Conan and special guest Taylor Tomlinson speak to flavor scientist Jeremy in San Francisco about how to properly cleanse a palate, performing over 100 sensory tastings in six months, and the one flavor that is universally despised.

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Actor Kyle MacLachlan feels fortunate about being Conan O’Brien’s friend.

Kyle sits down with Conan to discuss his new memoir Fictional Selves, how being plucked from the stage to star in the 1984 adaptation of Dune led to a lifelong collaboration with director David Lynch, and bringing a unique eccentricity to his iconic role as Agent Cooper in Twin Peaks. Plus, Conan responds to a listener voicemail about where this world is going.

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Conan returns with producers Mike Sweeney, Jessie Gaskell, and Jose Arroyo for a deep dive into his travels through Morocco and the Philippines on the newest season of Conan O’Brien Must Go.

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Actor Owen Wilson feels good about being Conan O’Brien’s friend.

Owen sits down with Conan to discuss how military school led him to a creative partnership with Wes Anderson, learning how to wear a cowboy hat, bringing Timothy Olyphant on for season two of Stick, his new film Rolling Loud: The Movie, and more.

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Conan sits down with the creative team behind Conan O’Brien Must Go (Mike Sweeney, Jessie Gaskell, Jose Arroyo) for a behind-the-scenes look at season three, discussing everything from setting up sting operations for phone-thieving monkeys in India to learning how to model in the Netherlands and much, much more.

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Actors Matthew McConaughey and Woody Harrelson feel very Irish and like a True American, respectively, about being Conan O’Brien’s Friend. Matthew and Woody sit down with Conan to discuss how they first met, their very different approaches to acting, how much of their new show Brothers is based on their real-life personas, and whether they might actually be brothers. Plus, Conan responds to an article about a missing Conan O’Brien commemorative plaque. 

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Conan continues chatting with body mod expert Grace from Bristol to learn about extreme genital modification, body suspension, and more.

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Actor, comedian, and television host Joel McHale feels blank about being Conan O’Brien’s friend.

Joel sits down with Conan once more to discuss solo spousal vacations, adventurous palates, his early days performing theater sports at Pike Place, and absurd internet impulse buys. Later, Conan ponders which president he could portray while he and the team Review the Reviewers.

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Conan talks to tattoo artist Grace from Bristol about the wide world of body modification from tongue-splitting to belly button removal and beyond.

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Comedian Taylor Tomlinson feels gobsmacked about being Conan O’Brien’s friend.

Taylor sits down with Conan once again to discuss her new book Actually, Nevermind, high school marching band, bipolar II disorder, losing a parent at a young age, and oddities of American Girl dolls.

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Conan and special guest Andy Daly chat with Peter in Framingham, MA about working for the CPCS Innocence Program, the best sources of DNA, and how to bring comedy into difficult conversations.

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Writer and animator Matt Groening feels honored about being Conan O’Brien’s friend.

Matt sits down with Conan to discuss fond memories of The Simpsons writers' rooms of yesteryear, keeping track of jokes over 800+ episodes, and mining the future for endless comedy with Futurama. Later, Sona reports on a mishandled attempt to have Conan’s food delivered.

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On the sixth and final Summer S’pouses, Conan, Sona, and Matt reunite with Liza, Tak, and Amanda for one final multi-matrimonial dialogue.

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Comedian and actor Andy Daly feels at peace about being Conan O’Brien’s friend.

Andy sits down with Conan to discuss wrestling his pets, his controversial persona in high school, and the first big laughs that set him on a lifelong comedic track. Plus, Conan’s team discusses lending their voices to the animated Disney series Big City Greens.

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The Spouses (Liza, Tak, and Amanda) sit down by themselves to discuss the unexpected ways in which the podcast has altered their lives.

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Actor and wrestler John Cena feels curiously enthusiastic about being Conan O’Brien’s friend.

John sits down with Conan to discuss wrestling as a training ground for comedy, minimizing self-sabotage, the importance of a long-term mindset, and his latest role in the new live-action animated comedy Coyote vs. Acme.

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Liza Powel O’Brien feels so many things about being Conan O’Brien’s spouse.

Liza sits down with Conan, Sona, and Matt to discuss being married to a man with absurd eating habits.

