Top 100 most popular podcasts
Work with Rick Collins
Website: https://www.rickcollins.com/
Instagram: https://www.instagram.com/rickcollinsesq/
Rick Collins joins the podcast to discuss the current legal landscape of peptide research and medical freedom.
We break down the ongoing friction between innovative health practices and regulatory oversight. This conversation is for anyone navigating the complex gray area of modern wellness, focusing on how to stay informed while protecting your right to access emerging protocols. We examine the specific challenges legal experts face when defending these health options in a tightening environment.
Understanding these legal risks is essential for anyone engaged in peptide research. We look at the broader implications for the industry and what the path forward looks like for practitioners and users alike. Whether you are interested in policy or personal health autonomy, this discussion provides a clear look at the reality of the medical freedom movement today.
For research and entertainment purposes only. Subscribe for more peptide research and analysis.👇 ALL MY LINKS IN ONE PLACEhttps://hunterwilliamshealth.com/links
Vilon might be the most underrated peptide I use. If I had to sum it up in one line, it acts like BPC-157 and Thymosin Alpha-1 rolled into one.
In this masterclass I walk through everything I know about it. Vilon is a tiny two-amino-acid peptide from the Khavinson bioregulator family. It works on the thymus, the gland that trains your T-cells. That gland shrinks as we age, and our immune defense slowly fades with it.
Most of the research is cell and animal work out of Russia, plus a few small human trials in diabetics. I’m upfront about that, including one mouse study that raised a cancer question.
Then we get practical. I cover who it’s for and who should skip it. I share my three dosing tiers and how I cycle it. Early fall, right before flu season, is my favorite time to run it. You’ll learn how to reconstitute and inject it, what to stack it with, and what to avoid. I also answer the questions I get asked most.
It won’t feel dramatic in a few days. But for immune support and inflammation over the long haul, I think it deserves a lot more attention.
For research and entertainment purposes only. Subscribe for more peptide research and analysis.
👇 ALL MY LINKS IN ONE PLACEhttps://hunterwilliamshealth.com/links
Over 400,000 of you have used my AI chat app since it went live. I don’t read your individual messages. But the app sends me an anonymized report of what people struggle with most. So I took the top questions from the last week and answered them myself.We start with mitochondria. I walk through how I rotate SS-31, MOTS-c and SLU-PP-332. I also explain why I think a lot of people who stall on a GLP-1 have a mitochondrial problem. Then we hit reconstitution math, cloudy vials, and why some peptides sting.From there it’s growth hormone. Tesamorelin alone versus the tesamorelin and ipamorelin blend, plus what to do when it wrecks your sleep. On the GLP side I cover how I raise my retatrutide dose and use taurine for the heart rate bump. Then how I step down without the appetite rebound.We also get into where to inject BPC-157, my actual favorite sleep peptides, and free versus total testosterone. Plus the hormone targets I like for women in perimenopause.I close with fertility. After years on TRT, I went from zero sperm to the top of the reference range in nine months. I walk through the exact stack I used. Your questions, my honest answers.For research and entertainment purposes only. Subscribe for more peptide research and analysis.👇 ALL MY LINKS IN ONE PLACEhttps://hunterwilliamshealth.com/links00:00 Intro and where these questions come from04:26 Stacking SS-31, MOTS-c and SLU-PP-33206:03 SS-31 fasted or with food06:33 Where 5-amino-1MQ fits with TRT07:18 NAD and 5-amino in one syringe07:41 Can Cartalax help bone on bone08:34 LL-37 with CJC or MOTS-c09:01 Reconstituting KLOW and GLOW blends10:00 Cloudy vial, is it ruined10:39 Best syringes and needles11:22 Why some peptides sting12:21 Tesamorelin alone vs tesa/ipa blend14:28 Tesamorelin timing and sleep15:06 Tesamorelin to CJC and ipamorelin15:39 Ipamorelin 5 on, 2 off16:08 HGH and IGF-1 LR3 timing17:37 Protecting muscle off a GLP-118:37 How to titrate GLP-3 RT19:51 GLP-3 RT heart rate bump20:48 GLP-3 RT back to GLP-2 TZ22:00 Stepping down off a GLP-123:36 Eloralintide, amylin and GLP-1s24:52 GLP-3 RT side effects and breaks25:32 Where to inject BPC-15726:34 How long to run KLOW27:30 KPV before BPC-157 and TB-50028:08 BPC-157 and TB-500 in one syringe28:21 Favorite sleep peptides and DSIP29:34 When Semax does nothing30:08 Calming inflammation without growth30:57 Free vs total testosterone31:24 Restarting natural testosterone31:44 Testosterone injections vs cream32:45 Testosterone targets in perimenopause33:54 PT-141 and women's libido34:34 Labs to get and how often35:47 Kisspeptin, enclomiphene and HCG for fertility36:50 Wrap up
Most people know oxytocin as the love hormone. That’s only a small part of the story.In this masterclass I break down what I’ve learned using oxytocin myself and digging through 70 years of human data. It was the first peptide hormone ever made in a lab.
It’s still an FDA-approved drug today.Oxytocin works like a volume knob. It amplifies whatever state you’re already in. A safe setting means deeper connection. A stressful setting can mean more anxiety.We cover how it works in the brain and body, who it’s actually for, and who should skip it. I walk through dosing in micrograms and IUs, nasal spray versus injection, and the mixing mistake that has people taking five to ten times too much.I also get into the uses nobody talks about.
Cutting 120 to 150 calories at a hard meal without the nausea of a GLP-1. Post-workout dosing for muscle recovery. Getting things moving when a GLP-1 slows your gut.Plus why every other day beats daily dosing, how I stack it with PT-141, and the trick I use to make cardio feel rewarding.If you’ve been curious about oxytocin, start here.
For research and entertainment purposes only. Subscribe for more peptide research and analysis.
👇 ALL MY LINKS IN ONE PLACEhttps://hunterwilliamshealth.com/links
Samantha Lander is one of the most compelling voices in functional health and peptide coaching, and her path to getting here is unlike anyone else in the space.
She’s a functional diagnostic nutritionist who went from addiction, federal prison, and a money laundering charge to building one of the most effective coaching practices for people who’ve tried everything and still can’t get results.
