was far worse than any of them imagined. 

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"Rough Patch"

When a young woman?s skin begins to break out after a wedding, she doesn?t think much of it?at first. But as the rash engulfs her body, she begins to wonder if a person can die from eczema.

"No Warning"

When a skinny teen tries to build some muscle, he ends up white as a sheet and vomiting uncontrollably. As the boy?s condition worsens, doctors wonder if his health kick is to blame. 

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A little girl?s parents grow concerned when she develops a debilitating headache. They take her to the hospital but test after test returns negative. When her doctors finally figure out what?s wrong with her, the answer is something none of them saw coming.

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When a quiet town in Oregon is beset by a dangerous Salmonella outbreak, the health authorities mobilize to trace it back to the source. What they find isn?t just surprising ? it?s sinister.

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When a routine medical study makes patients swell up like sausages, the doctors running it struggle to understand what went wrong. They have to act fast ? because if they can?t figure it out soon, the so-called ?elephant men? could die.

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A college student?s return to school is cut short when she starts acting erratically and has to be committed to a psychiatric hospital. As she continues to spiral out of control, her parents worry that their daughter will never be the same again.

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A teenage girl comes down with unexplainable abdominal pain after spending a few days at a fair. Unbeknownst to her, the same thing is happening to hundreds of teenagers in a completely different state?and doctors can?t figure out what?s causing it.

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An avid runner is out for a routine jog when she suddenly feels dizzy and faints, dropping right in her tracks. Years later, it happens again and doctors warn that she has a serious problem. If she can?t stop it, she?s in danger of passing out and never waking up.

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A single mother is terrified when her little boy becomes violently sick and doctors can?t figure out why. Every test is negative, yet the child seems to be dying. But when the mother finally finds out what?s wrong with him, it?s even more tragic than she ever imagined.

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?The Buried Brain?

A young man barely survives being trapped in an avalanche while on a ski trip. Then, his recovery is derailed when he starts suffering from mysterious seizures. When his doctors find out what?s triggering them, they?re shocked and amazed.

?Killer Jetlag?

A young woman comes home from studying in Ghana, ready to enjoy a relaxing summer. But soon, she starts experiencing horrifying nightmares ? and finds herself on the verge of death.

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A little girl falls prey to a disease so deadly and rare, the CDC fears it might be an act of bioterrorism. Investigators scramble to find the source, but the answer comes from somewhere nobody was expecting.

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A college student in Mississippi has to put his life on hold when his hips literally begin to die. Facing a life of unbearable pain, he must dig deep into his past to find a cure.

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A man vacationing in Germany becomes violently ill, and no medicine is helping. The solution may be hidden somewhere on the man?s home of Vancouver Island? where a deadly outbreak is spreading.

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A teenage boy suffers pain and embarrassment when his leg becomes grotesquely swollen and infected. His doctors can?t stop it from getting worse, and the problem spirals out of control. But his teacher refuses to give up on him. Working together, they make a startling discovery.

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A couple in Colorado is accused of child abuse when their infant daughter is diagnosed with multiple fractures in her legs. The ordeal threatens to break the family apart ? and there may be no putting them back together.

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Seemingly out of nowhere, an otherwise healthy man?s body starts filling with a thick, lemon meringue-like liquid that is slowly drowning him in his own fluids. His family is terrified, both for him, and for themselves ? because this mysterious disease might come for them too.

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One night, two girls from the same school are rushed to the hospital with the same deadly disease. At first, doctors worry the girls? entire school was exposed to the same disease. But soon they realize that the problem is even bigger.

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 In late 1976, a terrifying new disease that causes eyes to bleed grips the country of Zaire. Doctors from all over the world arrive to search for the cure? if one exists at all.

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?A Step Too Far?

A man in Scotland suffering from crippling breathing difficulty is mystified when his doctors can?t figure out what?s wrong with him. As he grows weaker and weaker, he worries that one day he?ll go to bed? and never get up. 

?Dying of Boredom?

After undergoing ankle surgery, an Australian high schooler is dreading a summer stuck inside. But when he suddenly starts struggling for breath, his couch-bound recovery becomes the least of his problems.

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A boy in Minnesota is rushed to the emergency room with one of the worst food poisoning cases the doctors have ever seen. A short while later, a little girl shows up with the same illness. Soon, cases are popping up throughout the state, leaving some on the brink of death as doctors scramble to figure out why. 

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When a young mother?s baby is suddenly hospitalized, doctors accuse her of intentionally harming him. Desperate to prove that she?s innocent, the mother seeks an answer before she loses her son forever.

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In December 1979, young women all over Wisconsin fall ill with a mysterious disease that starts with a bright red rash ? and sometimes leads to death. Soon, it?s happening to women all over the United States ? and nobody knows why.

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A doctor in the early 1900s is tasked with discovering the cause of a sometimes-fatal disease ravaging the American South. But in order to figure it out, he has to conduct a dangerous experiment that puts people?s lives at risk.

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A 9-year-old girl in Hawaii suddenly loses vision in one eye, and nobody knows why. And by the time she gets an answer, it might be too late to save her eye at all.

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?Look Closely?

A teenage boy suddenly falls into critical condition while on vacation with his family in Orlando, Florida. When his doctors find out what?s wrong with him, they fear the worst ? this disease is almost always fatal. In order to save him, they?ll have to act faster than they ever have before.

?Burning From the Inside?

After a young woman crushes her hand in a workplace accident, she begins experiencing debilitating pain throughout her entire body. Will she be able to endure it long enough for her doctors to save her?

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