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Lifespan with Dr. David Sinclair

Lifespan with Dr. David Sinclair

Lifespan with Dr. David Sinclair is a new podcast from world renowned aging research doctor, David Sinclair, Ph.D. Dr. Sinclair is a professor of genetics and co-director of Harvard Medical School's Center for Biology of Aging Research. Topics discussed include the science behind why we age and interventions for slowing and even reversing aging. This podcast is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice.

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Website

lifespanpodcast.com

Episodes

NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4

In this week?s episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters, resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted.

Thank you to our sponsors:

Athletic Greens - https://athleticgreens.com/sinclair Levels - https://levels.link/sinclair InsideTracker - https://insidetracker.com/sinclair

Our Patreon page: https://www.patreon.com/davidsinclair 

Lifespan book: https://amzn.to/3sUqurT

Dr. David Sinclair Social: 

Instagram  Twitter  Facebook 

Matthew LaPlante's Social: 

Twitter

Timestamps:

(00:00:00) Kicking Off Episode Four: Longevity Molecules

(00:02:15) Thanks the Sponsors

(00:04:46) An An Additional Boost Beyond Adversity Mimetics

(00:05:52) Drugs vs. Supplements and Highlight Points

(00:09:54) Longevity Molecules Target the Survival Circuit

(00:11:33) NAD Boosters

(00:13:32) Nicotinamide Riboside

(00:21:26) Nicotinamide Mononucleotide

(00:29:22) NAD Intravenous Drips

(00:32:45) Bioavailability of NAD Boosters

(00:33:40) NAD and Cancer

(00:35:33) Resveratrol

(00:42:26) Red Wine and the French Paradox

(0043:08) Fisetin and Quercetin

(00:47:09) Rapamycin and Rapalogs

(00:49:10) Spermidine

(00:51:27) Metformin

(01:00:27) Berberine

(01:02:43) Dr. Sinclair?s Protocol for Longevity Molecules

(01:08:51) Wrap-up and Next Week?s Episode: Interventions on the Cutting Edge

(01:09:52) Options for Subscription and Support

For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Title Card Photo Credit: Mike Blabac 

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

2022-01-26
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Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3

In Episode 3 of the Lifespan Podcast, Dr. David Sinclair and Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. They begin by highlighting how different types of physical activity (i.e., low-intensity aerobic exercise, high-intensity aerobic exercise, and weight training) protect against age-related disease and enhance longevity. David and Matthew additionally highlight the latest evidence behind hyperbaric oxygen therapy, cold therapy, and heat therapy. As they discuss different adversity mimetics, they also explain how these interventions influence aging at the molecular and physiological levels.

Thank you to our sponsors:

Athletic Greens - https://athleticgreens.com/sinclair  Levels - https://levels.link/sinclair  InsideTracker - https://insidetracker.com/sinclair 

Our Patreon page: 

https://www.patreon.com/davidsinclair

Timestamps:

00:00:000 Introducing Episode 3: Exercise Hot Cold

00:01:01: A Pernicisous Element Called Iron

00:02:46: A Quick Primer on Free Radicals

00:05:42: Review of Dietary Takeaways

00:07:01: Sponsors

00:09:32: Biological Adversity & the Survival Circuit

00:13:24: Survival Sensors (i.e., mTOR, AMPK, and Sirtuins) & Communicators (e.g., Insulin)

00:17:25: Get Off Your Butt

00:19:40: Exercise Protects against Disease & Mortality

00:21:17: Daily Step Count and Walking After Eating

00:22:33: Exercise Activates AMPK and Creates More Mitochondria

00:24:03: Vigorous Exercise, Hypoxia, the Electron Transport Chain

00:28:19: Exercise Increases Glucose Sensitivity and Stimulates Blood Vessel Formation

00:32:13: The Epigenome and Biological Age are Impacted by Exercise

00:36:43: How to Measure your Biological Age

00:37:31: Exercise Recommendations

00:39:28: Wearables and Individualized Health Tracking

00:43:14: The Importance of Weight Training

00:46:08: Physical Activity & Senescent Cells

00:48:01: Wrap-up & Takeaways

00:49:47: Hyperbaric Oxygen Therapy

00:57:24: Cold Therapy

01:03:50: Applying Heat

01:07:04: Adversity Mimetics Produce Endorphins

01:08:07: A Basic Protocol for Mimicking Adversity

01:10:04: Next Week: Molecules & Supplements

01:10:45: Subscription & Support

Links:

A single mutation doubles lifespan in worms Extending lifespan in yeast with one mutation Daily step count and health outcomes Reversing vascular aging in mice Aerobic exercise is linked to a lower biological age A lifestyle and diet intervention decreases biological age An epigenetic clock that predicts time-to-death Ultra-cheap age prediction Exercise decreases biomarkers of cellular senescence Telomere length is increased by hyperbaric oxygen therapy Hyperbaric oxygen therapy improves cognitive performance A cold temperature promotes longevity in worm Sauna bathing, mortality, and cardiovascular risk
2022-01-19
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What to Eat & When to Eat for Longevity | Episode 2

In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. They discuss the science behind how a "low energy state," which can be induced by a period of fasting, combats aging and promotes health. They also walk through research that points to the benefits of a mostly plant-based diet for slowing aging and offer key insights into when to eat and what to eat to maximize longevity.