She works primarily with perimenopausal women and complex cases, the clients who’ve been to every doctor, run every lab, and still feel stuck. Her approach starts with the gut, the hormones, and the trauma history before a single peptide enters the conversation.We get into her full origin story, why your gut has to be addressed before you touch a GLP-1, the SIBO connection most coaches are missing, how to actually test estrogen (all three, not just one), and the AOD and five amino 1MQ combinations that are quietly doing more than the headline peptides.
We also talk about MCAS protocols, what to do when patients react to everything, and why sitting in your discomfort sober is still the most powerful biohack.This one goes places most episodes don’t. Stay until the end.
Connect with Samantha Lander:
Website: https://seefitliving.seefitpt.com/about-me
Instagram: https://www.instagram.com/seefitliving/
👇 ALL MY LINKS IN ONE PLACE
https://hunterwilliamshealth.com/links
⚠️ This podcast is for research and educational purposes only. Nothing discussed here constitutes medical advice. Always consult a licensed healthcare professional before making any changes to your health protocol. ⚠️
Most people treat IGF-1 LR3 like a muscle peptide you just add to the cart. I want to slow that down a bit.In this masterclass I break down IGF-1 LR3 and IGF-1 DES. Both are modified versions of the IGF-1 your liver makes. They work by dodging the binding proteins that keep most of your IGF-1 parked and inactive. More free IGF-1 means more signal actually reaching the muscle.I cover who these make sense for and who should skip them. I walk through my dosing tiers, starting at 40 to 50 micrograms. We get into timing around training, why you always dose with carbs on board, and the day my wife and I ended up buying candy mid-workout.I also explain why your IGF-1 blood work might drop while you run these. Plus the feedback loop behind it, why I cycle four to six weeks, and how I stack them with TRT and growth hormone.One honest note. There are zero human trials on either compound. Most of the data comes from rats and cell cultures, and the rest is experience, mine included.Done right, these are a five to ten percent edge on top of a solid foundation. That’s it, and that’s still worth having.For research and entertainment purposes only. Subscribe for more peptide research and analysis.👇 ALL MY LINKS IN ONE PLACEhttps://hunterwilliamshealth.com/links
Dr. Tyna Moore is one of the most censored voices in the peptide and HRT space. She’s a naturopathic doctor with decades of clinical experience in regenerative medicine and was one of the first practitioners advocating for intelligent, individualized use of GLP-1s before it was mainstream. Instagram silenced her in 2024 right as the conversation was heating up. Today she’s here to set the record straight.
We get into the origins of GLP-1 micro dosing, the LDN analogy that actually explains it, how censorship twisted her message into a vanity weight loss narrative, and why she believes GLPs are one of the greatest longevity tools we have. We also cover HRT for perimenopausal women, retatrutide, injectable joint therapies, and things that have never been discussed publicly before.
Topics covered: GLP-1 micro dosing explained, LDN vs GLP-1 mechanism, how censorship shaped the narrative, canc3r and COVID data, retatrutide for perimenopausal women, HRT before or after GLP, the 35% weight loss study, joint health and when BPC-157 stops working, prolotherapy and PRP, tachyphylaxis and the blast and cruise model, estrogen receptors in the brain, and what your partner’s TRT could be doing to your hormones.
Connect with Dr. Tyna Moore:
Website: drtyna.com
Community: skool.com/drtyna
Instagram: instagram.com/drtyna
Connect with Hunter:
hunterwilliamshealth.com/links
⚠️ This podcast is for research and educational purposes only. Nothing discussed constitutes medical advice. Always consult a licensed healthcare professional before making any changes to your health protocol.
P21 is one of my favorite brain peptides. It's also one of the least talked about.In this masterclass I break down everything I know about it. That includes the mechanism, the research, and how I actually use it.Here's the honest part up front. There is zero published human data on P21.
Everything we have comes from cell and animal studies. The dosing I share is built from my own experience and what I've seen with clients.
So why do I care about it? P21 is a small synthetic peptide built from CNTF, a protein that helps neurons survive. In animals it raises BDNF, which is basically fertilizer for your brain. It also grew new neurons in the memory center, rebuilt synapses, and reduced tau tangles in Alzheimer's models.I played a lot of football and took a lot of hits.
Concussion recovery is personal for me, and P21 is a big part of how I approach it.I also cover who should skip it, my three dosing tiers, cycling, reconstitution, and how it stacks up against Cerebrolysin, Semax, and Dihexa.
Just don't expect Limitless. P21 is a slow brain tune-up, and that's exactly why I like it.For research and entertainment purposes only.
Subscribe for more peptide research and analysis.
👇 ALL MY LINKS IN ONE PLACE: https://hunterwilliamshealth.com/links
Glutathione is the most boring compound I use. It's also one I'd put in my top five peptides.Your cells make it every day. It's your main internal antioxidant, the buffer that soaks up the damaging byproducts of making energy. Levels drop with age, alcohol, illness and hard training.
When that tank runs low, a lot of other therapies stop working as well.In this masterclass I break down redox in plain English. Then I cover who actually benefits and who can probably skip it. I walk through every delivery route and what the human data shows for each. Plain oral does a little. Liposomal does a lot more.I share my three dosing tiers, how I think about cycling, and why I keep injections away from the hours after training. We get into reconstitution, the taurine trick for injection sting, and storage. I also talk about the transdermal version I've been testing.
That one is anecdote only, with no controlled human data yet.Plus why I pair it with mitochondrial peptides, and why toxic burden may be behind a lot of stalled GLP-1 results.If your protocol has plateaued and you can't figure out why, start here.
👇 ALL MY LINKS IN ONE PLACEhttps://hunterwilliamshealth.com/links
Most peptides get knocked for having no human trials.
ARA-290 is one of the few that does. Randomized, placebo-controlled studies show it regrowing small nerve fibers.In this masterclass I walk through where it came from. It was built out of EPO, the kidney hormone made famous by blood doping. The researchers kept the tissue repair side and left out the red blood cell side.
So no rise in hematocrit, which is how thick your blood runs, and no added clotting risk.I cover who this is for. Mainly diabetic neuropathy, small fiber neuropathy from sarcoidosis, and unexplained burning nerve pain.
