Moderna's Covid-19 vaccine would not have scaled without Ginkgo Bioworks. Reshma Shetty, co-founder and COO of Ginkgo ? slated to go public via SPAC acquisition at a reported $15 billion valuation ? explains how biotech innovation can build a better future now. Ginkgo's platform already serves industries from food and agriculture, to materials, to healthcare. Shetty acknowledges that engineering genes is a high stakes pursuit, and says Ginkgo is trying to pair the ambition of Silicon Valley with a "higher level of care" than consumer tech companies like social media have demonstrated. The key, Shetty says, is creating an unstable equilibrium ? propelling progress but not at the expense of principles.

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You can make your social impact and your bottom line work hand-in-hand. But you'll have to be as creative and innovative about your company's values as you are about the business itself. Howard Schultz, chair and former CEO of Starbucks, not only changed how America wakes up, but set new standards for employee benefits. From offering college tuition to American employees to providing health care for employees' parents in China, Howard has always been one step ahead of the social impact curve.

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As a new leader, how do you honor an established brand while trying to shepherd it into the next era? Las Vegas Raiders? president Sandra Douglass Morgan took the helm amid a front office scandal and a team new to the desert. Morgan talks about prioritizing customers over all else, taking risks at the beginning of a new venture, and why to bet on yourself from the moment you apply for a job. 

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Innovation is the lifeblood of the start-up ? from product to processes and culture to creativity. But innovation is just as essential for scale companies. So how do you keep the innovation flywheel spinning at all levels of scale? The answer according to Linda Yates is to seed every level of your company with an intrapreneurial mindset. As CEO of Mach49, an incubator for large global companies, Linda shares her vast experience and strategies for injecting intrapreneurial thinking and bias-to-action across hundreds of large-scale organizations.

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Hybrid, remote, in-person, a little bit of everything? Work has transformed into a giant experiment. Priya Parker, expert facilitator and author of The Art of Gathering: How We Meet and Why It Matters, shares her advice on how to manage the new hybrid workplace. Where to start? Focus first, she suggests, on making your meetings better.

Read a transcript of this interview: https://mastersofscale.com/mastering-the-hybrid-workplace-priya-parker/

Get a free copy of Priya Parker's guide to hybrid gatherings: https://www.priyaparker.com/the-hybrid-gathering-guide

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Taking risks can be the catalyst for immense scale or dire straits. Avoiding taking any risks at all leads to stagnancy and empowered competitors. The key is to know which risks are worth taking, and when and how to take them. This episode highlights the best conversations we?ve had recently about taking advantage of risk and how fortune favors the brave. 

Featuring New Georgia Project?s Stacey Abrams, Care.com?s Sheila Lirio Marcelo, Bankable Productions & SMiZE Cream?s Tyra Banks, MetricStream?s Shellye Archambeau, Moderna?s Stéphane Bancel, Digital Undivided?s Kathryn Finney, Ellevest?s Sallie Krawcheck, and American Express?s Ken Chenault. 

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After slashing his NYC restaurant team from 2,400 people to just 45 in the teeth of the pandemic, Danny Meyer has rebuilt Union Square Hospitality Group back to its former size. But in his fifth appearance on Rapid Response since Covid struck, Danny says he isn?t yet triumphant. With inflation creating fresh challenges even at Shake Shack, Danny shares lessons on the good and bad of leading through a crisis, plus explains why he?s handed off his CEO title ? and where he finds inspiration to fuel new innovations.

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For truly sustainable long-term growth, you must prioritize your mission over your product ? even if that means letting your product go. Noom founder and CEO Saeju Jeong has repeatedly turned his back on successful products in the name of his mission to help as many people as possible live healthier lives. In this episode, Saeju brings to life many of these make-or-break moments, and how his dedication to mission has driven his scale journey.

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When markets are in turmoil, you can?t rely on business as usual, but that doesn?t mean you should panic. As the housing climate has turned volatile, rest estate marketplace Zillow has been forced to rethink some priorities, while doubling down on others. Zillow president Susan Daimler talks about the importance of a strategy focused on the future, despite layoffs and pullbacks, and how maintaining a clear shared mindset has enabled forward progress in a challenging climate. 