Sponsors:

Levels - https://levels.link/sinclair Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair

Patreon: https://www.patreon.com/davidsinclair

Timestamps:

0:00:00 Introducing Ep. 2: What to Eat and When to Eat for Longevity

0:01:10 Sponsors

0:04:36 A Starting Place for Longevity: Eat Less Often

0:08:04 Caloric Restriction is an Evolutionarily Conserved Anti-Aging Strategy

0:09:52 Dietary Longevity Strategies are Accessible (and Save Money)

0:11:39 A Low Energy State Triggers a Genetic Pathway Involving Sirtuin Activation

0:13:10 NAD+ is Elevated by a Low Energy State

0:15:23 Fasting, mTOR, and AMPK

0:17:37 Data in Humans vs. Model Organisms

0:21:24 Evidence that Fasting is a Pro-longevity Intervention in Humans

0:24:00 Evidence that Fasting can Attenuate Human Disease

0:25:11 Different Fasting Regimens

0:29:42 Focus on Time-restricted Feeding (? 16 Hours of Fasting)

0:33:26 Continuous Glucose Monitors

0:34:24 Genetics Influence How an Intervention Affects Aging

0:36:51 A Trick for Fasting: Filling your Body with Fluids

0:38:44 Intermittent Fasting with Adequate Nutrition (IFAN)

0:40:00 Things to Avoid: Excess Sugar and Protein

0:45:16 Branched Amino Acids, Red Meat, and mTOR

0:47:53 Plant-Based Diets Protect Against Aging

0:51:44 The Okinawa Diet and Blue Zones

0:54:16 Xenohormesis

0:58:16 Main Takeaways

1:04:12 Obesity, Eating Habits, and Aging

1:05:54 Metabolic Winter Hypothesis

1:06:44 Preview for Ep. 3: Beneficial Stress

1:07:23 Subscription and Support

Links: 

Dietary restriction extends lifespan in dogs  Intermittent fasting in patients with metabolic syndrome  Alternate day fasting in healthy, non-obese humans  Time-restricted feeding in humans with prediabetes  24-hour fast reduces inflammasome activation in humans  Fasting and diabetes  Intermittent energy restriction and multiple sclerosis  Fasting-mimicking diet in patients with breast cancer Mouse genetics influence how diet affects lifespan Vegetarian dietary patterns and human mortality Mediterranean diet slows biological aging Plant polyphenols regulate lifespan in yeast Mediterranean diet is linked to reduced mortality 
2022-01-12
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The Science Behind Why We Age | Episode 1

In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, and how all of this makes up the "Information Theory of Aging", and the difference between "biological age" and "chronological age" and how we can measure biological age through DNA methylation clocks.

Thank you to our sponsors:

Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair

Our Patreon page:

https://www.patreon.com/davidsinclair

Social:

Instagram - https://www.instagram.com/davidsinclairphd Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclairphd

Timestamps:

(00:00:00) Introduction

(00:03:14) Goal of the Lifespan Podcast

(00:07:11) Acknowledgement of Sponsors

(00:10:45) Aging is a Controllable Process that can be Slowed & Reversed

(00:16:42) Organisms with Extreme Longevity

(00:21:47) Genes that Regulate Aging: mTOR, AMPK, Sirtuins

(00:21:55) mTOR & Rapamycin

(00:24:33) AMP-activated protein kinase (AMPK) & Metformin

(00:30:57) Sirtuin Proteins as Epigenetic Regulators of Aging

(00:35:33) Ex-Differentiation

(00:43:30) Measuring Aging - Biological Age vs. Chronological Age

(00:49:30) "No Law That Says We Have To Age"

(00:50:33) Episode Summary & Key Takeaways - Why Do We Age?

(00:54:00) Information Theory of Aging

(00:57:59) Aging is a Medical Condition

(01:01:00) Aging Myths - Telomeres & Antioxidants

(01:01:55) Options for Subscription and Support

Links:

Weapon fragments in bowhead whales  Rapamycin extends lifespan in mice  Targeting Aging with Metformin (TAME) Trial Metformin improves healthspan and lifespan in mice  Metformin reduces all-cause mortality  Reprogramming to restore vision DNA methylation age  Genome-wide methylation profiles & human aging rates  Reversal of epigenetic aging in humans Danish twins study

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

2022-01-05
Link to episode

Welcome to Lifespan with Dr. David Sinclair

Welcome to Lifespan with Dr. David Sinclair.

Dr. David Sinclair is a professor of genetics and co-director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research.

Season 1 will be 8 episodes in total and will launch on Wednesday, January 5, 2022. New episodes will be released every Wednesday morning of both January and February 2022.

This podcast can also be found on YouTube: https://www.youtube.com/davidsinclairpodcast

My goal in creating this podcast is to discuss the science behind why we age and to share the newest research on what we can do to slow, stop and even reverse aging. In doing so, I hope to help explain the science in an easy-to-understand manner and I hope to help all our listeners in their journey to be healthier at any stage of life.

Upcoming episodes will cover: why aging is a disease, the impact of dietary choices, fasting and exercise on aging, how various supplements and prescription drugs can protect against aging, why cosmetic aging occurs and how to combat it, the benefits and advancements of biotracking, and the future of age reversal.

Please subscribe, share with friends, leave a comment or review, and most of all, thank you for coming with us on this journey into the mechanisms of aging and exploration of the tools for living longer, healthier lives!

2021-12-22
Link to episode
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