I also cover who should skip it. If a herniated disc is pressing on a nerve, this won't decompress anything.Then we get practical. The 2017 trial found 4 mg a day beat both 1 mg and 8 mg. I go through cycling, week by week expectations, and why I'd run it before BPC-157 and TB-500. I explain why some vials gel up and how phosphate-buffered saline fixes it.The limits are in here too.
The longest trial ran twelve weeks. The long COVID use is anecdotal only.I don't use it myself. I don't have neuropathy. But if nerve pain is your problem, this one can be a godsend.
For research and entertainment purposes only. Subscribe for more peptide research and analysis.
👇 ALL MY LINKS IN ONE PLACE
Most people have never heard of Cartalax. I think it's the peptide that gets healing done when BPC-157 and TB-500 stall out.This is the full masterclass. Cartalax is a three amino acid bioregulator from the Khavinson group in Russia. BPC and TB-500 work on growth factors at the cell surface. Cartalax goes inside the nucleus and changes which genes cartilage cells express. In cell culture it roughly doubled chondrocyte growth and raised SIRT1 and SIRT6, two longevity proteins that drop in arthritic joints. Human data is thin, so I'm clear about where the research ends and my experience begins.I cover why cartilage is so hard to heal, how Cartalax fits next to BPC, TB-500, GHK and KPV, my three dosing tiers from maintenance up to 2mg a day, dosing by goal, cycling logic, reconstitution, where to inject, and the full healing stack people are now calling Wolverine Plus. Plus troubleshooting, contraindications, and the FAQ on capsules, drug testing, bone on bone, and spine issues.There's also the story of how I found it, injecting one sore wrist and comparing it to the other.If you've stalled on the standard healing peptides, this one is for you.For research and entertainment purposes only. Subscribe for more peptide research and analysis.👇 ALL MY LINKS IN ONE PLACEhttps://hunterwilliamshealth.com/links
LL-37 is the peptide I think everyone should have on hand and almost nobody should be taking every day.
It's the only cathelicidin in the human body. That's an antimicrobial peptide your immune system makes to punch holes in bacteria, break up biofilms, and neutralize endotoxins. In this masterclass I walk through how it works. I cover why your vitamin D level decides whether your body can even make it. Then the specific situations where I reach for it. Stubborn sinus infections, bacterial acne, gut biofilms, suspected mold, and high-exposure travel windows.
I also cover who needs to stay away from it. Active autoimmune flares, rosacea, certain cancers, and mast cell issues can all go the wrong direction with LL-37.
Then dosing. I break down why I use 100 to 150mcg instead of the 2mg some people push. I go over how long a cycle should run and why maintenance dosing makes no sense. And I show how I sequence it with Thymosin Alpha 1, BPC-157, and TB-500.
One honest note. Almost all of the LL-37 data is preclinical or anecdotal. The only human trial is topical, and the lower doses beat the higher ones.
If you've ever wondered whether LL-37 belongs in your protocol, this one answers it.
For research and entertainment purposes only. Subscribe for more peptide research and analysis.
👇 ALL MY LINKS IN ONE PLACE
https://hunterwilliamshealth.com/links
We cover what color puncture actually is and the science behind it, how it works on the prefrontal cortex, why emotional trauma has the same cellular imprint as physical injury, what sovereignty actually means and why most people have given theirs away, how color helped Taylor heal plantar fasciitis that peptides and hormones could not touch, the GLP and anhedonia story that stopped me in my tracks, why your partner is not supposed to fill everything, and a lot more.This one goes deep. Not just on peptides but on what it actually means to know yourself.For research and entertainment purposes only.
⚠️ For research and entertainment purposes only.
⚠️👇 ALL MY LINKS IN ONE PLACE: https://hunterwilliamshealth.com/links
Connect with Yvonne:
Website: https://soulvessels.com/
Instagram: https://www.instagram.com/soulvessels
NAD+ is not a peptide. That one fact changes how you should use it.Peptides send a signal. NAD+ is a coenzyme, meaning it does the work itself. There is no receptor to downregulate, so the cycling logic is completely different.In this one I walk through what NAD+ actually does inside the cell, what burns through it, and whether it really crashes with age. The decline is real. It is just far more modest and tissue specific than the biohacking world tells you. Skin drops hard. Brain drops 10 to 13 percent across a lifetime. Liver and muscle barely move at all.I also get into the uncomfortable part. Injected NAD+ probably does not enter your cells intact. Surface enzymes break it down first, which means you may be paying a lot to deliver precursors.Then we cover dosing tiers, subQ versus IM, cycling blocks, methylation, what to track, and the 5-Amino-1MQ combo I run at much lower doses.I am not an NAD+ expert and I say so upfront. This is my lens on where it fits and where it does not.Fix your foundations first. Then decide if you actually need it.⚠️ For research and entertainment purposes only. ⚠️👇 ALL MY LINKS IN ONE PLACE https://hunterwilliamshealth.com/links
Han Sijmons flew in from Holland to sit down with Taylor and me and we just let it rip. Hans is a nurse, an EMT, and one of the most genuinely knowledgeable people I have met in this space. He came up through the same world as Alex Kikel and has been quietly coaching and optimizing people in Europe for years.We covered a lot of ground. His journey starting TRT in Holland as a younger guy and fighting the medical system to get taken seriously. The EMT and nurse peptide stack he built for high stress shift work. How he got his fertility back twice while on testosterone and what that protocol actually looked like. The KY19382 hair serum that outperformed a hair transplant in 14 weeks. Why finasteride is the number one inhibitor of sexual function out of the 600 most prescribed drugs. The GLP and hydration problem nobody is talking about. And a lot more.This was a really fun one. Han is the real deal.
👇 ALL MY LINKS IN ONE PLACEhttps://hunterwilliamshealth.com/links
Connect with Han:
Instagram: https://www.instagram.com/arcanumcoaching
YouTube: https://www.youtube.com/@Arcanum-Health
Website: https://www.arcanum.health
⚠️ For research and entertainment purposes only. ⚠️
If you already ran BPC-157 and TB-500 and still have a nagging injury, this one is for you.
MGF stands for mechano growth factor. It is a 24 amino acid fragment of IGF-1. That is the growth factor your body makes in response to training and damage. It came out of the bodybuilding world as a site injection peptide. That never panned out.
