Welcome to the April 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with questions and transcript: https://www.preposterousuniverse.com/podcast/2025/04/07/ama-april-2025/

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A couple of links relevant to the intro:

Tariff formula (Snopes)Tufts student nabbed by ICE (plus video)

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Cosmologists were, let us be honest, pretty stunned in 1998 when observations revealed that the universe is accelerating. There was an obvious plausible explanation, the cosmological constant proposed by Einstein, which is equivalent to a constant vacuum energy pervading space. But the cosmological constant was known to be enormously smaller than its "natural" value, and it seems fine-tuned for it to be so small but not yet zero. Once burned, twice shy, and since then we have been looking for evidence that the dark energy might not be strictly constant, even though that's even more fine-tuned. We talk to cosmologist Marc Kamionkowski about recent evidence that dark energy might be changing with time, and what this might have to do with the Hubble tension and other cosmic anomalies.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/03/31/310-marc-kamionkowski-on-dark-energy-and-cosmic-anomalies/

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Marc Kamionkowski received his Ph.D. in physics from the University of Chicago. He is currently the William R. Kenan Jr. Professor in the Department of Physics and Astronomy at Johns Hopkins University. Among his prizes are the Gruber Cosmology Prize, the Dannie Heineman Prize for Astrophysics, membership in the National Academy of Science, and a Guggenheim Fellowship.

Johns Hopkins web pageGoogle Scholar publicationsWikipediaKamionkowski and Riess, "The Hubble Tension and Early Dark Energy"Dark Energy Spectroscopic Instrument paper and followupDark Energy Survey paper

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Consciousness is easier to possess than to define. One thing we can do is to look into the brain and see what lights up when conscious awareness is taking place. A complete understanding of this would be known as the "neural correlates of consciousness." Once we have that, we could hopefully make progress on developing a theoretical picture of what consciousness is and why it happens. Today's guest, Christof Koch, is a leader in the search for neural correlates and an advocate of a particular approach to consciousness, Integrated Information Theory.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/03/24/309-christof-koch-on-consciousness-and-integrated-information/

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Christof Koch was awarded a Ph.D. from the Max Planck Institute for Biological Cybernetics. He is currently a Meritorious Investigator at the Allen Institute for Brain Science, where he was formerly president and chief scientist, and Chief Scientist at the Tiny Blue Dot Foundation. He is the author of several books, most recently Then I Am Myself the World - What Consciousness Is and How to Expand It.

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We often study cognition in other species, in part to learn about modes of thinking that are different from our own. Today's guest, psychologist/philosopher Alison Gopnik, argues that we needn't look that far: human children aren't simply undeveloped adults, they have a way of thinking that is importantly distinct from that of grownups. Children are explorers with ever-expanding neural connections; adults are exploiters who (they think) know how the world works. These studies have important implications for the training and use of artificial intelligence.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/03/17/308-alison-gopnik-on-children-ai-and-modes-of-thinking/

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Alison Gopnik received her D.Phil in experimental psychology from Oxford University. She is currently a professor of psychology and affiliate professor of philosophy at the University of California, Berkeley. Among her awards are the Association for Psychological Science Lifetime Achievement Award, the Rumelhart Prize for Theoretical Foundations of Cognitive Science, and a Guggenheim Fellowship. She is a past President of the Association for Psychological Science. She is the author of The Scientist in the Crib, The Philosophical Baby, and The Gardener and the Carpenter, among other works.

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Welcome to the March 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Link to the 2012 Moving Naturalism Forward workshop, mentioned in the episode.

Blog post with questions and full transcript: https://www.preposterousuniverse.com/podcast/2025/03/10/ama-march-2025/

Support Mindscape on Patreon.

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A lot of science goes into crafting the perfect cocktail. Balancing sweet and bitter notes, providing the right amount of aeration and dilution, getting it to just the right temperature and keeping it that way. And even if you have no interest in cocktails as such, the general principles extend to other activities in art and in life. I talk to scientist-turned-mixologist Kevin Peterson about how to think about the simple magic of a perfect drink.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/03/03/307-kevin-peterson-on-the-theory-of-cocktails/

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Kevin Peterson received a Ph.D. in Mechanical Engineering from the University of Michigan. He is currently co-owner of both Castalia (an experimental craft cocktail bar) and Sfumato Fragrances in Detroit, Michigan. He is the author of Cocktail Theory: A Sensory Approach to Transcendent Cocktails.

Mindscape Petrichor Negroni (from the episode)

1 part gin distilled from vetiver(alternative: herbaceous gin such as Moletto)1 part St. George Bruto Americano1 part Antica Formula vermouth

Stir over an ice cube, express with orange peel (not shown).