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Can a small entrepreneur make an impact within a massive, complex system, like healthcare or education? What's the best framework to amplify the positive side of having co-founders and avoid the negatives? Reid Hoffman and Bob Safian answer these and more questions from small business owners in the Masters of Scale community. Plus: in our Need to Know segment, Reid & Bob take on a burning question: How can Black founders beat the odds and find funding?

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Partnerships can be the secret weapon to rocketing your company to the next level. That?s what Cathy Zoi discovered when she became the CEO of charging station network, EVgo. Whether it be partnering with grocery and department stores, or aligning with the Tesla customer-base, targeting allies and collaborators are a crucial catalyst for how EVgo has grown to become the nation?s largest public EV charging network. 

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To achieve massive scale, you don?t just need founders, you also need a re-founder ? someone to come in at a later stage to keep the mission and culture on track. As Microsoft?s third CEO ever ? after Bill Gates and Steve Ballmer ? Satya Nadella is doing just that. He?s fostered a culture at Microsoft that rewards new ideas and makes room for feedback. Satya discusses how, as Chairman and CEO, he has transformed Microsoft from a cutthroat culture towards embracing social networks, collaboration, and cloud. Plus, Satya and Reid reminisce about the early conversations that led to Microsoft?s acquisition of LinkedIn. With guest David Mandel, showrunner of Veep.

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Too many businesses and organizations spend time planning and not enough in action, especially in times of emergency. José Andrés, world-famous chef and founder of the nonprofit World Central Kitchen, proves the value of fast action through his work, including his recent time in Ukraine serving over 150 million meals. José thinks businesses should flatten their power structure and treat food as a national security issue, even in places like the U.S.  

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When is it time to double down on your instincts, and when is it time to open yourself up to feedback? Sometimes it comes down to a hard call? that you might get totally wrong. In Part Two of our episode with Patreon?s Jack Conte, you?ll hear how he was able to raise capital by telling his authentic story after a series of pitches that went disastrously wrong! And you?ll hear how his worst mistake as a founder helped him reconnect with Patreon?s mission and community, and build Patreon into a $4B company. How can being wrong accelerate your business? It takes running at the solution with insatiable curiosity. 

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When it comes to racial justice, many companies and organizations haven't matched their reality to their words. Rashad Robinson, the president of Color of Change, the largest online racial justice organization in the U.S., is holding major corporations accountable. Hear Rashad talk through the difficulties of changing systems from Hollywood, Silicon Valley, to Washington DC, getting help from President Barack Obama, and what business leaders can do to actively change racial injustice.

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Building a business means making mistakes. Lots of them. But how you?re wrong isn?t always obvious. Jack Conte has learned this lesson as a working musician ? and while scaling Patreon into a company worth $4b. In Part One of a two-part series, you?ll hear how Jack wrote his own Wrongness Playbook, as he learned to answer questions like: If something isn?t working, is it time to trust your instincts? Or is there critical feedback you?ve been ignoring? 

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Amazon wants to get bigger, but with that scale comes great responsibility. So says Adam Selipsky, CEO of Amazon Web Services, the most profitable and fastest growing part of the tech giant. Selipsky, who also oversees Amazon?s climate change efforts, points to two additions to the company?s vaunted ?Leadership Principles? as evidence of Amazon?s commitment. Arguing that AWS is still in early days, he shares what he?s hearing from other CEOs about their biggest concerns, why ?carbon intensity? is the best measure of climate progress for businesses, and what Amazon's aspiration to be ?Earth?s best employer? really means. 

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How can small businesses survive in times of volatility? How should an entrepreneur balance limited resources with big ambitions? Reid Hoffman and Bob Safian answer questions from small business owners in the Masters of Scale community. Plus: another round of Pivot Point, and a Need to Know segment.

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Eric Schmidt, former CEO of Google, breaks down his deep insights around artificial intelligence on Rapid Response. Schmidt, co-author of the book "The Age of AI: And Our Human Future," alongside Dr. Henry Kissinger and MIT?s Daniel Huttenlocher, says that we?re entering an unknown era with technology ? one that requires extra vigilance to ensure that we amplify the positives and de-amplify the negatives. His advice to businesses: You need to be running as fast as you can toward AI applications. If your competitor gets there first, you'll be in trouble. Schmidt argues that AI will change business, society, and potentially humanity itself. "It's important that our systems not enable the worst of us, but instead promote the best of us,? he says.