What it actually does is more interesting to me. It does not raise your IGF-1 levels. It seems to make your tissue more sensitive to the IGF-1 you already have. More bang for your buck out of what is already there.
I want to be straight about the evidence. Novartis and GlaxoSmithKline both tried to reproduce the original findings and failed. Human data is thin. Most of what we have is animal work on bone healing, cardiac recovery, and tissue quality.
I cover what MGF is and how PEG-MGF differs. Dosing tiers, cycling, injection technique, and troubleshooting. Plus how to stack it with BPC-157, TB-500, GHK, and growth hormone peptides.
Think of this one as a supporting actor. It makes everything else you are doing work better. It is not going to grow your glutes on its own.
⚠️ For research and entertainment purposes only. ⚠️
👇 ALL MY LINKS IN ONE PLACE https://hunterwilliamshealth.com/links
Stephanie Gambetta flew out to North Carolina and sat down with Taylor and me for what ended up being one of the most honest conversations I have had about the peptide space.Stephanie runs Loop Health and has probably worked with more perimenopausal and menopausal women on peptides and GLPs than anyone in the country. She has the boots on the ground data that most people in this space do not have access to.We cover the biggest mistakes people are making right now, why women in their 40s and 50s are being thrown on GLPs before their hormones are even checked, the Adderall connection that nobody talks about, peptides in college culture and what parents need to know, the wild west of the research peptide industry, TFA versus acetate salt and why almost nobody selling peptides knows what that means, the SIBO and GLP connection, and where all of this is heading.Taylor jumps in throughout and this one covers a lot of ground.⚠️ For research and entertainment purposes only. ⚠️👇 ALL MY LINKS IN ONE PLACEhttps://hunterwilliamshealth.com/linksExplore the Loop ecosystem and join the community: https://loop.health/stephaniegambettaConnect with Stephanie:https://www.stephaniegambetta.comhttps://www.instagram.com/stephanie_gambettahttps://www.instagram.com/loop.way
All Links Here: https://hunterwilliamshealth.com/links
Epitalon might be the most requested masterclass I have done. It might also be the most misunderstood peptide out there.
Most people run 5 to 10 milligrams a day because that number is everywhere online. I dig into where it actually came from, and it is not where you think. Those doses were built around epithalamin, the crude pineal extract from cow glands. Epitalon is the synthetic four amino acid version. They are not the same thing.
I walk through the pineal gland and why melatonin production falls off with age. I cover how Epitalon seems to skip the usual receptor route and go straight into the cell nucleus. That is the proposed mechanism behind the clock gene and telomerase effects.
I also cover the telomere data honestly. The 2025 work is in vitro, meaning cells in a dish, not people.
Then we get practical. My three dosing tiers. Cycling logic. How to sequence it with growth hormone peptides, DSIP, Thymalin, and Pinealon. Reconstitution, oral, and intranasal. Troubleshooting for the people who feel nothing, and the people who end up wired at night.
Plus the cancer question, which deserves a straight answer instead of a dodge.
All Links Here: https://hunterwilliamshealth.com/links
Melanotan 1 and Melanotan 2 are the two peptides people ask me about every summer. So I put together the full masterclass on both.
I combined them because you cannot really talk about one without the other. They came out of the same research program at the University of Arizona. But they hit different receptors, and that changes everything about how you use them.
We get into how the melanocortin system works and why sunlight is still required. I walk through the eumelanin shift, which is the pigment that actually protects you. Melanotan 1 is FDA approved for a rare light sensitivity condition. Melanotan 2 has three small studies from the 90s and a lot of gray market use.
I cover my dosing tiers, dosing by skin type, cycling patterns, and how to time a cycle around a beach trip or a wedding. I also cover what to stack it with and what to never run alongside. Then the side effects nobody warns you about. Nausea, flushing, darkening moles, and priapism are all real.
I talk honestly about the skin cancer question. Nobody knows for sure, and I say that.
My verdict is at the end. For most people it is not the one they expect.
CJC-1295 is one of the most purchased peptides in the research space. It is also one of the least understood.Most people pick it up because a friend told them to. Then they run into side effects nobody warned them about. Around 70% get injection site reactions. Plenty get flushing, hives, or headaches. That does not make it a bad peptide. It just means you should know what you are walking into.In this one I cover both versions, DAC and no DAC, and where I land on each. We get into how GHRH analogs signal the pituitary to release growth hormone. I explain the four amino acid swaps and why they matter. We also talk about the halted 2006 trial and the death that still follows this compound around.Then we get practical. Dosing tiers, why fasting is not optional here, cycle length, and the order I would introduce ipamorelin. I also cover who should skip CJC entirely and what to track while you run it.Human data on CJC is thin compared to tesamorelin. I say so where it matters.If you are running it already or thinking about it, this is the full picture.⚠️ For research and entertainment purposes only. ⚠️👇 ALL MY LINKS IN ONE PLACE https://hunterwilliamshealth.com/links
Most people I talk to are doing everything right with peptides and hormones and still have a layer they have never touched.
I brought Brandon Amalani on for exactly that reason. He has spent over 20 years at the intersection of traditional Chinese medicine, Japanese herbal systems, EMF research, and electrotherapy. He built his own PEMF device from scratch because nothing on the market met his standards. He runs Shen Blossom, one of the most respected small batch Japanese herbal operations in the country, and works with Blushield, which focuses on EMF protection.
In this episode we go deep on the layer most people in the peptide world are completely ignoring. How your cells act like radio antennas. Why voltage gated calcium channels matter more than most people realize. What terrain theory actually means and why it changes everything. The three tier EMF protection system Brandon uses. And why electrotherapy might be the most underrated recovery and optimization tool available right now.
We also get into why herbs act like load balancers for the body, why peptides are software running on hardware that has to be primed first, and why the most disciplined people in history never needed any of this and still outperformed almost everyone.
Brandon closes with a live demo of the Arc device.
For research and entertainment purposes only.
Follow Brandon:
Blushield (code HUNTERW for a discount): https://www.blushield.com/
Shen Blossom: https://shenblossom.com/
All my links: https://hunterwilliamshealth.com/links
All Links Here: https://hunterwilliamshealth.com/links
Most people take DSIP expecting a peptide version of Ambien. That's why they end up writing it off.