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It is commonplace to refer to the Earth's oceans as vast and largely unexplored. But we do understand some aspects, and improving that understanding is crucial to ensuring the continued viability and success of life on this planet. The oceans are a paradigmatic complex system: there are many components, distinct but mutually interacting, that add up to a nuanced whole. We talk with ocean physicist Helen Czerski about what the ocean is and how it's changing.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/02/24/306-helen-czerski-on-our-energetic-oceans/

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Helen Czerski received her Ph.D. in physics from the University of Cambridge. She is currently an Associate Professor at the Department of Mechanical Engineering at University College London. She is the author of several books, most recently The Blue Machine: How the Ocean Works. She is a frequent television presenter for the BBC and elsewhere.

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Political outcomes would be relatively simple to predict and understand if only people were well-informed, entirely rational, and perfectly self-interested. Alas, real human beings are messy, emotional, imperfect creatures, so a successful theory of politics has to account for these features. One phenomenon that has grown in recent years is an alignment of cultural differences with political ones, so that polarization becomes more entrenched and even violent. I talk with political scientist Lilliana Mason about how this has come to pass, and how democracy can deal with it.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/02/17/305-lilliana-mason-on-polarization-and-political-psychology/

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Lilliana Hall Mason received her Ph.D. in political psychology from Stony Brook University. She is currently an SNF Agora Institute Associate Professor of Political Science at Johns Hopkins University. She is the author of Uncivil Agreement: How Politics Became Our Identity and co-author (with Nathan Kalmoe) of Radical American Partisanship: Mapping Violent Hostility, Its Causes, and the Consequences for Democracy.

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The Trump administration, led by Elon Musk and his Department of Government Efficiency, has proposed sweeping cuts to spending on science research here in the US, in particular at the National Institutes of Health and the National Science Foundation. I explain a little about what is being cut and why these funds are important to scientific progress. I try, for what it's worth, to provide these explanations in a way that would be informative to those who generally favor cutting government waste in dramatic fashion.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/02/12/bonus-cuts-to-science-funding-and-why-they-matter/

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Indirect costs primerCuts to NIH indirect costsAppropriated funds are mandated by statuteProposed NSF cutsElon Musk doesn't understand indirect costsShrimp treadmill storyBribing foreign officialsDeleting NSA web pagesExecutive Orders are not lawsHistory of impoundments

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It is a feature of many human activities - sports, cooking, music, interpersonal relations - that being able to do them well doesn't necessarily mean you can accurately describe how to do them well. Science is no different. Many successful scientists are not very good at explaining what goes into successful scientific practice. To understand that, it's necessary to study science in a scientific fashion. What kinds of scientists, in what kinds of collaborations, using what kinds of techniques, do well? I talk with James Evans, an expert on collective intelligence and the construction of knowledge, about how science really works.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/02/10/304-james-evans-on-innovation-consolidation-and-the-science-of-science/

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James Evans received his Ph.D. in Sociology from Stanford University. He is currently the Max Palevsky Professor of History and Civilizations, Director of Knowledge Lab, and Faculty Director of Computational Social Science at the University of Chicago; External Professor at the Santa Fe Institute; External Faculty at the Complexity Science Hub, Vienna; and Visiting Faculty Researcher at Google.

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Welcome to the February 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with questions and transcript: https://www.preposterousuniverse.com/podcast/2025/02/03/ama-february-2025/

Support Mindscape on Patreon.

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A typical human lifespan is approximately three billion heartbeats in duration. Lasting that long requires not only intrinsic stability, but an impressive capacity for self-repair. Nevertheless, things do occasionally break down, and cancer is one of the most dramatic examples of such breakdown. Given that the body is generally so good at protecting itself, can we harness our internal security patrol - the immune system - to fight cancer? This is the hope of Nobel Laureate James Allison, who works on studying the structure and behavior of immune cells, and ways to coax them into fighting cancer. This approach offers hope of a way to combat cancer effectively, lastingly, and in a relatively gentle way.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/27/303-james-p-allison-on-fighting-cancer-with-the-immune-system/

James P. Allison received his Ph.D. in biology from the University of Texas at Austin. He is currently Regental Professor and Chair of the Department of Immunology, the Olga Keith Wiess Distinguished University Chair for Cancer Research, Director of the Parker Institute for Cancer Research, and Director of the James P. Allison Institute at MD Anderson Cancer Center. He is the subject of the documentary film Jim Allison: Breakthrough. Among his numerous awards are the Breakthrough Prize in Life Sciences and the Nobel Prize in Physiology or Medicine.

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Randomness plays an important role in the evolution of life (as my evil twin will tell you). But random doesn't mean arbitrary. Biological organisms are physical objects, after all, and subject to the same laws of physics as non-biological matter is. Those laws place constraints on how organisms can fulfill their basic functions of metabolism, reproduction, motility, and so on. Easy to say, but how can we turn this into quantitative understanding of actual organisms? Today I talk with physical biologist Chris Kempes about how physics can help us understand the size of organisms, their metabolisms, and features of major transitions in evolution.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/20/302-chris-kempes-on-the-biophysics-of-evolution/

Chris Kempes received his Ph.D. in physical biology from the Massachusetts Institute of Technology. He is currently Professor and a member of the Science Steering Committee at the Santa Fe Institute. His research involves the origin of life and the constraints placed by physics on biological function and evolution.