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Actress Gillian Anderson feels nonplussed about being Conan O’Brien’s friend.

Gillian sits down with Conan to discuss her iconic role as Agent Scully on The X Files, exploring complexities of character as Margaret Thatcher on The Crown, and putting out the call for authentic desires for her latest book More: Sexual Fantasies by Anonymous. Plus, Conan and Sona take a platonic friendship quiz.

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Tak Boroyan is still adjusting to being Sona Movsesian’s spouse.

Tak sits down with Conan, Matt, and Sona to discuss emigrating from Soviet Armenia at a young age, his first date with Sona, and his favorite music to play (that she can’t stand).

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Actress and writer Greta Lee feels excited about being Conan O’Brien’s friend.

Greta sits down with Conan to discuss her childhood deeply rooted in Korean identity, experiencing a massive cultural shift moving to the Midwest, experiencing the impact of her role in the 2023 romantic drama Past Lives on audiences, and her upcoming Netflix film The Last House. Later, Sona celebrates husband Tak’s recent promotion to black belt in karate.

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Amanda Lund feels ‘you go girl’ about being Matt Gourley’s spouse.

Amanda talks to Conan and the crew about performing as a Disney princess at Tokyo Disney, satirizing The Total Woman, and Matt’s shocking secret side hustle.

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Rapper, actor, and producer Ice Cube feels like he’s about to throw up in his mouth about being Conan O’Brien’s friend.

Ice Cube sits down with Conan to discuss how a typewriting class inspired him to write rap, following the vision of Eazy-E as N.W.A. skyrocketed to worldwide success, founding the pro 3-on-3 basketball league BIG3, and much more.

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The Chums make preparations for the arrival of their spouses to the podcast on a special new summer series.

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Comedian Leslie Jones feels so conflicted about being Conan O’Brien’s friend.

Leslie sits down with Conan once more to discuss the qualities of her ideal man, aspiring to catch a serial killer, her friendship with Kenan Thompson, her new HGTV show Roast My Rental, and more.

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Conan talks to blade smith Josh from Liverpool, NY about how to craft the perfect knife.

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Actress Molly Shannon feels proud and cool to be Conan O’Brien’s friend.

Molly sits down with Conan once more to discuss her rule-breaking youth, creative ways to calm the brain, and her longtime friendship with Will Ferrell leading all the way up to their new Netflix series The Hawk. Plus, David Hopping reveals a disturbing corner of TikTok focusing on Conan’s Toy Story 5 character Smarty Pants.

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Conan contemplates reaching a whole new audience while unboxing more Toy Story 5 merch of his character Smarty Pants.

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Rolling Stones lead singer Mick Jagger feels rather anxious about being Conan O’Brien’s friend.

Mick sits down with Conan to discuss the Stones’ 25th studio album Foreign Tongues, his six-decade (and counting) career at the forefront of rock music history, friendly competition with the likes of David Bowie and John Lennon, and finding ways to live in the moment while continuing to draw from the past.

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Conan chats with wedding vow writer Brian about the value of sincerity, the worst revelations he’s witnessed during a speech, and more.

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Actor, writer, and producer Danny McBride feels thrilling about being Conan O’Brien’s friend.

Danny sits down with Conan once more to discuss his favorite childhood cartoons, pitching his Halloween sequel directly to John Carpenter, how writing for television prepared him to craft his book of short stories Thrilling Tales of Modern Men: Stories, and more.

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Conan faces the difficult task of selecting an experience from Sona’s massive gift box of edible treats.

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Comedian, writer, and actor Eric Andre feels like sandpaper about being Conan O’Brien’s friend.

Eric sits down with Conan to discuss and his mental health, his Uber conversation preferences, and his new film with John Cena, Little Brother. Plus, the gang consider Conan as a terminator in a new installment of Review The Reviewer.

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Conan and Sona report on their recent travel adventures from the backseat of a car in Morocco while en route to Marrakesh.

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Singer-songwriter Josh Groban feels downright giddy about being Conan O’Brien’s friend.

Josh sits down with Conan to discuss his breakout moment at 16 singing with Céline Dion at the Grammys, finding ways to exercise his comedic inclinations, and asking his dad to play trumpet on his latest album Cinematic. Plus, Conan comes face to face with his character’s real-life toy from the upcoming Toy Story 5.