DSIP won't knock you out. It won't help you fall asleep either. What it does is normalize the structure of your sleep once it starts. It also turns down the volume on your stress axis.
In this masterclass I walk through all of it. What DSIP actually is. The rabbit experiment in Basel that led to its discovery. And the strange fact that 50 years in, nobody has found its receptor.
I get into the dosing tiers and why 100 to 200 micrograms leaves most people feeling nothing. I cover timing and the 30 minute half-life. And why this needs a week or two of consecutive nights before results show up.
We also cover stacking. Epitalon for the timing signal, GH secretagogues, SS-31, and the bioregulators. Plus what I would stay away from.
Then troubleshooting and a full FAQ. Legality, growth hormone, the old withdrawal trials, side effects, and whether cycling is worth it.
Fair warning. The human data here is old and thin. I am honest about that throughout, including where we only have rodent work.
Run it right and DSIP earns its place quietly.
All Links Here: https://hunterwilliamshealth.com/links
Most people file GHK-Cu under skin and beauty. That sells it short.
This little three amino acid peptide shifts around 4,000 human genes toward repair. It delivers copper to the enzymes that rebuild collagen and power your cells. Your body makes it, and you lose about 80% of it by age 60.
In this masterclass I cover what it actually does and how to use it. We get into who it's a good fit for and who should skip it. I break down dosing by goal, the timeline for results, and whether to cycle it.
I walk through the Glow stack with BPC and TB-500. I cover why sequencing matters and how to reconstitute it so it stings less. Yes, it should turn blue. I explain why that matters.
I'm honest about the gaps. A lot of the gene data is cell culture work. The cognitive and lung findings come from animal studies. I tell you where the human evidence is strong and where it isn't.
We also hit the copper uglies, injection reactions, and the FAQ I get asked most. By the end you'll know if GHK-Cu belongs in your rotation.
All Links Here: https://hunterwilliamshealth.com/links
Ipamorelin might be the best peptide to start with if you have never touched growth hormone.
In this masterclass I break down why. It pushes out your own growth hormone without dragging cortisol, prolactin, or hunger along with it. That clean profile is the whole reason it is still around.
I go through what it actually does in the body. It starts at the ghrelin receptor and ends with IGF-1, which carries the real benefits. Better sleep, better recovery, better skin and hair over time.
I cover who this is for. Anyone over 35, and especially women in their 40s and 50s who have never tried a growth hormone peptide.
Then I get practical. Dosing tiers, the threshold where more stops helping, and how to cycle it. Plus how to stack it with CJC-1295 NoDAC the right way. I also explain why I have people run ipamorelin alone before adding anything.
If you are on a GLP-1, this pairs really well and helps protect your muscle.
We do not have a mountain of human trial data here. I am honest about that. But the safety record is mature and the anecdotal results are strong.
If you are curious about growth hormone, start here.
All links here:https://hunterwilliamshealth.com/links
In this masterclass I break down TA-1 from the ground up. It works like a thermostat for your immune system. It turns a weak response up and pulls an overactive one back toward the middle.
One thing up front. You will not feel this peptide when you inject it. That is normal. It works slowly over weeks.
I cover who this peptide is really for. Older adults with fading immunity. People stuck in post-viral limbo after COVID or Epstein-Barr. Anyone who travels hard and gets run down.
I also cover who should skip it, including severe autoimmune flares.
We get into dosing tiers, timing, and why more than two milligrams does nothing. I walk through cycling, stacking with LL-37 and KPV, reconstitution, and how to tell it's actually working.
I stay honest about the evidence. TA-1 is the most documented immune peptide we have. It also has real limits, and I flag where the human data runs out.
This is the one I never travel without. Not because it feels like anything. Because I would rather have it and not need it.
Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/links
In this masterclass I break down what MOTS-c actually is. It's a tiny peptide your mitochondria make when you exercise. It's the only major peptide coded inside the mitochondrial genome, not the cell nucleus.
I get into how it flips the AMPK switch, your cell's main fuel gauge. I cover the dual action that lets it travel into the nucleus and turn on antioxidant genes. That part makes it pretty unique.
Then I walk through the practical stuff. Who's a good candidate and who should skip it. My full dosing tiers, from a 250mcg screening dose up to 5mg. Cycling, reconstitution, and how I pair it with SS-31 and humanin.
I also cover the side effect nobody warns you about. Around 10% of people react badly, and some of those reactions are serious. That's why I start low and work up slowly.
A heads up on the evidence. Most of the exciting data is still animal models. Human data is thin, so I flag where I'm extrapolating.
MOTS-c is more bioactive than its reputation suggests. Treat it with respect and it rewards you.
Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/links
BPC-157 is the peptide almost everyone starts with. In this masterclass I walk through why, and where the hype gets ahead of the evidence.
We have about 30 years of animal studies on this one. We have fewer than 30 human subjects in published research. I keep that line clear the whole way through.
I cover what BPC actually does. It helps the body repair tissue. It works on the gut, tendons, ligaments, and even the brain in animal models. It is not a steroid and it does not build muscle on its own. I explain how it works, who it helps, and who should skip it.
Then we get practical. Dosing tiers, how to reconstitute the vial, how to inject near an injury, and how long before you feel anything.
I tackle the cancer question head on. The fear is plausible on paper. The data does not really back it up. I tell you exactly where I land.
We also cover cycling, the Wolverine stack with TB-500, oral versus injectable, and the FDA shift happening right now.
Even if you already know this one, you will probably pick up something. If you are new to peptides, start here.
Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/links
Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/links
KPV is the most underrated peptide out there. Almost nobody talks about it. In my opinion it should be one of the most demanded peptides we have. If I had to choose, I'd take it over BPC and TB-500 every single time.Here's why. KPV is a tiny three amino acid fragment of alpha-MSH. It directly blocks NF-kappa B, the master switch your body uses to turn inflammation on. Most peptides work around the edges. KPV shuts the alarm off at the door.In this one I cover all of it. What KPV is and how it works. Who actually benefits. Dosing by tier and by purpose. How to stack it with BPC, TB-500, LL-37, and your GLP-1. What to track on bloodwork. Cycling, sequencing, troubleshooting, and a full FAQ.If you've ever run a protocol that worked and then stalled out, this one is for you. Inflammation is almost always the rate-limiting step in healing.Make sure you're on the email list. And come join us in the Axion Collective for live coaching every Thursday.⚠️ For research and entertainment purposes only. ⚠️
Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/links
Tesamorelin is one of the few peptides I've seen actually move the needle on body composition. So I made a full masterclass on it.