Web siteSanta Fe Institute web pageGoogle Scholar publicationsOrigins of Life online course

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Big data is ruling, or at least deeply infiltrating, all of modern existence. Unprecedented capacity for collecting and analyzing large amounts of data have given us a new generation of artificial intelligence models, but also everything from medical procedures to recommendation systems that guide our purchases and romantic lives. I talk with computer scientist Tina Elassi-Rad about how we can sift through all this data, make sure it is deployed in ways that align with our values, and how to deal with the political and social dangers associated with systems that are not always guided by the truth.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/13/301-tina-eliassi-rad-on-al-networks-and-epistemic-instability/

Tina Eliassi-Rad received her Ph.D. in computer science from the University of Wisconsin-Madison. She is currently Joseph E. Aoun Chair of Computer Sciences and Core Faculty of the Network Science Institute at Northeastern University, External Faculty at the Santa Fe Institute, and External Faculty at the Vermont Complex Systems Center. She is a fellow of the Network Science Society, recipient of the Lagrange Prize, and was named one of the 100 Brilliant Women in AI Ethics.

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A new year, and a new centennial -- 300 (regularly-numbered) episodes of Mindscape! Our tradition is to have a solo episode, and what better topic than the nature of time? Physicists and philosophers have so frequently suggested that time is some kind of illusion that it's become almost passé to believe that it might be fundamental. This is an issue where, despite the form of the question, physics has important things to say that most philosophers haven't yet caught up to. I will talk about ideas from quantum mechanics and quantum gravity that bear on the question of whether time is emergent or fundamental, and the implications of each possibility.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/06/300-solo-does-time-exist/

Some of the papers discussed herein:

Carroll (2008), "What If Time Really Exists?"Dyson, Kleban, and Susskind (2002), "Disturbing Implications of a Cosmological Constant."Albrecht and Sorbo (2004), "Can the Universe Afford Inflation?"Boddy, Carroll, and Pollack (2014), "De Sitter Space Without Dynamical Quantum Fluctuations."Lloyd (2016), "Decoherent Histories Approach to the Cosmological Measure Problem."Page and Wootters (1983), "Evolution Without Evolution: Dynamics Described by Stationary Observables."Albrecht (1994), "The Theory of Everything vs the Theory of Anything."Albrecht and Iglesias (2007), "The Clock Ambiguity and the Emergence of Physical Laws."

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It's the end of the year, and time for our annual holiday break here at Mindscape. But as usual, we wrap up with a Holiday Message. This year, inspired by Joni Mitchell's "Hits" and "Misses" albums, I go through my scientific papers and talk about some of my favorites -- some of which were hits, in terms of making an impact on subsequent research, and some of which were misses by that standard. But I love them all! It's an excuse to talk about process -- how papers come to be, from the initial informal idea to sitting down and doing the work.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/23/holiday-message-hits-and-misses/

Here are links to the papers I discuss in the episode.

S.M. Carroll, G.B. Field and R. Jackiw, 1990, "Limits on A Lorentz and Parity-Violating Modification of Electrodynamics,'' Phys. Rev. D 41, 1231. [pdf file; inSPIRE]S.M. Carroll, E. Farhi and A.H. Guth, 1992, "An Obstacle to Building a Time Machine,'' Phys. Rev. Lett. 68, 263; Erratum: 68, 3368. [pdf file; inSPIRE]S.M. Carroll, E. Farhi, A.H. Guth and K.D. Olum, 1994, "Energy-Momentum Restrictions on the Creation of Gott Time Machines,'' Phys. Rev. D 50, 6190; gr-qc/9404065. [arXiv; pdf; inSPIRE]S.M. Carroll, 1998, "Quintessence and the Rest of the World,'' Phys. Rev. Lett. 81, 3067; astro-ph/9806099. [arXiv; pdf; inSPIRE]S.M. Carroll, V. Duvvuri, M. Trodden, and M.S. Turner, 2003, "Is Cosmic Speed-Up Due to New Gravitational Physics?'' astro-ph/0306438. [arXiv; pdf; inSPIRE]S.M. Carroll and J. Chen, 2004, "Spontaneous Inflation and the Origin of the Arrow of Time'', hep-th/0410270. [arXiv, inSPIRE]L. Ackerman, M.R. Buckley, S.M. Carroll, and M. Kamionkowski, 2008, "Dark Matter and Dark Radiation," arxiv:0807.5126. [arXiv; pdf; inSPIRE]S.M. Carroll, M.C. Johnson, and L. Randall, 2009, "Dynamical Compactification," arxiv:0904.3115. [arXiv; pdf; inSPIRE]C. Cao, S.M. Carroll, and S. Michalakis, 2016, "Space from Hilbert Space: Recovering Geometry from Bulk Entanglement," arxiv:1606.08444. [arXiv, inSPIRE]C. Cao and S.M. Carroll, 2018, "Bulk Entanglement Gravity without a Boundary: Towards Finding Einstein's Equation in Hilbert Space," arxiv:1712.02803. [arXiv, inSPIRE]N. Bao, S.M. Carroll, A. Chatwin-Davies, J. Pollack, and G. Remmen, 2017, ?Branches of the Black Hole Wave Function Need Not Contain Firewalls," arxiv:1712.04955. [arXiv, inSPIRE]