Read the book "The Age of AI: And Our Human Future" from Henry Kissinger, Eric Schmidt, and Daniel Huttenlocher: https://www.barnesandnoble.com/w/the-age-of-ai-henry-a-kissinger/1139558876?ean=9780316273800

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Creative energy is the raw fuel of entrepreneurship, but if you fail to direct that energy effectively, you risk chasing multiple ideas and delivering none. Tony Fadell learned this lesson time and again through his journey to co-create the iPod, iPhone, and Nest. He shares how he struck the tricky balance of channeling his creative experimentation into world-changing products.

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The fallout from the pandemic is proving to be as challenging for business leaders to navigate as the pandemic?s onset. Target?s CEO Brian Cornell had to make difficult decisions in the second quarter of this year to manage an unexpected surplus of goods and home technology. He shares his most recent learnings, as well as lessons for handling skepticism, the need for agility, and why mental wellness is key to a successful team. 

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How did Bill Gates scale BOTH a global business and a global philanthropy? He spotted an inflection point in history ? and accelerated it. What does that take? A great idea, great timing, and also: Great partners. Because even Bill Gates doesn?t go it alone. In Part 1 of this special two-part episode, Bill reflects with Reid on the founding and growth of Microsoft ? how he not only spotted an inflection point (hello, personal computers) but accelerated it to massive scale (forget computers, let's talk platforms). There?s timeless wisdom in Bill?s ability to identify inflection points, build strategic partnerships, and just work harder than everyone else. In Part 2, Bill reflects on scaling the Bill & Melinda Gates Foundation, and the different lessons learned between the two.

Listen to Part 2: https://listen.mastersofscale.com/Bill-Gates-Part-2

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?Go for the megatons.? That?s John Doerr?s recommendation for how we need to combat the existential threat of climate change. Doerr, a venture capitalist and author of the new book Speed and Scale, joins host Bob Safian to discuss our decarbonization efforts, what he calls ?the greatest economic opportunity of the next century.? The book quantifies the specific societal needs, in six discrete areas, to achieve a carbon-neutral world. John isn?t arguing that we all need to be vegan ascetics, but rather, the need for collective action ? and the critical role that business plays in advancing that movement. 

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If you?re a leader right now navigating the global pandemic, supply chain disruptions, and your own mental list of what?s keeping you up at night, the issue of burnout is probably on your mind. You can?t shield your team from all stress, but you can find effective ways of supporting your employees through it. This episode highlights the best conversations we?ve had recently about stopping burnout in your organization, before it takes hold. 

Featuring BetterUp?s Alexi Robichaux, Upwork?s Hayden Brown, Merck?s Ken Frazier, Chobani?s Hamdi Ulukaya, director J.J. Abrams, Girls Who Code?s Reshma Saujani, BW4BL?s Tokunbo Koiki, and FuelFinance?s Alyona Mysko.

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Crypto winter isn?t a disaster, it's an opportunity. That?s how Michael Gronager, CEO of $8 billion crypto data company Chainalysis, describes the crashing prices and bankruptcies that have roiled the cryptocurrency sector. Gronager offers an insider?s perspective on operating in a volatile marketplace, providing lessons on dreaming too big in boom times and on leaning into building and creating when lulls emerge. Chainalysis helps track financial flows on blockchains, including crypto criminals from North Korea and Russia. Despite current risks, Gronager argues, the still-emerging crypto sector is maturing, and he?s as confident as ever about its future. 

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Reid Hoffman and Bob Safian sit down to discuss how today?s hot-button stories are impacting business. The co-hosts address the key trends that all entrepreneurs should be up to speed on, from the looming recession and cryptocurrency?s possible demise to the hybrid workplace and moral leadership. Featuring Mercy Corps? Tjada McKenna, PwC?s Tim Ryan, and Girls Who Code?s Reshma Saujani.

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?Hope is a practice. It comes from doing.? As the head of Planned Parenthood, Alexis McGill Johnson is regrouping in the wake of the U.S. Supreme Court?s decision to remove the federal right to safe abortion. Johnson is now faced with the challenge to move her team from tears and shock to action. Any leader faced with a worst-case scenario can learn from her vision: ?to fight and stay courageous, and maintain ourselves.?