This is the user's guide as it stands in 2026. I cover what tesamorelin is, how it works, and the best practices I'd recommend for using it.
We get into the growth hormone axis and why a GHRH is different from a GHRP. I break down the clinical data, the 15% visceral fat reduction, the liver fat numbers, and the cognition research almost nobody talks about.
Then we get practical. Dosing, timing, fasted injections, and the cycling patterns I actually use. I share why I stay at one milligram instead of two and what the water retention tradeoff looks like at higher doses.
I also cover stacking with testosterone and GLP-1s, reconstitution, injection technique, side effects, and the people who should skip this one entirely.
I'm honest about the limits too. Some of this evidence is strong and some of it isn't. I tell you which is which.
If you're thinking about tesamorelin or already using it, this is everything I'd want you to know.
Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/links
Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/links
TB-500 spends way too much time in BPC-157's shadow. I wanted to fix that.
This is my full TB-500 masterclass. I go deep on what this peptide actually does, and why it works so differently than BPC even though we lump them together as the Wolverine stack.
First I clear up the confusion between TB-500 and thymosin beta-4, because most people have no idea what they're actually buying. Then I break down the mechanism in plain language. Think of TB-500 as the foreman on a job site, moving the right materials to the right injury at the right time.
I cover who it's for, who should skip it, and my full dosing tiers from general recovery up to severe injury. We get into cycling, reconstitution, injection technique, and how to stack it with BPC, GHK, and the growth hormone peptides.
I also answer the big questions. Is it legal? Will it cause cancer? Will it touch your hormones? Does it grow hair?
If you want more from me, get on the email list and check out the Axion Collective. Both links are in my bio.
Enjoy this one. I love TB-500.
Taylor and I are back for another Reader Mailbag. This one covers a lot of ground.
We start with anhedonia on GLP-1s because the questions on this have been nonstop. People are experiencing it on Semaglutide, Tirzepatide, and Retatrutide and we break down why it happens, whether it is dose related, and what you can actually do about it.
From there we get into the Reta and heart rate debate, Taylor's GLP rotation strategy, and whether the cardiovascular tradeoffs are actually worth worrying about.
Then Taylor takes over for the hormone optimization section for young women in their twenties and thirties. Her personal story on this one is worth watching alone.
We also cover accidental peptide overdoses, what to do when it happens, and finish with teen acne solutions using peptides and topicals.
Submit your questions for the next episode at the link below.
For research and entertainment purposes only.
Links, cheatsheet, private group and more 👇https://hunterwilliamshealth.com/links
Hey everybody, this is the May 2026 Q&A video, and we made it through a packed hour of your questions. I had so many submitted that I had to print them off and group them by category to get through them all.
All My Links Here: https://hunterwilliamshealth.com/links
We cover a lot of ground. GLPs and fertility, hunger on retatrutide, dopamine differences between Sema, Tirz, and Retta, GLP side effects and how to manage them. Then we move into hormones and HRT, including the right starting dose of testosterone, kisspeptin for fertility, progesterone dosing for women, and why so many doctors are starting guys way too low.
From there we get into GH peptides and IGF cycling, my full injury healing stack, autoimmune protocols, cognitive stacks for studying, cosmetic questions, heart health, bone density, thyroid, and a long miscellaneous section covering rapamycin, MOTS-c, prostate peptides, traveling with peptides, and more.
I also share the new AI chat tool I built that is trained only on my content. It is at chat.hunterwilliamshealth.com if you want to play with it.
Thanks for submitting these. Keep them coming. See you in June.
⚠️ For research and entertainment purposes only. ⚠️
All links here: https://hunterwilliamshealth.com/links
SS-31 continues to be one of my favorite peptides of all time, and the more data that comes out on it, the more I think every person over 25 has a use case for it.
In this masterclass, I'm breaking down everything I know about SS-31. We cover what it actually does at the cellular level, why it's the first FDA-approved mitochondrial peptide, and why it works differently than almost every other peptide out there. No receptor binding. It goes inside your cells, binds to cardiolipin, and stabilizes the structure of your mitochondria.
I walk through the three dosing tiers I use with people, my take on cycling, why I run SS-31 before MOTS-c, how to stack it with GLPs, GH peptides, and the healing peptides, and what to actually track when you're on it. I also cover the troubleshooting stuff people ask me about constantly. Why don't I feel anything? Should I cycle? What about the headaches in the first two weeks?
If you're a clinician or just researching for yourself, this is the complete user's guide.
For entertainment purposes only.
Timestamps
00:00 Intro
01:00 What this masterclass covers
03:18 Why SS-31 matters and what makes it different
03:46 FDA approval and the Forzenity brand name
04:50 Peptide foundations and how SS-31 is made
05:52 The SS-31 sequence and the Seto-Schiller naming origin
06:40 Mitochondria 101 and why ATP matters
07:28 Mitochondrial dysfunction across chronic disease
08:34 Cardiolipin, cristae, and Barth syndrome
09:34 Why SS-31 is not a direct antioxidant
10:46 How SS-31 actually works (the upstream Godfather effect)
11:12 Why no receptor means no desensitization
13:36 Who SS-31 is for (mid-30s, athletes, post-illness, metabolic dysfunction)
14:24 Who should skip it
15:34 The three-tier dosing ladder
16:54 The FDA-approved 40mg dose and diminishing returns
19:08 Dosing by goal (longevity, performance, recovery, healing)
19:48 Cycling logic and the 8-12 week framework
20:22 When to dose (morning vs night)
21:24 What to expect and when (week-by-week timeline)
22:20 Why cycle if it doesn't desensitize
24:24 SS-31 before MOTS-c (the structural engineer vs operations manager)
26:18 Reconstitution and injection technique
28:22 What to track (subjective markers and biomarkers)
29:18 Stacking with MOTS-c, Humanin, BPC, GH peptides, and GLPs
31:28 Stacking for cognition and visceral fat
32:26 Troubleshooting "I don't feel anything"
33:54 Injection site reactions
34:36 When to discontinue and the first-two-week headache window
35:52 FAQ (legality, MitoQ comparison, oral routes, intranasal)
36:54 Use cases (weight loss, long COVID, athletic performance, TRT, kids)
37:54 Research grade vs pharmaceutical cost difference
38:22 Future outlook (AMD, sarcopenia, SBT-272, oral bioavailability)
40:30 Final thoughts and where SS-31 sits in the broader picture
42:20 Closing
All links here: https://hunterwilliamshealth.com/links
Timestamps:
00:00 Intro
01:00 Why I'm making this video
04:00 The plan: peptides with direct anti-cancer evidence
06:02 AOD-9604 and HGH Frag 176-191
07:42 BPC-157
09:54 DSIP (Delta Sleep Inducing Peptide)
11:08 Epitalon
12:30 Follistatin 344
13:30 GHK-Cu
14:36 Kisspeptin
15:58 KPV
17:18 LL-37
18:46 Melanotan 2
19:58 MOTS-c
21:12 Retatrutide
22:34 Semaglutide
23:40 SS-31
24:38 Thymalin
25:26 Thymosin Alpha-1
27:00 Tirzepatide
27:30 VIP (Vasoactive Intestinal Peptide)
28:06 Bottom line and closing thoughts
Description
If you spend any time in the peptide social media world, you've heard it. "Peptides cause cancer." It's the easiest way to scare someone off something, and a lot of people do it without ever showing you a single study.