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Living organisms seem exquisitely organized and complex, with features clearly adapted to serving certain functions needed to survive and procreate. Natural selection provides a compelling explanation for why that is so. But is there a bigger picture, a more general framework that explains the origin and evolution of functions and complexity in a world governed by uncaring laws of physics? I talk with planetary scientist and astrobiologist Michael Wong about how we can define what "functions" are and the role they play in the evolution of the universe.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/16/299-michael-wong-on-information-function-and-the-origin-of-life/

Michael Wong received his Ph.D. in planetary science from Caltech. He is currently a Sagan Postdoctoral Fellow at the Carnegie Institution for Science?s Earth & Planets Laboratory. He is in the process of co-authoring two books: A Missing Law: Evolution, Information, and the Inevitability of Cosmic Complexity with Robert M. Hazen, and a revised edition of Astrobiology: A Multidisciplinary Approach with Jonathan Lunine.

Web siteCarnegie web pageStrange New Worlds podcastWong et al. (2023), "On the Roles of Function and Selection in Evolving Systems."Wong and Prabhu (2023), "Cells as the First Data Scientists."

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The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome: the complete map of those connections. For a human brain that's an intimidatingly complex challenge, but important advances have been made on tinier brains. We talk with Jeff Lichtman, a leader in brain mapping, to gauge the current state of progress and what it implies.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/

Jeff Lichtman received an MD/PhD from Washington University in St. Louis. He is currently the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is co-inventor of the Brainbow system for imaging neurons. He is a member of the National Academy of Sciences.

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Welcome to the December 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2024/12/02/ama-december-2024/

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Not too long ago, Brad Pitt and Eric Bana starred in a (loose) adaptation of Homer's epic poem The Iliad; next month, Ralph Fiennes and Juliette Binoche will headline a film based on The Odyssey. Given that the originals were written (or at least written down) in the 8th century BCE, that is some impressive staying power. But they were also written in a very different time than ours, with different cultural context and narrative expectations. We talk about the issues of translation in general, and these Greek classics in particular, with Emily Wilson, whose recent translations of The Iliad and The Odyssey have garnered worldwide acclaim.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/11/25/297-emily-wilson-on-homer-poetry-and-translation/

Emily Wilson received her Ph.D. in classical and comparative literature from Yale. She is currently Professor of Classical Studies at the University of Pennsylvania. Among her awards are the Charles Berheimer Prize from the American Comparative Literature Association, a Rome Prize fellowship from the American Academy in Rome, and Guggenheim and MacArthur fellowships.

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Biological evolution via natural selection is a simple idea that becomes enormously complicated in its realization. Populations of organisms are driven toward increased "fitness," a measure of how successfully we reproduce our genetic information. But fitness is a subtle concept, changing with time and environment and interactions with other organisms around us. We talk with biologist Brandon Ogbunu about the best mathematical and conceptual tools for thinking about the messy complexities of evolution, and how modern technology is changing our way of thinking about it.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/11/18/296-brandon-ogbunu-on-fitness-seascapes-and-the-course-of-evolution/

Brandon Ogbunu received his Ph.D. in Genetics and Microbiology from Yale University. He is currently Assistant Professor of Ecology and Evolutionary Biology at Yale, and External Faculty at the Santa Fe Institute. He has been awarded a Fullbright Fellowship and was the Martin Luther King Jr. Visiting Professor at MIT. He has contributed to a number of publications, including Wired, Undark, and Quanta.

Lab web siteYale web pageGoogle Scholar publicationsWikipediaPublic talk: What is Lyfe? Towards a Biology of Context & Complexity

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Emergence is a centrally important concept in science and philosophy. Indeed, the existence of higher-level emergent properties helps render the world intelligible to us -- we can sensibly understand the macroscopic world around us without a complete microscopic picture. But there are various different ways in which emergence might happen, and a tendency for definitions of emergence to rely on vague or subjective criteria. Recently Achyuth Parola and I wrote a paper trying to clear up some of these issues: What Emergence Can Possibly Mean. In this solo podcast I discuss the way we suggest to think about emergence, with examples from physics and elsewhere.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/11/11/295-solo-emergence-and-layers-of-reality/

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Welcome to the November 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

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Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2024/11/04/ama-november-2024/

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Erwin Schrödinger said that the important characteristic of life is that it "goes on doing something... for a much longer period than we would expect an inanimate piece of matter to keep going under similar circumstances." Living organisms are in constant motion inside; so where does this stability and persistence come from? Addy Pross points to a novel kind of chemical phenomenon -- "dynamic kinetic stability" (DKS), a feature that enables a chemical "fountain" to persist in the presence of an energy source. This suggests an interesting perspective on the question of life's origin, and perhaps on the origin of consciousness.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/10/28/294-addy-pross-on-dynamics-stability-and-life/

Addy Pross received his Ph.D. in chemistry from the University of Sydney. He is currently Professor Emeritus of Chemistry at Ben-Gurion University. He has held visiting positions in the University of Lund, Stanford University, Rutgers University, University of California at Irvine, University of Padova, the Australian National University Canberra, and the University of Sydney. He is the author of What Is Life? How Chemistry Becomes Biology.