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If you want to capitalize on an opportunity that you think could change the world, you need to drive full speed toward it. Back in 1994, when Ajaz Ahmed dropped out of college to start one of the first digital ad agencies, AKQA, he knew he was at the cusp of the next revolution in tech. And if he wanted to be part of it, he?d have to move fast. Ahmed shares stories about how a band of 21-year-old dropouts built the agency from ground up, winning over early clients by building prototypes ahead of the competition. He dives into how his inner voice demanding him to ?get big or die trying? led him to transform AKQA into a global agency with thousands of employees and the biggest clients in the world, like Nike, Virgin, and Usher.

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What?s the difference between an activist brand and an active brand? Impossible Foods CEO Peter McGuinness says that acting on your values defines a business ? from climate change to Roe v. Wade. To unleash the next wave of growth for plant-based meat purveyor Impossible, McGuiness is rethinking how the whole category presents itself, taking aim at what he calls ?safe and lame? approaches, partnering with the likes of Billie Eilish, and targeting the $1.4 trillion global meat industry.

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Every company has its own internal factions: engineers vs. designers, East Coast vs. West, IT vs. everybody. The trick is turning factionalism into healthy competition that propels you toward your shared mission. At Motorola, Cisco, and now her start-up Fable, Padma Warrior has tapped into the power of internal divisions. It's not about separating people into warring camps; it's about building bridges from our differences, rather than divisions.

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Volunteering and service are muscles that can close America?s divides and push social change. Speaking live at the 2022 Social Innovation Summit in Washington, D.C., AmeriCorps? new CEO, Michael Smith, shares a vision for healing sociopolitical divides through partnerships and on-the-ground experiences. When it comes to tackling natural and social crises, he?s prioritizing impact over volume. 

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The true seed of scale is customer love, which you can?t buy, hack, or game. Sam Altman, former president of Y Combinator, scaled countless start-ups by focusing on this one idea: Finding 100 users who love you is better than 1 million who kinda like you. As CEO of OpenAI, Sam leads the creation of genuinely useful AI products. He shares timeless insights in his interview from 2018 on how to build on the love of passionate customers to create world-shifting tools.

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When a tech nonprofit competes against a $2 billion incumbent dominating the market, its odds are slim. But Zo Orchingwa took that bet, founding Ameelio, believing that access to communication and education for the incarcerated is needed for their future success. Ameelio is on a quest to partner with every prison district in the country until one day, it scales enough to be redundant.   

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The first stage of building up a business is to break things down. Michael Dell started a computer company in his dorm room by cracking open some early IBM PCs and figuring out what he could do better, faster, and cheaper. Then he did the same thing to the entire model of computer sales. Learn from Dell how to revolutionize an industry ? using deconstruction to gain insight your competitors lack, and then building something bigger and better.

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While gasoline prices soar, solar company Sunrun is poised to usher in a customer-led revolution of distributed energy technologies. Sunrun?s CEO Mary Powell combats a ?no and slow? culture to transform more homes into virtual energy plants by preaching optimism and scorning bureaucracy. She?s moving with urgency to create a cleaner and more cost-effective future as fast as possible.

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Delivering human dignity to your customers is more than just good practice. It can be a powerful engine of scale. This insight has inspired Phaedra Ellis-Lamkins her whole career, as a labor leader, a music manager, and now as a fin-tech entrepreneur with Promise. Her secret? Take a contrarian lens to existing systems. Find a space where human dignity is lacking, create a product that gives your customers flexibility, options, access they didn?t have before ? and unlock new value.

Watch the signed version of Amber Galloway's story: https://www.youtube.com/watch?v=F24FZz1DczA

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For Reid Hoffman, the way to live a meaningful and productive life is to focus on one key area: friendships. Speaking at Vanderbilt University?s 2022 commencement, he shares four lessons on why friendships are crucial for helping us achieve our potential and enact meaningful change. 

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Most future of work conversations revolve around the ?where,? but Upwork CEO Hayden Brown says it?s more important to focus on the ?who.? 10% of the workforce at Upwork, the global tech platform for millions of freelance workers, was directly impacted by the Ukrainian war. Hayden?s people-focused approach to the difficult decision of how to manage remote employees in Russia is the same mindset she applies to meet the needs of all workers, from people feeling conflict to working mothers.

Learn more about scaling your hybrid workforce with highly skilled talent: www.upwork.com/masters-of-scale

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How can a small business survive a David vs. Goliath competition? If two sets of stakeholders have opposing needs, how can a startup pivot to keep them both happy? Reid Hoffman and Bob Safian answer these questions and more from small business owners in the Masters of Scale community. Plus: another round of Pivot Point!