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Conan talks to kinetic sculptor Breakfast about how to create moving pieces of art and designing a 50-foot sphere for cruise ships.

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Comedian Atsuko Okatsuka feels honored and a little suspicious about being Conan O’Brien’s friend.
 

Atsuko sits down with Conan to discuss her latest stand-up special Father, being kidnapped by her grandmother to the United States, learning how to make her family laugh, lifelong friends made in cheerleading, and more. Later, Conan reviews his own collection of very authentic reviews.

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Conan chats with Zach, an animator from Ohio, about proposing underneath a cosmic event and designing his own trading card game.

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Comedian and actor Patton Oswalt feels relieved about being Conan O’Brien’s friend.

Patton sits down with Conan once again to discuss the ridiculousness of the modern day press tour, obsessing over Martin and Lewis knock-offs, and exploring the idea of finding comfort in being overwhelmed in his newest special Tea & Scotch.

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Conan talks to Brooke in New York City about working as an intimacy coordinator, closure practices, and the most common inaccuracies while filming a sex scene.

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Conan delivers the 2026 Harvard commencement address.

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Tá áthas ar Andrew Scott about being Conan O’Brien’s friend.

Andrew sits down with Conan to discuss his latest film Pressure, the over-academization of Shakespeare, playing every part in the one-man adaptation Vanya, and honing the craft of portraying characters who are good without being nice. Later, Conan reveals a wholesomely surefire way to put himself into an unbreakable trance.

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Conan talks to Micah in Atlanta about working as the collections manager at the Center For Puppetry Arts and her love of niche fan fiction.

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Actress Olivia Munn feels so excited and amazed about being Conan O’Brien’s friend.

Olivia sits down with Conan to discuss accidentally creating core memories for her kids, breaking the family mold by pursuing acting, and advocating for breast cancer awareness and early detection after her own diagnosis. Later, Conan tests his modern slang while he and his team Review the Reviewers.

Breast Cancer Lifetime Risk Assessment: https://magview.com/ibis-risk-calculator/

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Conan explores how his reluctance to follow Sona down the path of hedonism is the result of a complex family history.

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Musician Charlie Puth feels blank about being Conan O’Brien’s friend.

Charlie sits down with Conan to discuss his worldwide tour for his latest album Whatever’s Clever!, how to change the energy of a room with a single sound, why musicians who make it all about themselves are the first to fall, and more.

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Conan talks to OBGYN Jessica in New Jersey to receive a long overdue lesson on human anatomy.

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Singer Billie Eilish feels really good about being Conan O’Brien’s friend.

Billie sits down with Conan once more to discuss the name her parents almost gave her, co-directing her new concert film Billie Eilish - Hit Me Hard and Soft: The Tour (Live in 3D) with James Cameron, striving for reachability with her audience, and more.

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Get access to all the podcasts you love, music channels and radio shows with the SiriusXM App! Get 3 months free using this show link: https://siriusxm.com/conan.

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Conan talks to Cooper, an architectural historian from Ohio, about submitting nominations to the historic registry and to find out what kind of building Conan would be.

Wanna get a chance to talk to Conan? Submit here: teamcoco.com/apply

Get access to all the podcasts you love, music channels and radio shows with the SiriusXM App! Get 3 months free using this show link: https://siriusxm.com/conan.

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Actor and comedian Zach Galifianakis feels Zach Galifianakis about being Conan O’Brien’s friend.

Zach sits down with Conan once more to discuss his early days as a busboy at a strip joint, why it’s so important for comics to take on the powerful, and pouring his passion for gardening into his new show This Is a Gardening Show.

For Conan videos, tour dates and more visit TeamCoco.com.

Got a question for Conan? Call our voicemail: (669) 587-2847.

Get access to all the podcasts you love, music channels and radio shows with the SiriusXM App! Get 3 months free using this show link: https://siriusxm.com/conan.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Conan talks to Phillip from Colonial Williamsburg about relic hunting for lost treasures (and sometimes live hand grenades) and why you should always fill in your holes after a search.

Wanna get a chance to talk to Conan? Submit here: teamcoco.com/apply

Get access to all the podcasts you love, music channels and radio shows with the SiriusXM App! Get 3 months free using this show link: https://siriusxm.com/conan.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.