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A large economy is one of the best examples we have of complex dynamics. There are multiple components arranged in complicated overlapping hierarchies, out-of-equilibrium dynamics, nonlinear coupling and feedback between different levels, and ubiquitous unpredictable and chaotic behavior. Nevertheless, many economic models are based on relatively simple equilibrium principles. Doyne Farmer is among a group who think that economists need to start taking the tools of complexity theory seriously, as he argues in his recent book Making Sense of Chaos: A Better Economics for a Better World.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/10/21/293-doyne-farmer-on-chaos-crashes-and-economic-complexity/

J. Doyne Farmer received his Ph.D. in physics from the University of California, Santa Cruz. He is currently Director of the Complexity Economics program and Baillie Gifford Professor of Complex Systems Science at the University of Oxford, External Professor at the Santa Fe Institute, and Chief Scientist at Macrocosm. He was the founder of the Complex Systems Group in the Theoretical Division at Los Alamos National Laboratory, and co-founder of The Prediction Company.

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It's not immoral to kick a rock; it is immoral to kick a baby. At what point do we start saying that it is wrong to cause pain to something? This question has less to do with "consciousness" and more to do with "sentience" -- the ability to perceive feelings and sensations. Philosopher Jonathan Birch has embarked on a careful study of the meaning of sentience and how it can be identified in different kinds of organisms, as he discusses in his new open-access book The Edge of Sentience. This is an example of a question at the boundary of philosophy and biology with potentially important implications for real-world policies.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/10/14/292-jonathan-birch-on-animal-sentience/

Jonathan Birch received his Ph.D. in the philosophy of science from the University of Cambridge. He is currently a Professor in the Department of Philosophy Logic and Scientific Method at the London School of Economics and Political Science (LSE). He is one of the authors of the New York Declaration on Animal Consciousness, and has advised the British government on matters of animal cruelty and sentience.

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Welcome to the October 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

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Blog post with questions and transcript: https://www.preposterousuniverse.com/podcast/2024/10/07/ama-october-2024/

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Aging and death happen to the best of us, but there are increasing efforts to do something about it. That effort requires that we have some reasonable understanding of why aging happens, and what processes are involved. You will be unsurprised to learn that it's complicated. Venki Ramakrishnan, who won the Nobel Prize for his work on the ribosome, investigates what we know about aging in his book Why We Die: The New Science of Aging and the Quest for Immortality. We talk about aging and death, and manage to get some thoughts in about ribosomes. Venki and many other great communicators will be speaking at New Scientist Live, which takes place at ExCeL London between 12 - 14 October 2024, and is also streamed live as well as on-demand.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/09/30/291-venki-ramakrishnan-on-the-biology-of-death-and-aging/

Venkatraman (Venki) Ramakrishnan received his Ph.D. in physics from Ohio University. He is currently Group Leader at the MRC Laboratory of Molecular Biology, Cambridge, England, and is a Fellow of Trinity College. He previously served as President of the Royal Society of London. He shared the Nobel Prize in Chemistry for his work uncovering the structure of the ribosome.

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It's a wonder democracy works at all -- a collection of people with potentially different interests have to agree to abide by majority vote even when it goes against their desires. But as we know, it doesn't always work, and racial and ethnic tensions are one of its biggest challenges. Hahrie Han studies the ground-up workings of democracy, how people can come together to successfully enact change. In her new book Undivided: The Quest for Racial Solidarity in an American Church, she investigates an example where democracy apparently has worked remarkably well, and asks what lessons we can draw from it.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/09/23/290-hahrie-han-on-making-multicultural-democracy-work/

Hahrie Han recieved her Ph.D. in political science from Stanford University. She is currently the Director of the SNF Agora Institute, the Stavros Niarchos Foundation Professor of Political Science, and Faculty Director of the P3 Research Lab at Johns Hopkins University. She was named the Social Innovation Thought Leader of the Year by the World Economic Forum, is a Fellow of the American Academy of Arts and Sciences, and gave the 2024 Tanner Lectures on Human Values at Harvard University, among other awards.