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Entrepreneurship is an essential tool for building a more equitable society ? which is why Kathryn Finney is laser-focused on encouraging people who don?t fit the mold of the stereotypical founder to jump in. Her new book, ?Build the Damn Thing,? taps into wisdom from her years at the venture studio Genius Guild and beyond. She brings a message to founders: The universe is conspiring for your greatness. 

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In just 6 years, Facebook grew to 2 billion users and 14,000 employees. How? Well, first, they hired COO Sheryl Sandberg. And she knew that to lead a fast-changing organization, you have to be as skilled at breaking plans as you are at making them. Great scale leaders know how to pivot, because every day there are new competitors, new threats, new opportunities. Sandberg shares the practical, tactical on-the-ground leadership lessons she learned while scaling at Google and Meta.

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"Corporations can be a force for good ? and they can also be very successful," says Ken Chenault, chair of investment firm General Catalyst and former longtime CEO of American Express. During the past year, Ken has been an outspoken advocate for business leaders to actively engage in societal matters. After George Floyd?s death, he and Merck CEO Ken Frazier launched OneTen, a coalition to create 1 million jobs for Black Americans that now includes major brands from IBM to Nike to Walmart. Chenault has pushed corporate chiefs to use their leverage to protect voting rights, and he's come out with a platform for Responsible Innovation that puts what he calls ?social due diligence? alongside financial due diligence. Standing up for what's right, Ken says, fuels long-term success: "The most important thing is the quest for truth, character, and values."

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A diverse network of collaborators is key when making scale leaps. Moderna CEO Stéphane Bancel has cultivated a wide network of scientists, business leaders, and government officials across his career. When COVID-19 struck, Bancel called upon this nexus of experts to aid the warp-speed development of the mRNA-based vaccine in the race to save millions of lives.

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It?s easy to have a grand idea; putting that plan into action is not. Victoria Yampolsky conceived of a global concert in support of Ukraine. Without any experience in entertainment or international aid, she shares how she didn?t accept ?no? for an answer in her quest to book big-name guests like Pink Floyd and negotiate a streaming deal ? to pursue a fundraising goal of $10 million.

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If you're launching a moonshot, success depends on how you manage the trajectory of risk. When Stéphane Bancel became Moderna's first CEO, the biotech start-up was chasing a way-out idea many experts thought was impossible. Stéphane built a culture of calculated risk-taking to create a platform for extraordinary leaps ? one that enabled life-saving mRNA vaccines when Covid-19 struck.

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With the workplace in historic flux, consulting firm PwC is committing a whopping $2.4 billion to create an employee engagement platform offering a radically new level of choice. PwC?s U.S. chair, Tim Ryan, shares why the bold initiative is necessary in the face of the Great Resignation. It's just one of several evolving crises, Ryan says, that has made leading a business more complex and demanding than ever.

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Massive change isn?t something you can brute-force ? you need to ignite buy-in, again and again, up and down your organization. Because even if your changes will make things more fun, more interesting, and more profitable, you?re going to face defiance and inertia until you clue everyone in. That?s what Bill Ford learned while working to remake Ford Motor Company as an environmental powerhouse ? against surprising internal and even national-level resistance. 

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Has Gopuff cracked the code of instant delivery ? a field where even Amazon has struggled? Co-founder Yakir Gola talks about the challenge of owning the customer journey from app to warehouse to doorstep, and the reasons why being outside Silicon Valley is giving Gopuff a big advantage as it expands across the United States and around the world. Yakir talks with host Bob Safian about why moving fast is only one piece of the growth puzzle.

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We often hear the story about the great leader who joins a legacy company and guides it through massive transformation. But massive transformation can also start from the inside. Bill Ford, the executive chair of the Ford Motor Company, founded by his great-grandfather, is proof that great change can come from within. He has led not just one but multiple refreshes of Ford?s mission, culture, and, especially, their approach to sustainability. In Part One of a two-part series, you?ll hear about Bill Ford?s unusual entry into the family business and how he learned to drive change against internal resistance.

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Charity Dean was one of the first public health officials to set the alarm on COVID. When she searched for a tool to forecast future bio threats, she realized that it didn?t exist yet. So she co-founded the Public Health Company, where she uses lessons from her government experiences, but without the same rules or limits. She speaks with Bob Safian about why all companies must be public health companies.

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