So I went and pulled the studies. In this video I walk through every peptide on the popular research peptide list that actually has direct anti-cancer evidence in the published literature. Not theory. Not mechanism guesses. Actual studies in cells, animals, and in some cases, humans.
You'll see what the research says about BPC-157, GHK-Cu, Epitalon, KPV, LL-37, Thymosin Alpha-1, MOTS-c, semaglutide, tirzepatide, retatrutide, and a handful more. Some of this evidence is strong. Some is preliminary. I'm honest about both.
This is not medical advice and I'm not telling you peptides cure cancer. That's not what the data says and that's not what I'm claiming. What I am saying is that the next time someone hits you with a 60 second clip telling you peptides cause cancer, you'll have something more substantial to weigh it against.
All study links below.
📚 Studies Referenced (in order of appearance)
https://pmc.ncbi.nlm.nih.gov/articles/PMC9249349/
BPC-157 https://journals.lww.com/melanomaresearch/citation/2004/08000/bpc_157_inhibits_cell_growth_and_vegf_signalling.50.aspx https://pubmed.ncbi.nlm.nih.gov/29886825/
DSIP
https://pubmed.ncbi.nlm.nih.gov/12782416/
https://pubmed.ncbi.nlm.nih.gov/14501183/ https://pubmed.ncbi.nlm.nih.gov/12209581/ https://pubmed.ncbi.nlm.nih.gov/12049808/
https://pmc.ncbi.nlm.nih.gov/articles/PMC9633376/
https://neoplasiaresearch.com/index.php/jao/article/view/217 https://www.lidsen.com/journals/genetics/genetics-05-02-128
https://pubmed.ncbi.nlm.nih.gov/8944003/ https://pubmed.ncbi.nlm.nih.gov/28944853/
https://pmc.ncbi.nlm.nih.gov/articles/PMC4957955/
https://pmc.ncbi.nlm.nih.gov/articles/PMC3910284/ https://pmc.ncbi.nlm.nih.gov/articles/PMC3659029/
https://pmc.ncbi.nlm.nih.gov/articles/PMC7013727/
https://pmc.ncbi.nlm.nih.gov/articles/PMC11578304/
https://pmc.ncbi.nlm.nih.gov/articles/PMC11908972/
https://pmc.ncbi.nlm.nih.gov/articles/PMC11227080/ https://pubmed.ncbi.nlm.nih.gov/38683947/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12587238/
https://pmc.ncbi.nlm.nih.gov/articles/PMC7923037/
https://pubmed.ncbi.nlm.nih.gov/6752596/ https://pubmed.ncbi.nlm.nih.gov/29797130/
https://pubmed.ncbi.nlm.nih.gov/8652276/ https://pmc.ncbi.nlm.nih.gov/articles/PMC2748379/ https://pubmed.ncbi.nlm.nih.gov/20194853/ https://pubmed.ncbi.nlm.nih.gov/27900029/ https://pubmed.ncbi.nlm.nih.gov/30063847/
https://www.biorxiv.org/content/10.1101/2024.01.20.576484v1 https://aacrjournals.org/cancerres/article/84/6_Supplement/2188/738498/Abstract-2188-Tirzepatide-treatment-restores
VIP
All links here: https://hunterwilliamshealth.com/links
00:00 — Intro and why I'm doing these masterclasses
02:42 — What we're covering and the regulatory timeline
04:04 — The two users: weight loss vs longevity
05:30 — What Retatrutide actually does (the three receptors)
06:50 — Why the glucagon receptor makes Retatrutide different
07:54 — Weight loss trial data (1mg to 12mg)
10:50 — The longevity data: liver fat, ApoB, blood pressure
13:14 — Who the lean biohacker user is
13:50 — The titration playbook
15:32 — Once weekly vs split dosing
19:50 — Morning vs night injections
21:02 — How far to push the dose (why 8mg is the ceiling)
22:50 — How long to stay on and the regain problem
25:44 — Longevity maintenance protocol
26:34 — Lean user protocol
27:24 — Protein and training are non-negotiable
29:06 — Side effects and how to manage them
30:20 — The heart rate question and why I use taurine
32:00 — The weird skin sensitivity issue
33:48 — Pairing Retatrutide with testosterone
35:56 — Drug interactions (blood pressure, thyroid, insulin)
37:02 — Metrics that matter
38:42 — How to cycle off correctly
39:54 — The most common mistakes
40:42 — How to start, what to do if you plateau
43:04 — Should you switch from Tirzepatide?
45:28 — Combining Retatrutide with other peptides
46:50 — The Ten Commandments of Retatrutide use
47:50 — The bottom line
Today's episode is the first in a new format I'm rolling out. I'm working on a book where I cover one peptide at a time, one chapter at a time. Alongside that, I wanted to do a masterclass on each peptide and condense down everything I know into one place. First up is Retatrutide.