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As an experimental facility, the Large Hadron Collider at CERN in Geneva has been extraordinarily successful, discovering the Higgs boson and measuring multiple features of particle-physics interactions at unprecedented energies. But to theorists, the results have been somewhat frustrating, as we were hoping to find brand-new phenomena beyond the Standard Model. There is nothing to do but to keep looking, recognizing that we have to choose our methods judiciously. I talk with theoretical physicist Cari Cesarotti about what experimental results the modern particle physicist most looks forward to, and how we might eventually get there, especially through the prospect of a muon collider.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/09/16/289-cari-cesarotti-on-the-next-generation-of-particle-experiments/

Cari Cesarotti received her Ph.D. in physics from Harvard University. She is currently a postdoctoral fellow at MIT. Her research is on particle phenomenology theory, with an eye toward experimental searches. Among her awards are the Sakurai Dissertation Award in Theoretical Physics from the American Physical Society and the Young Scientist Award at the 14th International Conference on the Identification of Dark Matter.

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It wasn't that long ago, historically speaking, that you might put on your tuxedo or floor-length evening gown to go out and hear a live opera or symphony. But today's world is faster, more technologically connected, and casual. Is there still a place for classical music in the contemporary environment? Max Richter, whose new album In a Landscape releases soon, proves that there is. We talk about what goes into making modern classical music, how musical styles evolve, and why every note should count.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/09/09/288-max-richter-on-the-meaning-of-classical-music-today/

Max Richter trained in composition and piano at Edinburgh University, at the Royal Academy of Music, and with Luciano Berio in Florence. He was a co-founder of the ensemble Piano Circus. His first solo album, "Memoryhouse," was released in 2002. He has since released numerous solo albums, as well as extensive work on soundtracks for film and television, ballet, opera, and collaborations with visual artists.

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Welcome to the September 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2024/09/02/ama-september-2024/

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One common feature of complex systems is sensitive dependence on initial conditions: a small change in how systems begin evolving can lead to large differences in their later behavior. In the social sphere, this is a way of saying that history matters. But it can be hard to quantify how much certain specific historical events have affected contemporary conditions, because the number of variables is so large and their impacts are so interdependent. Political economist Jean-Paul Faguet and collaborators have examined one case where we can closely measure the impact today of events from centuries ago: how Colombian communities are still affected by 16th-century encomienda, a colonial forced-labor institution. We talk about this and other examples of the legacy of history.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/08/26/287-jean-paul-faguet-on-institutions-and-the-legacy-of-history/

Jean-Paul Faguet received a Ph.D. in Political Economy and an M.Sc. in Economics from the London School of Economics, and an Master of Public Policy from the Kennedy School of Government at Harvard. He is currently Professor of the Political Economy of Development at LSE. He serves as the Chair of the Decentralization Task Force for the Initiative for Policy Dialogue. Among his awards are the W.J.M. Mackenzie Prize for best political science book.

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Understanding how life began on Earth involves questions of chemistry, geology, planetary science, physics, and more. But the question of how random processes lead to organized, self-replicating, information-bearing systems is a more general one. That question can be addressed in an idealized world of computer code, initialized with random sequences and left to run. Starting with many such random systems, and allowing them to mutate and interact, will we end up with "lifelike," self-replicating programs? A new paper by Blaise Agüera y Arcas and collaborators suggests that the answer is yes. This raises interesting questions about whether computation is an attractor in the space of relevant dynamical processes, with implications for the origin and ubiquity of life.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/08/19/286-blaise-aguera-y-arcas-on-the-emergence-of-replication-and-computation/

Blaise Agüera y Arcas received a B.A. in physics from Princeton University. He is currently a vice-president of engineering at Google, leader of the Cerebra team, and a member of the Paradigms of Intelligence team. He is the author of the books Ubi Sunt and Who Are We Now?, and the upcoming What Is Intelligence?

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Being rational necessarily involves engagement with probability. Given two possible courses of action, it can be rational to prefer the one that could possibly result in a worse outcome, if there's also a substantial probability for an even better outcome. But one's attitude toward risk -- averse, tolerant, or even seeking -- also matters. Do we work to avoid the worse possible outcome, even if there is potential for enormous reward? Nate Silver has long thought about probability and prediction, from sports to politics to professional poker. In his his new book On The Edge: The Art of Risking Everything, Silver examines a set of traits characterizing people who welcome risks.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/08/12/285-nate-silver-on-prediction-risk-and-rationality/

Nate Silver received a B.A. in economics from the University of Chicago. He worked as a baseball analyst, developing the PECOTA statistical system (Player Empirical Comparison and Optimization Test Algorithm). He later founded the FiveThirtyEight political polling analysis site. His first book, The Signal and the Noise, was awarded the Phi Beta Kappa Society Book Award in Science. He is the co-host (with Maria Konnikova) of the Risky Business podcast.

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Welcome to the August 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/08/05/ama-august-2024/

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The human brain does a pretty amazing job of taking in a huge amount of data from multiple sensory modalities -- vision, hearing, smell, etc. -- and constructing a coherent picture of the world, constantly being updated in real time. (Although perhaps in discrete moments, rather than continuously, as we learn in this podcast...) We're a long way from completely understanding how that works, but amazing progress has been made in identifying specific parts of the brain with specific functions in this process. Today we talk to leading neuroscientist Doris Tsao about the specific workings of vision, from how we recognize faces to how we construct a model of the world around us.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/07/29/284-doris-tsao-on-how-the-brain-turns-vision-into-the-world/

Doris Tsao received her Ph.D. in neurobiology from Harvard University. She is currently a professor of molecular and cell biology, and a member of the Helen Wills Neuroscience Institute, at the University of California, Berkeley. Among her awards are a MacArthur Fellowship, membership in the National Academy of Sciences, the Eppendorf and Science International Prize in Neurobiology, the National Institutes of Health Director?s Pioneer Award, the Golden Brain Award from the Minerva Foundation, the Perl-UNC Neuroscience Prize, and the Kavli Prize in Neuroscience.

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Change is scary. But sometimes it can all work out for the best. There's no guarantee of that, however, even when the change in question involves the introduction of a powerful new technology. Today's guest, Daron Acemoglu, is a political economist who has long thought about the relationship between economics and political institutions. In his most recent book (with Simon Johnson), Power and Progress: Our Thousand-Year Struggle Over Technology and Prosperity, he looks at how technological innovations affect the economic lives of ordinary people. We talk about how such effects are often for the worse, at least to start out, until better institutions are able to eventually spread the benefits more broadly.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/07/22/283-daron-acemoglu-on-technology-inequality-and-power/

Daron Acemoglu received a Ph.D. in economics from the London School of Economics. He is currently Institute Professor at the Massachusetts Institute of Technology. He is a fellow of the National Academy of Sciences, the American Academy of Arts and Sciences, and the Econometric Society. Among his awards are the John Bates Clark Medal and the Nemmers Prize in Economics. In 2015, he was named the most cited economist of the past 10 years.

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The philosophy of mathematics would be so much easier if it weren't for infinity. The concept seems natural, but taking it seriously opens the door to counterintuitive results. As mathematician and philosopher Joel David Hamkins says in this conversation, when we say that the natural numbers are "0, 1, 2, 3, and so on," that "and so on" is hopelessly vague. We talk about different ways to think about the puzzles of infinity, how they might be resolved, and implications for mathematical realism.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/07/15/282-joel-david-hamkins-on-puzzles-of-reality-and-infinity/

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Joel David Hamkins received his Ph.D. in mathematics from the University of California, Berkeley. He is currently the John Cardinal O'Hara Professor of Logic at the University of Notre Dame. He is a pioneer of the idea of the set theory multiverse. He is the top-rated user by reputation score on MathOverflow. He is currently working on The Book of Infinity, to be published by MIT Press.

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Welcome to the July 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with questions and transcript: https://www.preposterousuniverse.com/podcast/2024/07/08/ama-july-2024/

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Just like with physics, in biology it is perfectly possible to do most respectable work without thinking much about philosophy, but there are unmistakably foundational questions where philosophy becomes crucial. When do we say that a collection of matter (or bits) is alive? When does it become an agent, capable of making decisions? What are the origins of morality and altruistic behavior? We talk with one of the world's leading experts, Samir Okasha, about the biggest issues in modern philosophy of biology.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/07/01/281-samir-okasha-on-the-philosophy-of-agency-and-evolution/

Samir Okasha received his D.Phil. in Philosophy from the University of Oxford. He is currently Professor of the Philosophy of Science at the University of Bristol. He is a winner of the Lakatos Award for his book Evolution and the Levels of Selection, and is a Fellow of the British Academy.

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Which is more intelligent, ChatGPT or a 3-year old? Of course this depends on what we mean by "intelligence." A modern LLM is certainly able to answer all sorts of questions that require knowledge far past the capacity of a 3-year old, and even to perform synthetic tasks that seem remarkable to many human grown-ups. But is that really intelligence? François Chollet argues that it is not, and that LLMs are not ever going to be truly "intelligent" in the usual sense -- although other approaches to AI might get there.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/06/24/280-francois-chollet-on-deep-learning-and-the-meaning-of-intelligence/

François Chollet received his Diplôme d'Ingénieur from École Nationale Supérieure de Techniques Avancées, Paris. He is currently a Senior Staff Engineer at Google. He has been awarded the Global Swiss AI award for breakthroughs in artificial intelligence. He is the author of Deep Learning with Python, and developer of the Keras software library for neural networks. He is the creator of the ARC (Abstraction and Reasoning Corpus) Challenge.

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For those of us who are not dualists, the mind arises from our physical bodies -- mostly the brain, but the rest of the body has a role to play. And yet it remains tempting to treat the mind as a thing in itself, disconnected from how the body is doing. Ellen Langer is a psychologist who is one of the foremost researchers on the idea of mindfulness -- the cognitive skill of paying to one's thoughts, as well as to one's external environment. Her most recent book is The Mindful Body: Thinking Our Way to Chronic Health. We talk about how our state of mind can effect the functions of our body, sometimes in surprising ways.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/06/17/279-ellen-langer-on-mindfulness-and-the-body/

Ellen Langer received her Ph.D. in Social and Clinical Psychology from Yale University. She is currently a professor of psychology at Harvard University. She is also an artist with multiple gallery exhibitions. Among her awards are a Guggenheim Fellowship and the Liberty Science Center Genius Award.