I cover what it actually does in your body, the two very different users that should be on it, and the dosing strategies that get debated to death online. We go through the weight loss data, the longevity data, and why I think 8 milligrams is the real ceiling for most people. I also break down once weekly versus split dosing, the heart rate question, the skin sensitivity issue, and why testosterone optimization has to come first.
If you want a definitive guide on Retatrutide, this is it. My goal is that you walk away with a framework you can actually use, whether it's on yourself, your coaching clients, or your patients.
Let me know what you think. I plan on doing many more of these on every peptide that matters.
⚠️ For research and entertainment purposes only. ⚠️
If you do everything right and still feel off, this episode is for you.
I sat down with Peter Cowan, a quantum biology practitioner and environmental health investigator who got chronically sick from EMF exposure, walked away from Silicon Valley, and spent years figuring out why on his own. Peter's Substack series on the San Francisco 49ers, who practice and play right next to a power substation, is some of the most compelling EMF research I've seen anywhere.
We covered the EMF checklist anyone can run at home, the mitochondrial mechanism behind oxidative stress from magnetic fields, how EMF disrupts the cortisol and melatonin cycle that drives your testosterone, why pre-sunrise workouts under fluorescent lights are doing more damage than most people realize, and the three-pronged light protocol that took Peter's testosterone from 437 to over 800.
Follow Peter: https://peteranthonycowan.substack.com/
For research and entertainment purposes only.
👇 ALL MY LINKS IN ONE PLACE
👇 ALL MY LINKS IN ONE PLACE
https://hunterwilliamshealth.com/links
PE-22-28 is one of those peptides almost nobody is talking about, and I think that's a shame. In this episode I walk you through what it is, how it works, and why I'd put it in the antidepressant category before I'd call it a true nootropic.
I get into the background as an optimized analogue of spadin, the TREK-1 channel inhibition that drives the effect, and the downstream impact on BDNF, synaptogenesis, and neuroinflammation. I also cover the part most people care about: the rapid antidepressant onset, usually around four days, versus the three to four weeks you wait on a typical SSRI.
From there I share the dosing protocol I've been using on myself, including a four-on, three-off cycle to keep tolerance low, plus what I've noticed in terms of mood, mental energy, and the lack of any real come-down or withdrawal.
I'm not saying this is a cure for depression. Depression is multifaceted and deserves a multifaceted approach. But if you need something to help get you out of the hole and back into the habits that actually move the needle, PE-22-28 is worth knowing about.
Hunter and Taylor are back for another deep dive Reader Mailbag. Real questions, real answers, no shortcuts.
This week: traveling with peptides and TRT through customs, fixing glutathione injection pain, melanatan 1 vs 2 and skin cancer risk, severe female insomnia and perimenopause sleep protocols, retatrutide plateaus and GLP-1 desensitization, and how to actually build a peptide stack using the bleeding neck framework.
Whether you're new to peptides or deep in your optimization journey this one has something for everyone.
Submit your questions for the next episode at the link below.
For research and entertainment purposes only.
👇 EVERYTHING IN ONE PLACEhttps://hunterwilliamshealth.com/links
👇 ALL MY LINKS IN ONE PLACE
https://hunterwilliamshealth.com/links
GLP-1s like retatrutide are the kings of fat loss. No argument there. But what do you actually do when you're cycling off, when GLP-1s aren't on the table, or when you want to stack something alongside your GLP-1 so you don't have to escalate the dose?
In this video I rank 20 non-GLP-1 fat loss compounds from F-tier to S-tier. Most are peptides. A few are small molecules. Some I use all the time. Some I would never touch.
I cover the mechanisms, the dosing protocols I actually run, the side effects I've personally experienced, and where each one fits in a real fat loss program. You'll get my honest take on adipotide, AOD-9604, sermorelin, setmelanotide, tesofensine, SS-31, cagrilintide, IGF-1 LR3, cardarine, CJC/ipamorelin, MOTS-c, 5-amino-1MQ, BAM15, SLU-PP-332, ATX-304, mirabegron, albuterol, HGH, and tesamorelin.
Hormones and lifestyle come first. Always. But once those are dialed in, these are the tools worth knowing about.
If you want my peptide cheat sheet and links to everything I use, check the description
below. And if you want to ask me questions directly, come hang out in the Axion Collective.
👇 ALL MY LINKS IN ONE PLACE
https://hunterwilliamshealth.com/links
Low-dose naltrexone is one of my favorite compounds out there, and in this updated 2026 episode I'm breaking down why it deserves a spot in your protocol. I cover the four mechanisms that make LDN work: the endorphin rebound, the OGF/OGFR axis, TLR4 antagonism, and broad anti-inflammatory signaling. Then I get into where LDN actually shines clinically. Autoimmune conditions like Hashimoto's and Crohn's. Chronic pain and fibromyalgia. Depression. PCOS and fertility. Even skin issues like acne, which I've personally dealt with for years.
But the part I'm most excited about is how LDN stacks with hormones and peptides. I walk through why it pairs so well with TRT, estrogen, and thyroid optimization, and then I get into specific peptide combos including BPC-157, TB-500, thymosin alpha-1, KPV, SS-31, and GLP-1 agonists. I also share why LDN might let you stay at lower GLP-1 doses for longer.
I cover dosing, titration, side effects, and my own experience cycling versus staying on continuously. If you're already optimizing with peptides and hormones, LDN might be that last five to ten percent that makes everything else work better.
00:00 – Intro and why LDN deserves an updated episode
02:22 – Why LDN belongs in your protocol (40-year safety record, broad benefits)
03:44 – The history of LDN and Dr. Bernard Bihari's HIV discovery
05:42 – The four mechanisms of action explained
06:30 – The OGF/OGFR axis and cancer applications
07:30 – TLR4 antagonism and the immune benefits
09:24 – Where LDN shines: autoimmune, pain, gut, depression, PCOS, skin
13:14 – Dosing, titration, and timing (night vs morning)
15:06 – Side effects, contraindications, and safety
16:14 – LDN and hormone replacement therapy synergy
18:34 – LDN for men on TRT, sexual function, and cortisol
20:48 – LDN stacked with peptides (BPC-157, TB-500, KPV, SS-31, GLP-1s, TA-1)
28:38 – My personal take on cycling vs daily use
30:16 – Closing thoughts
Timestamps