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We claim to love all of our children, friends, and students equally. But perhaps deep down you assign a ranking to them, from favorite to not-so-favorite. Ranking and quantifying people is an irresistible human tendency, and modern technology has made it ubiquitous. In this episode I talk with sociologist Kieran Healy, who has co-authored (with Marion Fourcade) the new book The Ordinal Society, about how our lives are measured and processed by the technological ecosystem around us. We discuss how this has changed how relate to ourselves and the wider world.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/06/10/278-kieran-healy-on-the-technology-of-ranking-people/

Kieran Healy received his Ph.D. in sociology from Princeton University. He is currently a professor of sociology at Duke University, and a member of the Kenan Institute for Ethics. As an undergraduate at University College Cork he won the Irish Times National Debating competition. He has a longstanding interest in data visualization.

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Welcome to the June 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

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Blog post with show notes, questions, and transcript: https://www.preposterousuniverse.com/podcast/2024/06/03/ama-jun-2024/

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String theory, the current leading candidate for a theory of quantum gravity as well as other particles and forces, doesn't connect directly to the world we see. It's possible that there is a large landscape of possible states of theory, with the hope that one of them represents our universe. The existence of a landscape implies the existence of a corresponding swampland -- universes that are not compatible with string theory. I talk with Cumrun Vafa, a respected physicist and originator of the swampland program, about how we might use constraints on what kinds of physics are compatible with string theory to make predictions about cosmology and other experimental regimes.

In the conversation we refer to a famous diagram representing different ten-dimensional string theories, as well as 11-dimensional M-theory, as different limits of an underlying fundamental theory.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/05/27/277-cumrun-vafa-on-the-universe-according-to-string-theory/

Cumrun Vafa received his Ph.D. in physics from Princeton University. He is currently Hollis Professor of Mathematicks and Natural Philosophy, and Chair of the Physics Department, at Harvard University. He has done fundamental work on the dynamics of superstrings, the entropy of black holes, F-theory, and other topics. Among his awards are the Breakthrough Prize in Fundamental Physics, the Dirac Medal, and the Dannie Heineman Prize for Mathematical Physics. He is a member of the American Academy of Arts and Sciences and the National Academy of Sciences. He is the author of the book Puzzles to Unravel the Universe.

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The Earth's climate keeps changing, largely due to the effects of human activity, and we haven't been doing enough to slow things down. Indeed, over the past year, global temperatures have been higher than ever, and higher than most climate models have predicted. Many of you have probably seen plots like this. Today's guest, Gavin Schmidt, has been a leader in measuring the variations in Earth's climate, modeling its likely future trajectory, and working to get the word out. We talk about the current state of the art, and what to expect for the future.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/05/20/276-gavin-schmidt-on-measuring-predicting-and-protecting-our-climate/

Gavin Schmidt received his Ph.D. in applied mathematics from University College London. He is currently Director of NASA's Goddard Institute for Space Studies, and an affiliate of the Center for Climate Systems Research at Columbia University. His research involves both measuring and modeling climate variability. Among his awards are the inaugural Climate Communications Prize of the American Geophysical Union. He is a cofounder of the RealClimate blog.

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Publication week! Say hello to Quanta and Fields, the second volume of the planned three-volume series The Biggest Ideas in the Universe. This volume covers quantum physics generally, but focuses especially on the wonders of quantum field theory. To celebrate, this solo podcast talks about some of the big ideas that make QFT so compelling: how quantized fields produce particles, how gauge symmetries lead to forces of nature, and how those forces can manifest in different phases, including Higgs and confinement.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/05/13/275-solo-quantum-fields-particles-forces-and-symmetries/

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Welcome to the May 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with questions and transcript: https://www.preposterousuniverse.com/podcast/2024/05/06/ama-may-2024/

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Here is the memorial to Dan Dennett at Ars Technica.

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Modern biology is advancing by leaps and bounds, not only in understanding how organisms work, but in learning how to modify them in interesting ways. One exciting frontier is the study of tiny "robots" created from living molecules and cells, rather than metal and plastic. Gizem Gumuskaya, who works with previous guest Michael Levin, has created anthrobots, a new kind of structure made from living human cells. We talk about how that works, what they can do, and what future developments might bring.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/04/29/274-gizem-gumuskaya-on-building-robots-from-human-cells/

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Gizem Gumuskaya received her Ph.D. from Tufts University and the Harvard Wyss Institute for Biologically-Inspired Engineering. She is currently a postdoctoral researcher at Tufts University. She previously received a dual master's degree in Architecture and Synthetic Biology from MIT.

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